日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

CRISPR-Cas9 Screening Identifies Resistance Mechanisms to KRAS Inhibition in Pancreatic Cancer

CRISPR-Cas9筛选揭示胰腺癌中KRAS抑制的耐药机制

Long, Szu-Aun; Todd, Haley; Goodhart, Grace; Chang, Wen-Hsuan; Amparo, Amber M; Bridgens, Rachel; Dilly, Julien; Park, Se Jun; Beal, Robert M; Shehadeh, Sara M; Satyadi, Megan A; Trivedi, Vidushi K; Ackermann, Sarah E; Mukherjee, Raivath; Goodwin, Craig M; Edwards, A Cole; Stalnecker, Clint A; Greis, Kenneth D; Aguirre, Andrew J; Hobbs, G Aaron; Bryant, Kirsten L; Ahmad, Syed A; Cox, Adrienne D; Der, Channing J; Waters, Andrew M

Combination of the MTA-Cooperative PRMT5 Inhibitor BMS-986504 and KRAS Inhibitors Is an Effective Treatment Strategy for MTAP-Deleted KRAS-Mutant Pancreatic Cancer

MTA 协同 PRMT5 抑制剂 BMS-986504 与 KRAS 抑制剂联合使用是治疗 MTAP 缺失 KRAS 突变型胰腺癌的有效策略

Drizyte-Miller, Kristina; Engstrom, Lars D; Klomp, Jeffrey A; Stalnecker, Clint A; Stamey, Addison G; Taylor, Khalilah E; Roach, Mallory K; Robb, Ryan; Waters, Laura M; Calinisan, Andrew; Degan, Seamus; Chang, Wen-Hsuan; Helu, Xousaen M; Nguyen, David; Baldelli, Elisa; Pierobon, Mariaelena; Petricoin, Emanuel F; Briere, David M; Hallin, Jill; Christensen, James G; Bryant, Kirsten L; Cox, Adrienne D; Olson, Peter; Der, Channing J

Concurrent Inhibition of the RAS-MAPK Pathway and PIKfyve Is a Therapeutic Strategy for Pancreatic Cancer.

同时抑制 RAS-MAPK 通路和 PIKfyve 是胰腺癌的一种治疗策略

DeLiberty Jonathan M, Roach Mallory K, Stalnecker Clint A, Robb Ryan, Schechter Elyse G, Pieper Noah L, Taylor Khalilah E, Pita Lily M, Yang Runying, Bang Scott, Drizyte-Miller Kristina, Ackermann Sarah E, Nicewarner Peña Sheila R, Baldelli Elisa, Min Sophia M, Drewry David H, Petricoin Emanuel F 3rd, Morris John P 4th, Der Channing J, Cox Adrienne D, Bryant Kirsten L

KRAS: the Achilles' heel of pancreas cancer biology

KRAS:胰腺癌生物学的阿喀琉斯之踵

Drizyte-Miller, Kristina; Talabi, Taiwo; Somasundaram, Ashwin; Cox, Adrienne D; Der, Channing J

"Undruggable KRAS": druggable after all

“不可药物治疗的KRAS”:终究还是可以药物治疗的

Cox, Adrienne D; Der, Channing J

Dordaviprone/ONC201 Activation of the ClpP Mitochondrial Protease Inhibits the Growth of KRAS-Mutant Pancreatic Cancer and Overcomes RAS Inhibitor Resistance

多达维普隆/ONC201激活ClpP线粒体蛋白酶,抑制KRAS突变型胰腺癌的生长并克服RAS抑制剂耐药性。

Drizyte-Miller, Kristina; Degan, Seamus E; Mouery, Ryan D; Amparo, Amber M; Mouery, Brandon L; Chang, Wen-Hsuan; Yang, Runying; Nicewarner Peña, Sheila R; Baldelli, Elisa; Klomp, Jeffrey A; Iwanowicz, Edwin J; Graves, Lee M; Petricoin, Emanuel F; Cox, Adrienne D; Stalnecker, Clint A; Bryant, Kirsten L; Der, Channing J

Concurrent Inhibition of ERK and Farnesyltransferase Suppresses the Growth of HRAS Mutant Head and Neck Squamous Cell Carcinoma

同时抑制ERK和法尼基转移酶可抑制HRAS突变型头颈部鳞状细胞癌的生长

Javaid, Sehrish; Schaefer, Antje; Goodwin, Craig M; Nguyen, Victoria V; Massey, Frances L; Pierobon, Mariaelena; Gambrell-Sanders, Da'Jhnae; Waters, Andrew M; Lambert, Kathryn N; Diehl, J Nathaniel; Hobbs, G Aaron; Wood, Kris C; Petricoin, Emanuel F; Der, Channing J; Cox, Adrienne D

Filling in the GAPs in understanding RAS

填补对 RAS 理解的空白

Cox, Adrienne D; Der, Channing J

Engineering threshold-based selection systems

基于阈值的工程选择系统

Pedone, Katherine H; González-Pérez, Vanessa; Leopold, Luciana E; Rasmussen, Neal R; Der, Channing J; Cox, Adrienne D; Ahmed, Shawn; Reiner, David J

Gain-of-Function RHOA Mutations Promote Focal Adhesion Kinase Activation and Dependency in Diffuse Gastric Cancer

RHOA 功能获得性突变促进弥漫性胃癌中黏着斑激酶的激活和依赖性

Zhang, Haisheng; Schaefer, Antje; Wang, Yichen; Hodge, Richard G; Blake, Devon R; Diehl, J Nathaniel; Papageorge, Alex G; Stachler, Matthew D; Liao, Jennifer; Zhou, Jin; Wu, Zhong; Akarca, Fahire G; de Klerk, Leonie K; Derks, Sarah; Pierobon, Mariaelena; Hoadley, Katherine A; Wang, Timothy C; Church, George; Wong, Kwok-Kin; Petricoin, Emanuel F; Cox, Adrienne D; Lowy, Douglas R; Der, Channing J; Bass, Adam J