日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Serum factors create species-specific barriers to hepatic gene transfer by lipid nanoparticles in liver-humanized mice.

在肝脏人源化小鼠中,血清因子对脂质纳米颗粒介导的肝脏基因转移形成物种特异性屏障

Stone Daniel, Takeuchi Ryo, Dulin Harrison, Loprieno Michelle A, Strongin Daniel E, Sathees Saraswathi, Cradick Thomas J, Aubert Martine, Roychoudhury Pavitra, Gordon Jennifer, Jerome Keith R

Correction: Preclinical safety and biodistribution of CRISPR targeting SIV in non-human primates

更正:CRISPR靶向SIV在非人灵长类动物中的临床前安全性和生物分布

Burdo, Tricia H; Chen, Chen; Kaminski, Rafal; Sariyer, Ilker K; Mancuso, Pietro; Donadoni, Martina; Smith, Mandy D; Sariyer, Rahsan; Caocci, Maurizio; Liao, Shuren; Liu, Hong; Huo, Wenwen; Zhao, Huaqing; Misamore, John; Lewis, Mark G; Simonyan, Vahan; Thompson, Elaine E; Xu, Ethan Y; Cradick, Thomas J; Gordon, Jennifer; Khalili, Kamel

Strategic self-limiting production of infectious HIV particles by CRISPR in permissive cells

在受控细胞中通过 CRISPR 策略性地自我限制产生传染性 HIV 颗粒

Hong Liu, Chen Chen, Shuren Liao, Danielle K Sohaii, Conrad R Y Cruz, Tricia H Burdo, Thomas J Cradick, Anand Mehta, Carlos Barrero, Magda Florez, Jennifer Gordon, Stephane Grauzam, James Dressman, Shohreh Amini, Catherine M Bollard, Rafal Kaminski, Kamel Khalili

In vivo genome editing at the albumin locus to treat methylmalonic acidemia

在白蛋白基因座进行体内基因组编辑以治疗甲基丙二酸血症

Jessica L Schneller, Ciaran M Lee, Leah E Venturoni, Randy J Chandler, Ang Li, Sangho Myung, Thomas J Cradick, Ayrea E Hurley, William R Lagor, Gang Bao, Charles P Venditti

Evaluation of Homology-Independent CRISPR-Cas9 Off-Target Assessment Methods

同源性独立的 CRISPR-Cas9 脱靶评估方法的评估

Hemangi G Chaudhari, Jon Penterman, Holly J Whitton, Sarah J Spencer, Nicole Flanagan, Maria C Lei Zhang, Elaine Huang, Aditya S Khedkar, J Mike Toomey, Courtney A Shearer, Alexander W Needham, Tony W Ho, John D Kulman, T J Cradick, Andrew Kernytsky

Streptococcus thermophilus CRISPR-Cas9 Systems Enable Specific Editing of the Human Genome

嗜热链球菌 CRISPR-Cas9 系统可实现对人类基因组的特异性编辑

Müller, Maximilian; Lee, Ciaran M; Gasiunas, Giedrius; Davis, Timothy H; Cradick, Thomas J; Siksnys, Virginijus; Bao, Gang; Cathomen, Toni; Mussolino, Claudio

A Burden of Rare Variants Associated with Extremes of Gene Expression in Human Peripheral Blood

人类外周血中与基因表达极端相关的罕见变异负担

Zhao, Jing; Akinsanmi, Idowu; Arafat, Dalia; Cradick, T J; Lee, Ciaran M; Banskota, Samridhi; Marigorta, Urko M; Bao, Gang; Gibson, Greg

TALENs Facilitate Single-step Seamless SDF Correction of F508del CFTR in Airway Epithelial Submucosal Gland Cell-derived CF-iPSCs

TALENs促进气道上皮黏膜下腺细胞来源的CF-iPSCs中F508del CFTR的单步无缝SDF校正

Suzuki, Shingo; Sargent, R Geoffrey; Illek, Beate; Fischer, Horst; Esmaeili-Shandiz, Alaleh; Yezzi, Michael J; Lee, Albert; Yang, Yanu; Kim, Soya; Renz, Peter; Qi, Zhongxia; Yu, Jingwei; Muench, Marcus O; Beyer, Ashley I; Guimarães, Alessander O; Ye, Lin; Chang, Judy; Fine, Eli J; Cradick, Thomas J; Bao, Gang; Rahdar, Meghdad; Porteus, Matthew H; Shuto, Tsuyoshi; Kai, Hirofumi; Kan, Yuet W; Gruenert, Dieter C

Efficient fdCas9 Synthetic Endonuclease with Improved Specificity for Precise Genome Engineering

高效合成的fdCas9核酸内切酶,具有更高的特异性,可用于精确的基因组工程

Aouida, Mustapha; Eid, Ayman; Ali, Zahir; Cradick, Thomas; Lee, Ciaran; Deshmukh, Harshavardhan; Atef, Ahmed; AbuSamra, Dina; Gadhoum, Samah Zeineb; Merzaban, Jasmeen; Bao, Gang; Mahfouz, Magdy

TALENs facilitate targeted genome editing in human cells with high specificity and low cytotoxicity

TALEN 有利于在人类细胞中进行靶向基因组编辑,具有高特异性和低细胞毒性

Claudio Mussolino, Jamal Alzubi, Eli J Fine, Robert Morbitzer, Thomas J Cradick, Thomas Lahaye, Gang Bao, Toni Cathomen