日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

EGFR targeting PhosTACs as a dual inhibitory approach reveals differential downstream signaling

EGFR 靶向 PhosTAC 作为双重抑制方法揭示了差异下游信号

Zhenyi Hu, Po-Han Chen, Wenxue Li, Mackenzie Krone, Sijin Zheng, Jacques Saarbach, Ines Urquizo Velasco, John Hines, Yansheng Liu, Craig M Crews

Hijacking Methyl Reader Proteins for Nuclear-Specific Protein Degradation

劫持甲基读取蛋白进行核特异性蛋白降解

Dhanusha A Nalawansha ,Ke Li ,John Hines ,Craig M Crews

Mutant-selective degradation by BRAF-targeting PROTACs

BRAF 靶向 PROTAC 进行突变体选择性降解

Shanique Alabi, Saul Jaime-Figueroa, Zhan Yao, Yijun Gao, John Hines, Kusal T G Samarasinghe, Lea Vogt, Neal Rosen, Craig M Crews

BET proteolysis targeted chimera-based therapy of novel models of Richter Transformation-diffuse large B-cell lymphoma

针对 Richter 转化型弥漫大 B 细胞淋巴瘤新型模型的 BET 蛋白水解靶向嵌合体治疗

Warren Fiskus #, Christopher P Mill #, Dimuthu Perera, Christine Birdwell, Qing Deng, Haopeng Yang, Bernardo H Lara, Nitin Jain, Jan Burger, Alessandra Ferrajoli, John A Davis, Dyana T Saenz, Wendy Jin, Cristian Coarfa, Craig M Crews, Michael R Green, Joseph D Khoury, Kapil N Bhalla

Targeted degradation of transcription factors by TRAFTACs: TRAnscription Factor TArgeting Chimeras

TRAFTACs靶向降解转录因子:转录因子靶向嵌合体

Kusal T G Samarasinghe ,Saul Jaime-Figueroa ,Michael Burgess ,Dhanusha A Nalawansha ,Katherine Dai ,Zhenyi Hu ,Adrian Bebenek ,Scott A Holley ,Craig M Crews

Modulation of Phosphoprotein Activity by Phosphorylation Targeting Chimeras (PhosTACs)

磷酸化靶向嵌合体 (PhosTAC) 对磷蛋白活性的调节

Po-Han Chen, Zhenyi Hu, Elvira An, Ifunanya Okeke, Sijin Zheng, Xuanmeng Luo, Angela Gong, Saul Jaime-Figueroa, Craig M Crews

Targeted Degradation of Oncogenic KRASG12C by VHL-Recruiting PROTACs

VHL 募集 PROTAC 靶向降解致癌基因 KRASG12C

Michael J Bond, Ling Chu, Dhanusha A Nalawansha, Ke Li, Craig M Crews

Multiplex CRISPR/Cas screen in regenerating haploid limbs of chimeric Axolotls

嵌合蝾螈单倍体肢体再生中的多重 CRISPR/Cas 筛选

Lucas D Sanor #, Grant Parker Flowers #, Craig M Crews

Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties

蛋白水解靶向嵌合体 (PROTAC) 的设计、合成和生物学评估,作为具有改进药代动力学特性的 BTK 降解剂

Saul Jaime-Figueroa, Alexandru D Buhimschi, Momar Toure, John Hines, Craig M Crews

Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase

不同的 PROTAC 底物特异性由募集的 E3 连接酶的方向决定

Blake E Smith, Stephen L Wang, Saul Jaime-Figueroa, Alicia Harbin, Jing Wang, Brian D Hamman, Craig M Crews