日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Combination Therapies with CDK4/6 Inhibitors to Treat KRAS-Mutant Pancreatic Cancer

与 CDK4/6 抑制剂联合治疗 KRAS 突变型胰腺癌

Craig M Goodwin, Andrew M Waters, Jennifer E Klomp, Sehrish Javaid, Kirsten L Bryant, Clint A Stalnecker, Kristina Drizyte-Miller, Bjoern Papke, Runying Yang, Amber M Amparo, Irem Ozkan-Dagliyan, Elisa Baldelli, Valerie Calvert, Mariaelena Pierobon, Jessica A Sorrentino, Andrew P Beelen, Natalie Bub

VCP/p97, a pleiotropic protein regulator of the DNA damage response and proteostasis, is a potential therapeutic target in KRAS-mutant pancreatic cancer

VCP/p97 是一种多效性的 DNA 损伤反应和蛋白质稳态调节蛋白,是 KRAS 突变型胰腺癌的潜在治疗靶点

Ye S Lee, Jennifer E Klomp, Clint A Stalnecker, Craig M Goodwin, Yanzhe Gao, Gaith N Droby, Cyrus Vaziri, Kirsten L Bryant, Channing J Der, Adrienne D Cox

RHOAL57V drives the development of diffuse gastric cancer through IGF1R-PAK1-YAP1 signaling

RHOAL57V通过IGF1R-PAK1-YAP1信号传导驱动弥漫性胃癌的发展

Antje Schaefer, Richard G Hodge, Haisheng Zhang, G Aaron Hobbs, Julien Dilly, Minh V Huynh, Craig M Goodwin, Feifei Zhang, J Nathaniel Diehl, Mariaelena Pierobon, Elisa Baldelli, Sehrish Javaid, Karson Guthrie, Naim U Rashid, Emanuel F Petricoin, Adrienne D Cox, William C Hahn, Andrew J Aguirre, Ada

Concurrent Inhibition of IGF1R and ERK Increases Pancreatic Cancer Sensitivity to Autophagy Inhibitors

同时抑制 IGF1R 和 ERK 可增加胰腺癌对自噬抑制剂的敏感性

Clint A Stalnecker, Kajal R Grover, A Cole Edwards, Michael F Coleman, Runying Yang, Jonathan M DeLiberty, Björn Papke, Craig M Goodwin, Mariaelena Pierobon, Emanuel F Petricoin, Prson Gautam, Krister Wennerberg, Adrienne D Cox, Channing J Der, Stephen D Hursting, Kirsten L Bryant

Vertical Inhibition of the RAF-MEK-ERK Cascade Induces Myogenic Differentiation, Apoptosis, and Tumor Regression in H/NRASQ61X Mutant Rhabdomyosarcoma

RAF-MEK-ERK 级联的垂直抑制可诱导 H/NRASQ61X 突变型横纹肌肉瘤的肌源性分化、细胞凋亡和肿瘤消退

Natalia Garcia, Vanessa Del Pozo, Marielle E Yohe, Craig M Goodwin, Terry J Shackleford, Long Wang, Kunal Baxi, Yidong Chen, Anna T Rogojina, Sara M Zimmerman, Cody J Peer, William D Figg, Myron S Ignatius, Kris C Wood, Peter J Houghton, Angelina V Vaseva

Functional and biological heterogeneity of KRASQ61 mutations

KRASQ61 突变的功能和生物学异质性

Minh V Huynh, G Aaron Hobbs, Antje Schaefer, Mariaelena Pierobon, Leiah M Carey, J Nathaniel Diehl, Jonathan M DeLiberty, Ryan D Thurman, Adelaide R Cooke, Craig M Goodwin, Joshua H Cook, Lin Lin, Andrew M Waters, Naim U Rashid, Emanuel F Petricoin 3rd, Sharon L Campbell, Kevin M Haigis, Diane M Sim

CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment

CHK1 保护致癌 KRAS 表达细胞免受 DNA 损伤,是胰腺癌治疗的靶点

Jennifer E Klomp, Ye S Lee, Craig M Goodwin, Björn Papke, Jeff A Klomp, Andrew M Waters, Clint A Stalnecker, Jonathan M DeLiberty, Kristina Drizyte-Miller, Runying Yang, J Nathaniel Diehl, Hongwei H Yin, Mariaelena Pierobon, Elisa Baldelli, Meagan B Ryan, Siqi Li, Jackson Peterson, Amber R Smith, Ja

Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition

靶向 p130Cas 和微管依赖性 MYC 调控使胰腺癌对 ERK MAPK 抑制敏感

Andrew M Waters, Tala O Khatib, Bjoern Papke, Craig M Goodwin, G Aaron Hobbs, J Nathaniel Diehl, Runying Yang, A Cole Edwards, Katherine H Walsh, Rita Sulahian, James M McFarland, Kevin S Kapner, Thomas S K Gilbert, Clint A Stalnecker, Sehrish Javaid, Anna Barkovskaya, Kajal R Grover, Priya S Hibshm

Detection of phenotype-specific therapeutic vulnerabilities in breast cells using a CRISPR loss-of-function screen

使用 CRISPR 功能丧失筛查检测乳腺细胞中表型特异性治疗脆弱性

Anna Barkovskaya, Craig M Goodwin, Kotryna Seip, Bylgja Hilmarsdottir, Solveig Pettersen, Clint Stalnecker, Olav Engebraaten, Eirikur Briem, Channing J Der, Siver A Moestue, Thorarinn Gudjonsson, Gunhild M Maelandsmo, Lina Prasmickaite

Atypical KRASG12R Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer

非典型 KRASG12R 突变体在胰腺癌中 PI3K 信号传导和巨胞饮作用受损

G Aaron Hobbs, Nicole M Baker, Anne M Miermont, Ryan D Thurman, Mariaelena Pierobon, Timothy H Tran, Andrew O Anderson, Andrew M Waters, J Nathaniel Diehl, Bjoern Papke, Richard G Hodge, Jennifer E Klomp, Craig M Goodwin, Jonathan M DeLiberty, Junning Wang, Raymond W S Ng, Prson Gautam, Kirsten L Br