日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

MNK Inhibition Sensitizes KRAS-Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression

MNK抑制通过降低eIF4E磷酸化和c-MYC表达,增强KRAS突变型结直肠癌对mTORC1抑制剂的敏感性。

John R P Knight ,Constantinos Alexandrou ,George L Skalka ,Nikola Vlahov ,Kathryn Pennel ,Leah Officer ,Ana Teodosio ,Georgios Kanellos ,David M Gay ,Sebastian May-Wilson ,Ewan M Smith ,Arafath K Najumudeen ,Kathryn Gilroy ,Rachel A Ridgway ,Dustin J Flanagan ,Rachael C L Smith ,Laura McDonald ,Craig MacKay ,Anne Cheasty ,Kerri McArthur ,Emma Stanway ,Joshua D Leach ,Rene Jackstadt ,Joseph A Waldron ,Andrew D Campbell ,Georgios Vlachogiannis ,Nicola Valeri ,Kevin M Haigis ,Nahum Sonenberg ,Christopher G Proud ,Neil P Jones ,Martin E Swarbrick ,Heather J McKinnon ,William J Faller ,John Le Quesne ,Joanne Edwards ,Anne E Willis ,Martin Bushell ,Owen J Sansom

Fadraciclib (CYC065), a novel CDK inhibitor, targets key pro-survival and oncogenic pathways in cancer

Fadraciclib (CYC065) 是一种新型 CDK 抑制剂,靶向癌症中的关键促生存和致癌途径

Sheelagh Frame, Chiara Saladino, Craig MacKay, Butrus Atrash, Peter Sheldrake, Edward McDonald, Paul A Clarke, Paul Workman, David Blake, Daniella Zheleva

Naturally complex: Perspectives and challenges associated with Botanical Dietary Supplement Safety assessment

自然而复杂:植物膳食补充剂安全性评估的视角与挑战

Shipkowski, Kelly A; Betz, Joseph M; Birnbaum, Linda S; Bucher, John R; Coates, Paul M; Hopp, D Craig; MacKay, Duffy; Oketch-Rabah, Hellen; Walker, Nigel J; Welch, Cara; Rider, Cynthia V

AluY-mediated germline deletion, duplication and somatic stem cell reversion in UBE2T defines a new subtype of Fanconi anemia

UBE2T 中 AluY 介导的生殖系缺失、重复和体细胞干细胞逆转定义了范康尼贫血的一种新亚型

Elizabeth L Virts, Anna Jankowska, Craig Mackay, Marcel F Glaas, Constanze Wiek, Stephanie L Kelich, Nadine Lottmann, Felicia M Kennedy, Christophe Marchal, Erik Lehnert, Rüdiger E Scharf, Carlo Dufour, Marina Lanciotti, Piero Farruggia, Alessandra Santoro, Süreyya Savasan, Kathrin Scheckenbach, Jör

Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2

鉴定 KIAA1018/FAN1,一种由单泛素化的 FANCD2 募集到 DNA 损伤处的 DNA 修复核酸酶

Craig MacKay, Anne-Cécile Déclais, Cecilia Lundin, Ana Agostinho, Andrew J Deans, Thomas J MacArtney, Kay Hofmann, Anton Gartner, Stephen C West, Thomas Helleday, David M J Lilley, John Rouse