日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Presence and distribution of progerin in HGPS cells is ameliorated by drugs that impact on the mevalonate and mTOR pathways

影响甲羟戊酸和 mTOR 通路的药物可改善 HGPS 细胞中早衰蛋白的存在和分布

Craig S Clements, Mehmet U Bikkul, Wendy Ofosu, Christopher Eskiw, David Tree, Evgeny Makarov, Ian R Kill, Joanna M Bridger

A ligand-induced structural change in fatty acid-binding protein 1 is associated with potentiation of peroxisome proliferator-activated receptor α agonists

脂肪酸结合蛋白 1 的配体诱导结构变化与过氧化物酶体增殖激活受体 α 激动剂的增强有关

Rahul Patil, Biswaranjan Mohanty, Bonan Liu, Indu R Chandrashekaran, Stephen J Headey, Martin L Williams, Craig S Clements, Olga Ilyichova, Bradley C Doak, Patrick Genissel, Richard J Weaver, Laurent Vuillard, Michelle L Halls, Christopher J H Porter, Martin J Scanlon

Farnesyltransferase inhibitor and rapamycin correct aberrant genome organisation and decrease DNA damage respectively, in Hutchinson-Gilford progeria syndrome fibroblasts

法呢基转移酶抑制剂和雷帕霉素分别纠正哈钦森-吉尔福德早衰综合征成纤维细胞中的异常基因组组织并减少 DNA 损伤

Mehmet U Bikkul, Craig S Clements, Lauren S Godwin, Martin W Goldberg, Ian R Kill, Joanna M Bridger

A conserved energetic footprint underpins recognition of human leukocyte antigen-E by two distinct αβ T cell receptors

保守的能量足迹支持两种不同的 αβ T 细胞受体识别人类白细胞抗原 E

Lucy C Sullivan, Nicholas G Walpole, Carine Farenc, Gabriella Pietra, Matthew J W Sum, Craig S Clements, Eleanor J Lee, Travis Beddoe, Michela Falco, Maria Cristina Mingari, Lorenzo Moretta, Stephanie Gras, Jamie Rossjohn, Andrew G Brooks0

The structure of the atypical killer cell immunoglobulin-like receptor, KIR2DL4

非典型杀伤细胞免疫球蛋白样受体 KIR2DL4 的结构

Shoeib Moradi, Richard Berry, Phillip Pymm, Corinne Hitchen, Simone A Beckham, Matthew C J Wilce, Nicholas G Walpole, Craig S Clements, Hugh H Reid, Matthew A Perugini, Andrew G Brooks, Jamie Rossjohn, Julian P Vivian

Killer cell immunoglobulin-like receptor 3DL1-mediated recognition of human leukocyte antigen B

杀伤细胞免疫球蛋白样受体 3DL1 介导的人类白细胞抗原 B 识别

Julian P Vivian, Renee C Duncan, Richard Berry, Geraldine M O'Connor, Hugh H Reid, Travis Beddoe, Stephanie Gras, Philippa M Saunders, Maya A Olshina, Jacqueline M L Widjaja, Christopher M Harpur, Jie Lin, Sebastien M Maloveste, David A Price, Bernard A P Lafont, Daniel W McVicar, Craig S Clements, 

Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability

细胞受体对主要组织相容性复合体的特异性硬接线由 TCR 适应性支撑

Scott R Burrows, Zhenjun Chen, Julia K Archbold, Fleur E Tynan, Travis Beddoe, Lars Kjer-Nielsen, John J Miles, Rajiv Khanna, Denis J Moss, Yu Chih Liu, Stephanie Gras, Lyudmila Kostenko, Rebekah M Brennan, Craig S Clements, Andrew G Brooks, Anthony W Purcell, James McCluskey, Jamie Rossjohn

Natural micropolymorphism in human leukocyte antigens provides a basis for genetic control of antigen recognition

人类白细胞抗原的天然微多态性为抗原识别的遗传控制提供了基础

Julia K Archbold, Whitney A Macdonald, Stephanie Gras, Lauren K Ely, John J Miles, Melissa J Bell, Rebekah M Brennan, Travis Beddoe, Matthew C J Wilce, Craig S Clements, Anthony W Purcell, James McCluskey, Scott R Burrows, Jamie Rossjohn

A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1d/glycolipid recognition

CD1d/糖脂识别中半不变 NKT 细胞受体的选择和跨物种反应的结构基础

Lars Kjer-Nielsen, Natalie A Borg, Daniel G Pellicci, Travis Beddoe, Lyudmila Kostenko, Craig S Clements, Nicholas A Williamson, Mark J Smyth, Gurdyal S Besra, Hugh H Reid, Mandvi Bharadwaj, Dale I Godfrey, Jamie Rossjohn, James McCluskey

Disparate thermodynamics governing T cell receptor-MHC-I interactions implicate extrinsic factors in guiding MHC restriction

控制 T 细胞受体-MHC-I 相互作用的不同热力学表明,外在因素在指导 MHC 限制

Lauren K Ely, Travis Beddoe, Craig S Clements, Jacqueline M Matthews, Anthony W Purcell, Lars Kjer-Nielsen, James McCluskey, Jamie Rossjohn