日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Age-associated mitochondrial DNA mutations cause metabolic remodelling that contributes to accelerated intestinal tumorigenesis

与年龄相关的线粒体 DNA 突变引起代谢重塑,从而加速肠道肿瘤发生

Anna Lm Smith #, Julia C Whitehall #, Carla Bradshaw, David Gay, Fiona Robertson, Alasdair P Blain, Gavin Hudson, Angela Pyle, David Houghton, Matthew Hunt, James N Sampson, Craig Stamp, Grace Mallett, Shoba Amarnath, Jack Leslie, Fiona Oakley, Laura Wilson, Angela Baker, Oliver M Russell, Riem John

Mitochondrial dysfunction impairs osteogenesis, increases osteoclast activity, and accelerates age related bone loss

线粒体功能障碍会损害成骨作用、增加破骨细胞活性并加速与年龄相关的骨质流失

Philip F Dobson, Ella P Dennis, Daniel Hipps, Amy Reeve, Alex Laude, Carla Bradshaw, Craig Stamp, Anna Smith, David J Deehan #, Doug M Turnbull #, Laura C Greaves #

Similar patterns of clonally expanded somatic mtDNA mutations in the colon of heterozygous mtDNA mutator mice and ageing humans

杂合线粒体DNA突变小鼠和老年人类结肠中克隆扩增的体细胞线粒体DNA突变模式相似

Holly L Baines,James B Stewart,Craig Stamp,Anze Zupanic,Thomas B L Kirkwood,Nils-Göran Larsson,Douglass M Turnbull,Laura C Greaves