日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Precision Labeling of Native Antibodies with Lock Coupling

利用锁偶联技术对天然抗体进行精确标记

Liu, Yazhi; Nadig, Isha; Mehta, Abijeet Singh; Chuo, Shih-Wei; Ho, Yen H; Tyler, James; Craik, Charles S; Anwar, Mekhail; Cohen, Bruce E

Discovery of Coronavirus Main Protease Inhibitors with Enhanced Brain Exposure and Potent Oral Efficacy in SARS-CoV-2 and MERS Infection Models

在SARS-CoV-2和MERS感染模型中发现具有增强脑暴露和强效口服疗效的冠状病毒主要蛋白酶抑制剂

Lizzadro, Luca; Li, Jiapeng; Taha, Taha Y; Degotte, Gilles; Detomasi, Tyler C; Zapatero-Belinchon, Francisco J; Hantz, Eric R; Huang, Sijie; Matsui, Yusuke; Henderson, Will R; McCann, Jack T; Montano, Mauricio; Rosecrans, Julia; Torres Pomares, Daniel F; McGovern, Briana L; Diaz-Tapia, Randy; Benjamin, Jared; Gordon, Mary E; Suazo, Isidora D; Settineri, Nicholas S; Diallo, Amy; Krogan, Nevan J; Shoichet, Brian K; Verba, Kliment A; Albrecht, Randy; García-Sastre, Adolfo; White, Kris M; Ott, Melanie; Craik, Charles S; Renslo, Adam R

Structure-guided design of a targeted autoantibody degrader for neurologic disease

基于结构的靶向自身抗体降解剂设计,用于治疗神经系统疾病

Zimanyi, Marcell; Dayao, Monica; Asencor, Andoni I; Kondapavulur, Sravani; Asaki, James; McCutcheon, Krista; Dabaco, Cristina; Bodansky, Aaron; Craik, Charles S; Pleasure, Samuel J; DeRisi, Joseph L; Cheng, Yifan; Wilson, Michael R; Pluvinage, John V

Structural Basis of Serine Protease Inhibition by Antibodies from Biased Fab Phage-Display Libraries

偏向性Fab噬菌体展示文库抗体抑制丝氨酸蛋白酶的结构基础

Anderson, Kyle J; Lee, Melody S; Sevillano, Natalia; Chen, Gang; Hornsby, Michael J; Sidhu, Sachdev S; Craik, Charles S

Coupling high-throughput protease enzymology with viral replication reveals biochemical constraints of viral fitness

将高通量蛋白酶酶学与病毒复制相结合,揭示了病毒适应性的生化限制。

Aidlen, Dylan; Vo, William Vinh Thanh; Young, Nicholas J; Rosecrans, Julia; Kurianowicz, Anna; Chuo, Shih-Wei; Asper, Garrison P R; Anderson, Dashiell; Posner, Jacob A; Muir, Duncan F; Freitas, Nicholas; Ott, Melanie; Craik, Charles S; Taha, Taha Y; Pinney, Margaux M

Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins.

亮氨酸氨肽酶 LyLAP 能够使溶酶体降解膜蛋白。

Jain Aakriti, Heremans Isaac, Rademaker Gilles, Detomasi Tyler C, Rohweder Peter, Anderson Dashiell, Zhang Justin, Hernandez Grace A, Gupta Suprit, von Linde Teresa, Lange Mike, Spacci Martina, Luo Jiayi, Citron Y Rose, Olzmann James A, Dawson David W, Craik Charles S, Bommer Guido, Perera Rushika M, Zoncu Roberto

Large Library Docking and Biophysical Analysis of Small-Molecule TMPRSS2 Inhibitors

大型化合物库对接及小分子TMPRSS2抑制剂的生物物理分析

Fraser, Bryan J; Young, Nicholas J; Bender, Brian J; Gahbauer, Stefan; Ilyassov, Olzhas; Wilson, Ryan P; Li, Yanjun; Seitova, Almagul; Lourenço, André Luiz; Chung, Dong Hee; Bardine, Conner; Bénard, François; Shoichet, Brian K; Craik, Charles S; Arrowsmith, Cheryl H

On-Resin Assembly of Macrocyclic Inhibitors of Cryptococcus neoformans May1: A Pathway to Potent Antifungal Agents.

新型隐球菌 May1 大环抑制剂的树脂上组装:通往强效抗真菌剂的途径

Kryštůfek Robin, Verner Václav, Šácha Pavel, Hadzima Martin, Trajhan Filip, Starková Jana, Tloušt'ová Eva, Dvořáková Alexandra, Pecina Adam, Brynda Jiří, Chalupský Karel, Hájek Miroslav, Boucher Michael J, Majer Pavel, Řezáč Jan, Madhani Hiten D, Craik Charles S, Konvalinka Jan

Identifying protease-activated targets and exploring therapeutic applications

鉴定蛋白酶激活靶点并探索其治疗应用

Kang, Deokhee; Craik, Charles S

Recombinant antibodies inhibit enzymatic activity of the E3 ubiquitin ligase CHIP via multiple mechanisms

重组抗体通过多种机制抑制E3泛素连接酶CHIP的酶活性。

Chung, Dong Hee; Connelly, Emily J; Unnikrishnan, Aparna; Chuo, Shih-Wei; Wucherer, Kristin; Nadel, Cory M; Gestwicki, Jason E; Southworth, Daniel R; Craik, Charles S