日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Multiscale modeling of the spatial structure of stem cells in neuroblastoma patient-derived tumoroids reveals a critical role for a short-range diffusive process.

对神经母细胞瘤患者来源的肿瘤类器官中干细胞的空间结构进行多尺度建模,揭示了短程扩散过程的关键作用。

Nguyen Thi Nhu Thao, Koering Catherine, Vallin Elodie, Gonin-Giraud Sandrine, Broutier Laura, Bernard Samuel, Crauste Fabien, Gandrillon Olivier

New pharmacodynamic parameters linked with ibrutinib responses in chronic lymphocytic leukemia: Prospective study in real-world patients and mathematical modeling

慢性淋巴细胞白血病中与伊布替尼疗效相关的新药效学参数:真实世界患者的前瞻性研究和数学建模

Cadot, Sarah; Audebert, Chloe; Dion, Charlotte; Ken, Soleakhena; Dupré, Loic; Largeaud, Laetitia; Laurent, Camille; Ysebaert, Loic; Crauste, Fabien; Quillet-Mary, Anne

Stochastic modeling of a gene regulatory network driving B cell development in germinal centers

对生发中心B细胞发育驱动基因调控网络的随机建模

Koshkin, Alexey; Herbach, Ulysse; Martínez, María Rodríguez; Gandrillon, Olivier; Crauste, Fabien

Practical identifiability in the frame of nonlinear mixed effects models: the example of the in vitro erythropoiesis

非线性混合效应模型框架下的实际可识别性:以体外红细胞生成为例

Duchesne, Ronan; Guillemin, Anissa; Gandrillon, Olivier; Crauste, Fabien

Modeling and characterization of inter-individual variability in CD8 T cell responses in mice.

小鼠 CD8 T 细胞反应个体间差异的建模与表征

Audebert Chloe, Laubreton Daphné, Arpin Christophe, Gandrillon Olivier, Marvel Jacqueline, Crauste Fabien

Multiscale Modeling of Germinal Center Recapitulates the Temporal Transition From Memory B Cells to Plasma Cells Differentiation as Regulated by Antigen Affinity-Based Tfh Cell Help

生发中心的多尺度建模重现了由抗原亲和力介导的Tfh细胞辅助调控的记忆B细胞向浆细胞分化的时间转变

Merino Tejero, Elena; Lashgari, Danial; García-Valiente, Rodrigo; Gao, Xuefeng; Crauste, Fabien; Robert, Philippe A; Meyer-Hermann, Michael; Martínez, María Rodríguez; van Ham, S Marieke; Guikema, Jeroen E J; Hoefsloot, Huub; van Kampen, Antoine H C

Drugs modulating stochastic gene expression affect the erythroid differentiation process

调节随机基因表达的药物会影响红系分化过程。

Guillemin, Anissa; Duchesne, Ronan; Crauste, Fabien; Gonin-Giraud, Sandrine; Gandrillon, Olivier

Calibration, Selection and Identifiability Analysis of a Mathematical Model of the in vitro Erythropoiesis in Normal and Perturbed Contexts

正常和扰动环境下体外红细胞生成数学模型的校准、选择和可识别性分析

Duchesne, Ronan; Guillemin, Anissa; Crauste, Fabien; Gandrillon, Olivier

IL-2 sensitivity and exogenous IL-2 concentration gradient tune the productive contact duration of CD8(+) T cell-APC: a multiscale modeling study

IL-2敏感性和外源性IL-2浓度梯度调节CD8(+) T细胞与APC的有效接触持续时间:一项多尺度建模研究

Gao, Xuefeng; Arpin, Christophe; Marvel, Jacqueline; Prokopiou, Sotiris A; Gandrillon, Olivier; Crauste, Fabien