日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A recipe for chaos: Extrachromosomal DNA and the hallmarks of cancer

混乱的根源:染色体外DNA与癌症的标志

Wong, Ivy Tsz-Lo; Bailey, Chris; Wu, Sihan; Henssen, Anton G; Cravatt, Benjamin F; Chen, Zhijian J; Bafna, Vineet; Jamal-Hanjani, Mariam; Swanton, Charlie; Chang, Howard Y; Mischel, Paul S

Mapping cellular targets of covalent cancer drugs in the entire mammalian body.

绘制共价抗癌药物在哺乳动物体内的细胞靶点图谱。

Pang Zhengyuan, Leung Verina H, Wang Cailynn C, Attarpour Ahmadreza, Rinaldi Anthony, Shen Hanbing, Moya-Garzon Maria Dolores, Sigua Logan H, Rammel Claire, Selke Alexandra, Glynn Christopher, Yender Melaina, Xu Senhan, Moslehi Javid J, Wu Peng, Long Jonathan Z, Goubran Maged, Cravatt Benjamin F, Ye Li

Integrated phenotypic screening and chemical proteomics identifies ETF1 ligands that modulate viral translation and replication.

整合表型筛选和化学蛋白质组学鉴定出调节病毒翻译和复制的 ETF1 配体。

Kim Arthur S, Ma Kevin, Reinhardt Christopher J, Lazar Daniel C, Ogasawara Daisuke, Shaw Teressa M, de la Torre Juan Carlos, Bailey Adam L, Melillo Bruno, Teijaro John R, Cravatt Benjamin F

Structural and mechanistic analysis of covalent ligands targeting the RNA-binding protein NONO.

针对 RNA 结合蛋白 NONO 的共价配体的结构和机制分析。

Lindsey Garrett L, Hockley Thomas K, Gomez Alejandro Villa, Marshall Andrew C, Brothers William R, Finney Colin T, Gross Jacob, Fox Archa H, Yeo Gene W, Melillo Bruno, Bond Charles S, Cravatt Benjamin F

Ophiobolin A impacts mitochondrial redox biology in an epithelial-mesenchymal transition (EMT)-specific manner.

Ophiobolin A 以上皮-间质转化 (EMT) 特异性方式影响线粒体氧化还原生物学。

Parker Haleigh N, Tao Yongfeng, Tobin Jenna, Haberman Kayla L, Davis Samantha, York Emily, Martinez Alysia, Matsumoto Nobuyuki, Aroujo Jaquelin, Park Jun Hyoung, Zechmann Bernd, Kaipparettu Benny Abraham, Boari Angela, Sayes Christie M, Evidente Antonio, Kornienko Alexander, Cravatt Benjamin, Romo Daniel, Taube Joseph H

Cysteine Reactivity Profiling Identifies Host Regulators of Mycobacterium tuberculosis Replication in Human Macrophages

半胱氨酸反应性分析揭示人类巨噬细胞中结核分枝杆菌复制的宿主调节因子

Neff, John K; DeMeester, Kristen E; Párraga Solórzano, Paola K; Suciu, Radu M; Dix, Melissa M; Simon, Gabriel; Gianakopoulos, Max A; Melillo, Bruno; Cravatt, Benjamin F; Shiloh, Michael U

A Global Ligandability Map of Tryptoline Butynamide Stereoprobes Identifies Covalent Inhibitors of the Actin Maturation Protease ACTMAP

色氨酸丁酰胺立体探针的全球配体结合能力图谱鉴定出肌动蛋白成熟蛋白酶ACTMAP的共价抑制剂

Xiong, Yijun; Reinhardt, Christopher J; Nguyen, Tracey; Hoffman, Melissa A; Simon, Gabriel M; Melillo, Bruno; Cravatt, Benjamin F

Genetic and pharmacological inactivation of peptidoglycan remodeling increases antibiotic susceptibility of vancomycin-resistant Enterococcus faecium

通过基因和药理学手段抑制肽聚糖重塑可提高耐万古霉素粪肠球菌对抗生素的敏感性。

Fam, Kyong T; Chodisetti, Pavan Kumar; Wang, Zifei; Homer, Joshua A; Smedley, Christopher J; Kitamura, Seiya; Silva, Benjamin; Xiong, Yijun; Hansel-Harris, Althea; Holcomb, Matthew; Babarinde, Simeon; Turner, Adrianna M; Van Tyne, Daria; Wilson, Ian A; Forli, Stefano; Cravatt, Benjamin F; Park, Donghyun; Wolan, Dennis W; Moses, John E; Hang, Howard C

Scalable total synthesis of saxitoxin and related natural products

可规模化合成石房蛤毒素及相关天然产物

Guo, Yinliang; Li, Yiheng; Chen, Sihan; Wu, Yige; Poll, Oscar; Ren, Zhouyang; Liu, Zhonglin; Vlkolinsky, Roman; Bajo, Michal; Prier, Christopher K; Xiao, Kai-Jiong; Cravatt, Benjamin F; Roberto, Marisa; Baran, Phil S

Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function

线粒体ABHD11抑制驱动甾醇代谢,从而调节T细胞效应功能

Benjamin J Jenkins # ,Yasmin R Jenkins # ,Fernando M Ponce-Garcia ,Chloe Moscrop ,Iain A Perry ,Matthew D Hitchings ,Alejandro H Uribe ,Federico Bernuzzi ,Simon Eastham ,James G Cronin ,Ardena Berisha ,Alexandra Howell ,Joanne Davies ,Julianna Blagih ,Marta Williams ,Morgan Marsden ,Douglas J Veale ,Luke C Davies ,Micah Niphakis ,David K Finlay ,Linda V Sinclair ,Benjamin F Cravatt ,Andrew E Hogan ,James A Nathan ,Ian R Humphreys ,Ursula Fearon ,David Sumpton ,Johan Vande Voorde ,Goncalo Dias do Vale ,Jeffrey G McDonald ,Gareth W Jones ,James A Pearson ,Emma E Vincent ,Nicholas Jones