日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A recipe for chaos: Extrachromosomal DNA and the hallmarks of cancer

混乱的根源:染色体外DNA与癌症的标志

Wong, Ivy Tsz-Lo; Bailey, Chris; Wu, Sihan; Henssen, Anton G; Cravatt, Benjamin F; Chen, Zhijian J; Bafna, Vineet; Jamal-Hanjani, Mariam; Swanton, Charlie; Chang, Howard Y; Mischel, Paul S

Mapping cellular targets of covalent cancer drugs in the entire mammalian body.

绘制共价抗癌药物在哺乳动物体内的细胞靶点图谱。

Pang Zhengyuan, Leung Verina H, Wang Cailynn C, Attarpour Ahmadreza, Rinaldi Anthony, Shen Hanbing, Moya-Garzon Maria Dolores, Sigua Logan H, Rammel Claire, Selke Alexandra, Glynn Christopher, Yender Melaina, Xu Senhan, Moslehi Javid J, Wu Peng, Long Jonathan Z, Goubran Maged, Cravatt Benjamin F, Ye Li

Complexoform-restricted covalent TRMT112 ligands that allosterically agonize METTL5

具有复合物形式限制的共价TRMT112配体,可变构激动METTL5

Goetzke, F Wieland; Bernard, Steffen M; Ju, Cheng-Wei; Pollock, Jonathan; DeMeester, Kristen E; Gross, Jacob; Simon, Gabriel M; He, Chuan; Melillo, Bruno; Cravatt, Benjamin F

Integrated phenotypic screening and chemical proteomics identifies ETF1 ligands that modulate viral translation and replication.

整合表型筛选和化学蛋白质组学鉴定出调节病毒翻译和复制的 ETF1 配体。

Kim Arthur S, Ma Kevin, Reinhardt Christopher J, Lazar Daniel C, Ogasawara Daisuke, Shaw Teressa M, de la Torre Juan Carlos, Bailey Adam L, Melillo Bruno, Teijaro John R, Cravatt Benjamin F

Structural and mechanistic analysis of covalent ligands targeting the RNA-binding protein NONO.

针对 RNA 结合蛋白 NONO 的共价配体的结构和机制分析。

Lindsey Garrett L, Hockley Thomas K, Gomez Alejandro Villa, Marshall Andrew C, Brothers William R, Finney Colin T, Gross Jacob, Fox Archa H, Yeo Gene W, Melillo Bruno, Bond Charles S, Cravatt Benjamin F

Cysteine Reactivity Profiling Identifies Host Regulators of Mycobacterium tuberculosis Replication in Human Macrophages

半胱氨酸反应性分析揭示人类巨噬细胞中结核分枝杆菌复制的宿主调节因子

Neff, John K; DeMeester, Kristen E; Párraga Solórzano, Paola K; Suciu, Radu M; Dix, Melissa M; Simon, Gabriel; Gianakopoulos, Max A; Melillo, Bruno; Cravatt, Benjamin F; Shiloh, Michael U

A chemical-genetic interaction between PAF1 and ENL/AF9 YEATS inhibition

PAF1与ENL/AF9 YEATS抑制之间的化学遗传相互作用

Barta, Paige A; Garnar-Wortzel, Leopold; Bishop, Timothy R; Hayward, Rachel E; Hargis, Lauren M; Shaum, James B; Kwok, Hui Si; Liau, Brian B; Cravatt, Benjamin F; Erb, Michael A

Dissecting FOXA1 pioneering function by acute pharmacological degradation

通过急性药理降解来解析FOXA1的先锋功能

Hargis, Lauren M; Barta, Paige A; Zhang, Yuxiang; Hayward, Rachel E; Cravatt, Benjamin F; Erb, Michael A

A Global Ligandability Map of Tryptoline Butynamide Stereoprobes Identifies Covalent Inhibitors of the Actin Maturation Protease ACTMAP

色氨酸丁酰胺立体探针的全球配体结合能力图谱鉴定出肌动蛋白成熟蛋白酶ACTMAP的共价抑制剂

Xiong, Yijun; Reinhardt, Christopher J; Nguyen, Tracey; Hoffman, Melissa A; Simon, Gabriel M; Melillo, Bruno; Cravatt, Benjamin F

Genetic and pharmacological inactivation of peptidoglycan remodeling increases antibiotic susceptibility of vancomycin-resistant Enterococcus faecium

通过基因和药理学手段抑制肽聚糖重塑可提高耐万古霉素粪肠球菌对抗生素的敏感性。

Fam, Kyong T; Chodisetti, Pavan Kumar; Wang, Zifei; Homer, Joshua A; Smedley, Christopher J; Kitamura, Seiya; Silva, Benjamin; Xiong, Yijun; Hansel-Harris, Althea; Holcomb, Matthew; Babarinde, Simeon; Turner, Adrianna M; Van Tyne, Daria; Wilson, Ian A; Forli, Stefano; Cravatt, Benjamin F; Park, Donghyun; Wolan, Dennis W; Moses, John E; Hang, Howard C