日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

CAR-T-drug conjugate against solid tumor

CAR-T药物偶联物抗实体瘤

Xin, Shan; Feng, Yanzhi; Zhang, Feifei; Yu, Jiang; Dong, Chuanpeng; Tao, Bo; Tang, Kaiyuan; Wu, Qihao; Chen, Binfan; Ren, Ping; Verma, Nipun; Liu, Chuan; Suzuki, Kazushi; Ling, Xinyu; Park, Daniel; Kluger, Harriet; Crawford, Jason M; Fan, Rong; Zhou, Jiangbing; Chen, Sidi

Bacterial small molecule metabolites implicated in gastrointestinal cancer development

细菌小分子代谢产物与胃肠道癌症的发生发展有关

Turocy, Tayah; Crawford, Jason M

Three-component assembly and structure-function relationships of (-)-gukulenin A

(-)-古库列宁A的三组分组装和结构-功能关系

Gupta, Vaani; Wang, Zechun; Combs, Joshua B; Wright, Timothy; Chen, Lei; Lin, Boxu; Holmes, Ryan; Qin, Bo; Oh, Joonseok; Crawford, Jason M; Herzon, Seth B

Activity of GPCR-targeted drugs influenced by human gut microbiota metabolism

人类肠道菌群代谢影响GPCR靶向药物的活性

Wu, Qihao; Song, Deguang; Zhao, Yanyu; Verdegaal, Andrew A; Turocy, Tayah; Duncan-Lowey, Brianna; Goodman, Andrew L; Palm, Noah W; Crawford, Jason M

Tryptamine Metabolism and Functionalization in Gut Commensal Bacteria Expand Human Tryptamine Signaling Responses

肠道共生菌中色胺的代谢和功能化扩展了人类色胺信号传导反应

Park, Hyun Bong; Song, Deguang; Nguyen, Mytien; Palm, Noah W; Crawford, Jason M

Enterococcus faecalis-derived adenine enhances enterohaemorrhagic Escherichia coli Type 3 Secretion System-dependent virulence.

粪肠球菌衍生的腺嘌呤增强了肠出血性大肠杆菌3型分泌系统依赖性毒力

Martins Fernando H, Rosay Thibaut, Rajan Anubama, Carter Hannah E, Turocy Tayah, Mejia Andres, Crawford Jason M, Maresso Anthony W, Sperandio Vanessa

Mechanism of Action of KL-50, a Candidate Imidazotetrazine for the Treatment of Drug-Resistant Brain Cancers

KL-50(一种用于治疗耐药性脑癌的候选咪唑并四嗪类药物)的作用机制

Huseman, Eric D; Lo, Anna; Fedorova, Olga; Elia, James L; Gueble, Susan E; Lin, Kingson; Sundaram, Ranjini K; Oh, Joonseok; Liu, Jinchan; Menges, Fabian; Rees, Matthew G; Ronan, Melissa M; Roth, Jennifer A; Batista, Victor S; Crawford, Jason M; Pyle, Anna M; Bindra, Ranjit S; Herzon, Seth B

Proof-of-concept studies with a computationally designed M(pro) inhibitor as a synergistic combination regimen alternative to Paxlovid

概念验证研究采用计算机设计的M(pro)抑制剂作为协同联合治疗方案,替代Paxlovid。

Papini, Christina; Ullah, Irfan; Ranjan, Amalendu P; Zhang, Shuo; Wu, Qihao; Spasov, Krasimir A; Zhang, Chunhui; Mothes, Walther; Crawford, Jason M; Lindenbach, Brett D; Uchil, Pradeep D; Kumar, Priti; Jorgensen, William L; Anderson, Karen S

The Xenorhabdus nematophila LrhA transcriptional regulator modulates production of γ-keto-N-acyl amides with inhibitory activity against mutualistic host nematode egg hatching.

Xenorhabdus nematophila LrhA 转录调节因子调节 γ-酮-N-酰基酰胺的产生,对互利共生宿主线虫卵孵化具有抑制活性

Lam Yick Chong, Hamchand Randy, Mucci Nicholas C, Kauffman Sarah J, Dudkina Natavan, Reagle Emily V, Casanova-Torres Ángel M, DeCuyper Jessica, Chen Haiwei, Song Deguang, Thomas Michael G, Palm Noah W, Goodrich-Blair Heidi, Crawford Jason M

Gut microbes modulate (p)ppGpp during a time-restricted feeding regimen

肠道微生物在限时喂养方案中调节 (p)ppGpp

Ontai-Brenning, Amy; Hamchand, Randy; Crawford, Jason M; Goodman, Andrew L