日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Advances in LAG3 cancer immunotherapeutics

LAG3癌症免疫疗法的进展

Adam, Kieran; Butler, Samuel C; Workman, Creg J; Vignali, Dario A A

Regulatory T cells in the tumor microenvironment display a unique chromatin accessibility profile

肿瘤微环境中的调节性 T 细胞表现出独特的染色质可及性特征

Rebekah E Dadey, Jian Cui, Dhivyaa Rajasundaram, Hiroshi Yano, Chang Liu, Jonathan A Cohen, Andrew W Liu, Daniel H Kaplan, Creg J Workman, Dario A A Vignali

Neuronal LAG3 facilitates pathogenic α-synuclein neuron-to-neuron propagation

神经元 LAG3 促进致病性 α-突触核蛋白在神经元之间的传播

Xiuli Yang, Deok Jeong, Graziella Madeo, Ramhari Kumbhar, Ning Wang, Lili Niu, Junkai Hu, Shuya Li, Kundlik Gadhave, Rong Chen, Fatih Akkentli, Creg J Workman, Dario A A Vignali, Mingyao Ying, Antonello Bonci, Valina L Dawson, Ted M Dawson, Xiaobo Mao2

Blockade of LAG-3 and PD-1 leads to co-expression of cytotoxic and exhaustion gene modules in CD8+ T cells to promote antitumor immunity

阻断 LAG-3 和 PD-1 可导致 CD8+ T 细胞中细胞毒性基因模块和耗竭基因模块的共表达,从而促进抗肿瘤免疫。

Anthony R Cillo ,Carly Cardello ,Feng Shan ,Lilit Karapetyan ,Sheryl Kunning ,Cindy Sander ,Elizabeth Rush ,Arivarasan Karunamurthy ,Ryan C Massa ,Anjali Rohatgi ,Creg J Workman ,John M Kirkwood ,Tullia C Bruno ,Dario A A Vignali

LAG-3 and PD-1 synergize on CD8+ T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity

LAG-3 和 PD-1 在 CD8+ T 细胞上发挥协同作用,导致 T 细胞耗竭并抑制自分泌 IFN-γ 依赖性抗肿瘤免疫。

Lawrence P Andrews ,Samuel C Butler ,Jian Cui ,Anthony R Cillo ,Carly Cardello ,Chang Liu ,Erin A Brunazzi ,Andrew Baessler ,Bingxian Xie ,Sheryl R Kunning ,Shin Foong Ngiow ,Yinghui Jane Huang ,Sasikanth Manne ,Arlene H Sharpe ,Greg M Delgoffe ,E John Wherry ,John M Kirkwood ,Tulia C Bruno ,Creg J Workman ,Dario A A Vignali

Author Correction: Aplp1 interacts with Lag3 to facilitate transmission of pathologic α-synuclein

作者更正:Aplp1 与 Lag3 相互作用,促进病理性 α-突触核蛋白的传递。

Mao, Xiaobo; Gu, Hao; Kim, Donghoon; Kimura, Yasuyoshi; Wang, Ning; Xu, Enquan; Kumbhar, Ramhari; Ming, Xiaotian; Wang, Haibo; Chen, Chan; Zhang, Shengnan; Jia, Chunyu; Liu, Yuqing; Bian, Hetao; Karuppagounder, Senthilkumar S; Akkentli, Fatih; Chen, Qi; Jia, Longgang; Hwang, Heehong; Lee, Su Hyun; Ke, Xiyu; Chang, Michael; Li, Amanda; Yang, Jun; Rastegar, Cyrus; Sriparna, Manjari; Ge, Preston; Brahmachari, Saurav; Kim, Sangjune; Zhang, Shu; Shimoda, Yasushi; Saar, Martina; Liu, Haiqing; Kweon, Sin Ho; Ying, Mingyao; Workman, Creg J; Vignali, Dario A A; Muller, Ulrike C; Liu, Cong; Ko, Han Seok; Dawson, Valina L; Dawson, Ted M

Regulatory T Cell Insufficiency in Autoimmune Diabetes Is Driven by Selective Loss of Neuropilin-1 on Intraislet Regulatory T Cells

自身免疫性糖尿病中调节性T细胞功能不足是由胰岛内调节性T细胞上神经纤毛蛋白-1的选择性丢失所驱动的。

Stephanie Grebinoski ,Gwenyth Pieklo ,Qianxia Zhang ,Anabelle Visperas ,Jian Cui ,Jordana Goulet ,Hanxi Xiao ,Erin A Brunazzi ,Carly Cardello ,Andrés A Herrada ,Jishnu Das ,Creg J Workman ,Dario A A Vignali

Cutting Edge: LAG3 Dimerization Is Required for TCR/CD3 Interaction and Inhibition of Antitumor Immunity

前沿研究:LAG3二聚化是TCR/CD3相互作用和抑制抗肿瘤免疫所必需的

Adam, Kieran; Lipatova, Zhanna; Abdul Ghafoor Raja, Maria; Mishra, Arjun K; Mariuzza, Roy A; Workman, Creg J; Vignali, Dario A A

Lymphocyte-Activation Gene 3 Facilitates Pathological Tau Neuron-to-Neuron Transmission

淋巴细胞活化基因 3 促进病理性 Tau 神经元到神经元的传递

Chan Chen, Ramhari Kumbhar, Hu Wang, Xiuli Yang, Kundlik Gadhave, Cyrus Rastegar, Yasuyoshi Kimura, Adam Behensky, Sumasri Kotha, Grace Kuo, Sruthi Katakam, Deok Jeong, Liang Wang, Anthony Wang, Rong Chen, Shu Zhang, Lingtao Jin, Creg J Workman, Dario A A Vignali, Olga Pletinkova, Hongpeng Jia, Weiy

IFNγ-induction of TH1-like regulatory T cells controls antiviral responses

IFNγ诱导的TH1样调节性T细胞控制抗病毒反应

Angela M Gocher-Demske, Jian Cui, Andrea L Szymczak-Workman, Kate M Vignali, Julianna N Latini, Gwen P Pieklo, Jesse C Kimball, Lyndsay Avery, Ellyse M Cipolla, Brydie R Huckestein, Lee Hedden, Marlies Meisel, John F Alcorn, Lawrence P Kane, Creg J Workman, Dario A A Vignali