日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Exploration and Characterization of the Antimalarial Activity of Pyrimidine-2,4-Diamines for which Resistance is Mediated by the ABCI3 Transporter

探索和表征嘧啶-2,4-二胺的抗疟活性及其由ABCI3转运蛋白介导的耐药性

Mansouri, Mahta; Dans, Madeline G; Low, Zijun; Loi, Katie; Jarman, Kate E; Penington, Jocelyn S; Qiu, Deyun; Lehane, Adele M; Crespo, Benigno; Gamo, Franciso-Javier; Baud, Delphine; Brand, Stephen; Jackson, Paul F; Cowman, Alan F; Sleebs, Brad E

The critical role of PSAC channel in malaria parasite survival is driven home by phenotypic screening under relevant nutrient levels.

在相关营养水平下进行的表型筛选证实了 PSAC 通道在疟原虫存活中的关键作用

Molina Irene, Mansell Ryan, Liang Rui, Crespo Benigno, Puente Margarita, Franco Virginia, Viera Sara, Camino Isabel, Saadeddin Anas, Bellotti Peter, Leung Annie, Henning Sam, Sun Shan, Herring Mikayla, Lopez Celia, Cuevas Carmen, Pogány Peter, Urones Beatriz, Baxt Leigh, Fernández Esther, Geri Jacob, Kirkman Laura, Kafsack Björn F C, Mata-Cantero Lydia

Leveraging the Aggregated Protein Dye YAT2150 for Malaria Chemotherapy.

利用聚集蛋白染料YAT2150进行疟疾化疗

Camarero-Hoyos Claudia, Bouzón-Arnáiz Inés, Avalos-Padilla Yunuen, Fallica Antonino Nicolò, Román-Álamo Lucía, Ramírez Miriam, Portabella Emma, Cuspinera Ona, Currea-Ayala Daniela, Orozco-Quer Marc, Ribera Maria, Siden-Kiamos Inga, Spanos Lefteris, Iglesias Valentín, Crespo Benigno, Viera Sara, Andreu David, Sulleiro Elena, Zarzuela Francesc, Urtasun Nerea, Pérez-Torras Sandra, Pastor-Anglada Marçal, Arce Elsa M, Muñoz-Torrero Diego, Fernàndez-Busquets Xavier

A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo.

一种强效且选择性的恶性疟原虫酪氨酸 tRNA 合成酶反应劫持抑制剂在体内表现出单剂量口服疗效

Xie Stanley C, Tai Chia-Wei, Morton Craig J, Ma Liting, Huang Shih-Chung, Wittlin Sergio, Du Yawei, Hu Yongbo, Dogovski Con, Salimimarand Mina, Griffin Robert, England Dylan, de la Cruz Elisa, Deni Ioanna, Yeo Tomas, Burkhard Anna Y, Striepen Josefine, Schindler Kyra A, Crespo Benigno, Gamo Francisco J, Khandokar Yogesh, Hutton Craig A, Rabie Tayla, Birkholtz Lyn-Marié, Famodimu Mufuliat T, Delves Michael J, Bolsher Judith, Koolen Karin M J, van der Laak Rianne, Aguiar Anna C C, Pereira Dhelio B, Guido Rafael V C, Creek Darren J, Fidock David A, Dick Lawrence R, Brand Stephen L, Gould Alexandra E, Langston Steven, Griffin Michael D W, Tilley Leann

Structures revealing mechanisms of resistance and collateral sensitivity of Plasmodium falciparum to proteasome inhibitors

揭示恶性疟原虫对蛋白酶体抑制剂的耐药机制和协同敏感性的结构

Hsu, Hao-Chi; Li, Daqiang; Zhan, Wenhu; Ye, Jianxiang; Liu, Yi Jing; Leung, Annie; Qin, Junling; Crespo, Benigno; Gamo, Francisco-Javier; Zhang, Hao; Cui, Liwang; Roth, Alison; Kirkman, Laura A; Li, Huilin; Lin, Gang

Novel Antimalarial Tetrazoles and Amides Active against the Hemoglobin Degradation Pathway in Plasmodium falciparum

新型抗疟四唑类和酰胺类药物可有效抑制恶性疟原虫的血红蛋白降解途径

Lawong, Aloysus; Gahalawat, Suraksha; Okombo, John; Striepen, Josefine; Yeo, Tomas; Mok, Sachel; Deni, Ioanna; Bridgford, Jessica L; Niederstrasser, Hanspeter; Zhou, Anwu; Posner, Bruce; Wittlin, Sergio; Gamo, Francisco Javier; Crespo, Benigno; Churchyard, Alisje; Baum, Jake; Mittal, Nimisha; Winzeler, Elizabeth; Laleu, Benoît; Palmer, Michael J; Charman, Susan A; Fidock, David A; Ready, Joseph M; Phillips, Margaret A

Substituted Aminoacetamides as Novel Leads for Malaria Treatment

取代氨基乙酰胺作为疟疾治疗的新型先导化合物

Norcross, Neil R; Wilson, Caroline; Baragaña, Beatriz; Hallyburton, Irene; Osuna-Cabello, Maria; Norval, Suzanne; Riley, Jennifer; Fletcher, Daniel; Sinden, Robert; Delves, Michael; Ruecker, Andrea; Duffy, Sandra; Meister, Stephan; Antonova-Koch, Yevgeniya; Crespo, Benigno; de Cózar, Cristina; Sanz, Laura M; Gamo, Francisco Javier; Avery, Vicky M; Frearson, Julie A; Gray, David W; Fairlamb, Alan H; Winzeler, Elizabeth A; Waterson, David; Campbell, Simon F; Willis, Paul A; Read, Kevin D; Gilbert, Ian H

Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles

开源药物发现:源自 Tres Cantos 芳基吡咯的高效抗疟化合物

Williamson, Alice E; Ylioja, Paul M; Robertson, Murray N; Antonova-Koch, Yevgeniya; Avery, Vicky; Baell, Jonathan B; Batchu, Harikrishna; Batra, Sanjay; Burrows, Jeremy N; Bhattacharyya, Soumya; Calderon, Felix; Charman, Susan A; Clark, Julie; Crespo, Benigno; Dean, Matin; Debbert, Stefan L; Delves, Michael; Dennis, Adelaide S M; Deroose, Frederik; Duffy, Sandra; Fletcher, Sabine; Giaever, Guri; Hallyburton, Irene; Gamo, Francisco-Javier; Gebbia, Marinella; Guy, R Kiplin; Hungerford, Zoe; Kirk, Kiaran; Lafuente-Monasterio, Maria J; Lee, Anna; Meister, Stephan; Nislow, Corey; Overington, John P; Papadatos, George; Patiny, Luc; Pham, James; Ralph, Stuart A; Ruecker, Andrea; Ryan, Eileen; Southan, Christopher; Srivastava, Kumkum; Swain, Chris; Tarnowski, Matthew J; Thomson, Patrick; Turner, Peter; Wallace, Iain M; Wells, Timothy N C; White, Karen; White, Laura; Willis, Paul; Winzeler, Elizabeth A; Wittlin, Sergio; Todd, Matthew H

Identifying rapidly parasiticidal anti-malarial drugs using a simple and reliable in vitro parasite viability fast assay

利用一种简单可靠的体外寄生虫活力快速检测方法,快速筛选具有杀灭寄生虫作用的抗疟药物。

Linares, María; Viera, Sara; Crespo, Benigno; Franco, Virginia; Gómez-Lorenzo, María G; Jiménez-Díaz, María Belén; Angulo-Barturen, Íñigo; Sanz, Laura María; Gamo, Francisco-Javier

Fueling open-source drug discovery: 177 small-molecule leads against tuberculosis

推动开源药物发现:177 个抗结核小分子先导化合物

Ballell, Lluís; Bates, Robert H; Young, Rob J; Alvarez-Gomez, Daniel; Alvarez-Ruiz, Emilio; Barroso, Vanessa; Blanco, Delia; Crespo, Benigno; Escribano, Jaime; González, Rubén; Lozano, Sonia; Huss, Sophie; Santos-Villarejo, Angel; Martín-Plaza, José Julio; Mendoza, Alfonso; Rebollo-Lopez, María José; Remuiñan-Blanco, Modesto; Lavandera, José Luis; Pérez-Herran, Esther; Gamo-Benito, Francisco Javier; García-Bustos, José Francisco; Barros, David; Castro, Julia P; Cammack, Nicholas