日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Negative Selection Maintains Grossly Altered but Broadly Stable Karyotypes in Metastatic Colorectal Cancer

负选择维持转移性结直肠癌中显著改变但总体稳定的核型

Cross, William C H; Nowinski, Salpie; Cresswell, George D; Mossner, Maximilian; Banerjee, Abhirup; Lu, Bingxin; Williams, Marc J; Vlachogiannis, Georgios; Gay, Laura J; Baker, Ann-Marie; Kimberley, Christopher; Whiting, Frederick J H; Belnoue-Davis, Hayley L; Martinez, Pierre; Traki, Maria; Walther, Viola; Smith, Kane; Fernandez-Mateos, Javier; Yara-Romero, Erika; Oliveira, Erica A; Milite, Salvatore; Caravagna, Giulio; James, Chela T; Elia, George; Berner, Alison; Ryan Choi, Chang-Ho; Ramagiri, Pradeep; Chauhan, Ritika; Matthews, Nik; Murphy, Jamie; Antoniou, Anthony; Clark, Susan K; Mitchison, Miriam; Chin Aleong, Jo-Anne; Domingo, Enric; Spiteri, Inmaculada; McDonald, Stuart A C; Shibata, Darryl; Laclé, Miangela M; Wang, Lai Mun; Moorghen, Morgan; Tomlinson, Ian P M; Novelli, Marco; Jansen, Marnix; Watson, Alan; Valeri, Nicola; Wright, Nicholas A; Bridgewater, John A; Rodriguez-Justo, Manuel; Barnes, Chris P; Kocher, Hemant M; Leedham, Simon J; Sottoriva, Andrea; Graham, Trevor A

Epigenetically driven and early immune evasion in colorectal cancer evolution

表观遗传驱动和早期免疫逃逸在结直肠癌演变中的作用

Lakatos, Eszter; Gunasri, Vinaya; Zapata, Luis; Househam, Jacob; Heide, Timon; Trahearn, Nicholas; Swinyard, Ottilie; Cisneros, Luis; Lynn, Claire; Mossner, Maximilian; Kimberley, Chris; Spiteri, Inmaculada; Cresswell, George D; Llibre-Palomar, Gerard; Mitchison, Miriam; Maley, Carlo C; Jansen, Marnix; Rodriguez-Justo, Manuel; Bridgewater, John; Baker, Ann-Marie; Sottoriva, Andrea; Graham, Trevor A

Low-coverage whole genome sequencing of low-grade dysplasia strongly predicts advanced neoplasia risk in ulcerative colitis.

低覆盖率全基因组测序可以强有力地预测溃疡性结肠炎中低级别发育不良的进展为肿瘤的风险

Al Bakir Ibrahim, Curtius Kit, Cresswell George D, Grant Heather E, Nasreddin Nadia, Smith Kane, Nowinski Salpie, Guo Qingli, Belnoue-Davis Hayley L, Fisher Jennifer, Clarke Theo, Kimberley Christopher, Mossner Maximilian, Dunne Philip D, Loughrey Maurice B, Speight Ally, East James E, Wright Nicholas A, Rodriguez-Justo Manuel, Jansen Marnix, Moorghen Morgan, Baker Ann-Marie, Leedham Simon J, Hart Ailsa L, Graham Trevor A

Epigenetic Heritability of Cell Plasticity Drives Cancer Drug Resistance through a One-to-Many Genotype-to-Phenotype Paradigm.

细胞可塑性的表观遗传性通过一对多的基因型到表型范式驱动癌症耐药性

Oliveira Erica A, Milite Salvatore, Fernandez-Mateos Javier, Cresswell George D, Yara-Romero Erika, Vlachogiannis Georgios, Chen Bingjie, James Chela T, Patruno Lucrezia, Ascolani Gianluca, Acar Ahmet, Heide Timon, Spiteri Inmaculada, Graudenzi Alex, Caravagna Giulio, Bertotti Andrea, Graham Trevor A, Magnani Luca, Valeri Nicola, Sottoriva Andrea

Epigenome and early selection determine the tumour-immune evolutionary trajectory of colorectal cancer

表观基因组和早期选择决定了结直肠癌的肿瘤免疫进化轨迹

Lakatos, Eszter; Gunasri, Vinaya; Zapata, Luis; Househam, Jacob; Heide, Timon; Trahearn, Nicholas; Swinyard, Ottilie; Cisneros, Luis; Lynn, Claire; Mossner, Maximilian; Kimberley, Chris; Spiteri, Inmaculada; Cresswell, George D; Llibre-Palomar, Gerard; Mitchison, Miriam; Maley, Carlo C; Jansen, Marnix; Rodriguez-Justo, Manuel; Bridgewater, John; Baker, Ann-Marie; Sottoriva, Andrea; Graham, Trevor A

Phenotypic plasticity and genetic control in colorectal cancer evolution

结直肠癌演化中的表型可塑性和遗传控制

Househam, Jacob; Heide, Timon; Cresswell, George D; Spiteri, Inmaculada; Kimberley, Chris; Zapata, Luis; Lynn, Claire; James, Chela; Mossner, Maximilian; Fernandez-Mateos, Javier; Vinceti, Alessandro; Baker, Ann-Marie; Gabbutt, Calum; Berner, Alison; Schmidt, Melissa; Chen, Bingjie; Lakatos, Eszter; Gunasri, Vinaya; Nichol, Daniel; Costa, Helena; Mitchinson, Miriam; Ramazzotti, Daniele; Werner, Benjamin; Iorio, Francesco; Jansen, Marnix; Caravagna, Giulio; Barnes, Chris P; Shibata, Darryl; Bridgewater, John; Rodriguez-Justo, Manuel; Magnani, Luca; Sottoriva, Andrea; Graham, Trevor A

EGFR amplification and outcome in a randomised phase III trial of chemotherapy alone or chemotherapy plus panitumumab for advanced gastro-oesophageal cancers

EGFR扩增与晚期胃食管癌患者接受单纯化疗或化疗联合帕尼单抗治疗的随机III期试验结果

Smyth, Elizabeth C; Vlachogiannis, Georgios; Hedayat, Somaieh; Harbery, Alice; Hulkki-Wilson, Sanna; Salati, Massimiliano; Kouvelakis, Kyriakos; Fernandez-Mateos, Javier; Cresswell, George D; Fontana, Elisa; Seidlitz, Therese; Peckitt, Clare; Hahne, Jens C; Lampis, Andrea; Begum, Ruwaida; Watkins, David; Rao, Sheela; Starling, Naureen; Waddell, Tom; Okines, Alicia; Crosby, Tom; Mansoor, Was; Wadsley, Jonathan; Middleton, Gary; Fassan, Matteo; Wotherspoon, Andrew; Braconi, Chiara; Chau, Ian; Vivanco, Igor; Sottoriva, Andrea; Stange, Daniel E; Cunningham, David; Valeri, Nicola

Pervasive chromosomal instability and karyotype order in tumour evolution

肿瘤演化中普遍存在的染色体不稳定性及核型有序性

Watkins, Thomas B K; Lim, Emilia L; Petkovic, Marina; Elizalde, Sergi; Birkbak, Nicolai J; Wilson, Gareth A; Moore, David A; Grönroos, Eva; Rowan, Andrew; Dewhurst, Sally M; Demeulemeester, Jonas; Dentro, Stefan C; Horswell, Stuart; Au, Lewis; Haase, Kerstin; Escudero, Mickael; Rosenthal, Rachel; Bakir, Maise Al; Xu, Hang; Litchfield, Kevin; Lu, Wei Ting; Mourikis, Thanos P; Dietzen, Michelle; Spain, Lavinia; Cresswell, George D; Biswas, Dhruva; Lamy, Philippe; Nordentoft, Iver; Harbst, Katja; Castro-Giner, Francesc; Yates, Lucy R; Caramia, Franco; Jaulin, Fanny; Vicier, Cécile; Tomlinson, Ian P M; Brastianos, Priscilla K; Cho, Raymond J; Bastian, Boris C; Dyrskjøt, Lars; Jönsson, Göran B; Savas, Peter; Loi, Sherene; Campbell, Peter J; Andre, Fabrice; Luscombe, Nicholas M; Steeghs, Neeltje; Tjan-Heijnen, Vivianne C G; Szallasi, Zoltan; Turajlic, Samra; Jamal-Hanjani, Mariam; Van Loo, Peter; Bakhoum, Samuel F; Schwarz, Roland F; McGranahan, Nicholas; Swanton, Charles

Subclonal reconstruction of tumors by using machine learning and population genetics

利用机器学习和群体遗传学进行肿瘤亚克隆重建

Caravagna, Giulio; Heide, Timon; Williams, Marc J; Zapata, Luis; Nichol, Daniel; Chkhaidze, Ketevan; Cross, William; Cresswell, George D; Werner, Benjamin; Acar, Ahmet; Chesler, Louis; Barnes, Chris P; Sanguinetti, Guido; Graham, Trevor A; Sottoriva, Andrea

Mapping the breast cancer metastatic cascade onto ctDNA using genetic and epigenetic clonal tracking

利用遗传和表观遗传克隆追踪技术,将乳腺癌转移级联过程映射到ctDNA上。

Cresswell, George D; Nichol, Daniel; Spiteri, Inmaculada; Tari, Haider; Zapata, Luis; Heide, Timon; Maley, Carlo C; Magnani, Luca; Schiavon, Gaia; Ashworth, Alan; Barry, Peter; Sottoriva, Andrea