日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Orthosteric STING inhibition elucidates molecular correction of SAVI STING.

正构 STING 抑制阐明了 SAVI STING 的分子矫正

Xie Tao, Ruzanov Max, Critton David, Merselis Leidy, Naglich Joseph, Sack John S, Zhang Ping, Xie Chunshan, Tredup Jeffrey, Stine Laurel B, Messier Cameron, Hope David L, Caceres-Cortes Janet, Mueller Luciano, Dyckman Alaric J, Newitt John A, Choudhury Asmita, Wilson Stephen C

Structure-Based Design of Novel TLR7/8 Agonist Payloads Enabling an Immunomodulatory Conjugate Approach

基于结构的新型TLR7/8激动剂有效载荷设计,可实现免疫调节偶联物策略

Poudel, Yam B; Lo, Julian C; Norris, Derek J; Cox, Matthew; He, Liqi; Johnson, Walter L; A M Subbaiah, Murugaiah; Mondal, Santigopal; Thangavel, Soodamani; Subramani, Lakshumanan; Reddy, Maheswara; Jain, Suraksha; Weiss, Dahlia R; Sivaprakasam, Prasanna; Critton, David; Mulligan, Dawn; Xie, Chunshan; Dhar, Payal; Li, Yvonne; Sega, Emanuela; Yamazoe, Sayumi; Gavai, Ashvinikumar V; Mathur, Arvind; Zapf, Christoph W; Chekler, Eugene P

Discovery of Novel TLR7 Agonists as Systemic Agent for Combination With aPD1 for Use in Immuno-oncology

发现新型TLR7激动剂作为全身性药物与抗PD-1抗体联合用于免疫肿瘤学

Poudel, Yam B; He, Liqi; Cox, Matthew; Zhang, Qian; Johnson, Walter L; Cong, Qiang; Cheng, Heng; Chowdari, Naidu S; Tarby, Christine; Donnell, Andrew F; Broekema, Matthais; O'Malley, Daniel P; Zhang, Yong; A M Subbaiah, Murugaiah; Kumar, Boda Vijay; Subramani, Lakshumanan; Wang, Bei; Li, Yi-Xin; Sivaprakasam, Prasanna; Critton, David; Mulligan, Dawn; Sandhu, Bhupindar; Xie, Chunshan; Ramakrishnan, Radha; Nagar, Jignesh; Dudhgaonkar, Shailesh; Oderinde, Martins S; Murtaza, Anwar; Schieven, Gary L; Mathur, Arvind; Gavai, Ashvinikumar V; Vite, Gregory; Gangwar, Sanjeev

Identification and Optimization of Small Molecule Pyrazolopyrimidine TLR7 Agonists for Applications in Immuno-oncology

鉴定和优化小分子吡唑并嘧啶类TLR7激动剂在免疫肿瘤学中的应用

He, Liqi; Zhang, Meng Yao; Cox, Matthew; Zhang, Qian; Donnell, Andrew F; Zhang, Yong; Tarby, Christine; Gill, Patrice; Subbaiah, Murugaiah A M; Ramar, Thangeswaran; Reddy, Maheswara; Puttapaka, Vijaya; Li, Yi-Xin; Sivaprakasam, Prasanna; Critton, David; Mulligan, Dawn; Xie, Chunshan; Ramakrishnan, Radha; Nagar, Jignesh; Dudhgaonkar, Shailesh; Murtaza, Anwar; Oderinde, Martins S; Schieven, Gary L; Mathur, Arvind; Gavai, Ashvinikumar V; Vite, Gregory; Gangwar, Sanjeev; Poudel, Yam B

Discovery of Pyridazinone and Pyrazolo[1,5-a]pyridine Inhibitors of C-Terminal Src Kinase

发现吡啶酮和吡唑并[1,5-a]吡啶类C端Src激酶抑制剂

O'Malley, Daniel P; Ahuja, Vijay; Fink, Brian; Cao, Carolyn; Wang, Cindy; Swanson, Jesse; Wee, Susan; Gavai, Ashvinikumar V; Tokarski, John; Critton, David; Paiva, Anthony A; Johnson, Benjamin M; Szapiel, Nicolas; Xie, Dianlin

Protein tyrosine phosphatases: structure, function, and implication in human disease

蛋白质酪氨酸磷酸酶:结构、功能及其在人类疾病中的作用

Tautz, Lutz; Critton, David A; Grotegut, Stefan

Inhibition of hematopoietic protein tyrosine phosphatase augments and prolongs ERK1/2 and p38 activation

抑制造血蛋白酪氨酸磷酸酶可增强和延长 ERK1/2 和 p38 活化

Eduard Sergienko, Jian Xu, Wallace H Liu, Russell Dahl, David A Critton, Ying Su, Brock T Brown, Xochella Chan, Li Yang, Ekaterina V Bobkova, Stefan Vasile, Hongbin Yuan, Justin Rascon, Sharon Colayco, Shyama Sidique, Nicholas D P Cosford, Thomas D Y Chung, Tomas Mustelin, Rebecca Page, Paul J Lombr

Visualizing active-site dynamics in single crystals of HePTP: opening of the WPD loop involves coordinated movement of the E loop

HePTP单晶中活性位点动力学的可视化:WPD环的打开涉及E环的协同运动

Critton, David A; Tautz, Lutz; Page, Rebecca

Spinophilin directs protein phosphatase 1 specificity by blocking substrate binding sites

棘蛋白通过阻断底物结合位点来调控蛋白磷酸酶1的特异性。

Ragusa, Michael J; Dancheck, Barbara; Critton, David A; Nairn, Angus C; Page, Rebecca; Peti, Wolfgang

Structural basis of substrate recognition by hematopoietic tyrosine phosphatase

造血酪氨酸磷酸酶底物识别的结构基础

David A Critton, Antoni Tortajada, Geoffrey Stetson, Wolfgang Peti, Rebecca Page