日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Predicting epistasis across proteins by structural logic

利用结构逻辑预测蛋白质间的上位性

Tang, Michelle; Cromie, Gareth A; Kabir, Anowarul; Timour, Martin S; Ashmead, Julee; Lo, Russell S; Corley, Nathaniel; DiMaio, Frank; Morizono, Hiroki; Caldovic, Ljubica; Ah Mew, Nicholas; Gropman, Andrea; Shehu, Amarda; Dudley, Aimée M

Two commonly reported incidental variants in OTC are associated with late-onset disease

OTC基因中两种常见的偶然变异与晚发性疾病相关。

Lang, Steven H; Lo, Russell S; Cromie, Gareth A; Dudley, Aimée M; Mew, Nicholas Ah; Simpson, Kara; Sutton, Vernon Reid; Darilek, Sandra; Ali, Saima; Snyder, Matthew T; Lee, Brendan; Marom, Ronit; Nagamani, Sandesh C S; Burrage, Lindsay C

A hypomorphic model of CPS1 deficiency for investigating the effects of hyperammonemia on the developing nervous system.

CPS1 缺陷的低效模型,用于研究高氨血症对发育中神经系统的影响

Bakshi Stuti, Diep Taryn, Willis Brandon J, Reyes Rachel, Wu Grace F, Makris Georgios, Poms Martin, Day Isabel, Sun Qin, Zhuravka Irina, Lueptow Lindsay, Tang Michelle, Cromie Gareth A, Dudley Aimée M, Häberle Johannes, Lipshutz Gerald S

CYClones: A highly powered, fully genotyped, 8-parent yeast mapping population

CYClones:一个高效率、完全基因分型的8亲本酵母作图群体

Cromie, Gareth A; Lo, Russell S; Morgan, Trey S; Clark, Anne E; Ashmead, Julee; Timour, Martin S; Sirr, Amy; Akey, Joshua M; Dudley, Aimée M

Pervasive context-dependent effects in the genetic architecture of complex and quantitative traits revealed by a powerful multiparent mapping population in yeast

利用强大的多亲本作图群体在酵母中揭示了复杂性状和数量性状的遗传结构中普遍存在的上下文依赖性效应

Cromie, Gareth A; Lo, Russell S; Ames, Lauren; Morgan, Trey S; Owens, Katherine; Clark, Anne E; Timour, Martin S; Ashmead, Julee; Tang, Michelle; Kutz, J Nathan; Akey, Joshua M; Dudley, Aimée M

Spatiotemporal patterns of gene expression during development of a complex colony morphology

复杂菌落形态发育过程中基因表达的时空模式

Cromie, Gareth A; Tan, Zhihao; Hays, Michelle; Sirr, Amy; Dudley, Aimée M

The functional impact of 1,570 individual amino acid substitutions in human OTC

1570个氨基酸替换对人类OTC的功能影响

Lo, Russell S; Cromie, Gareth A; Tang, Michelle; Teng, Kevin; Owens, Katherine; Sirr, Amy; Kutz, J Nathan; Morizono, Hiroki; Caldovic, Ljubica; Ah Mew, Nicholas; Gropman, Andrea; Dudley, Aimée M

Constructing and interpreting a large-scale variant effect map for an ultrarare disease gene: Comprehensive prediction of the functional impact of PSAT1 genotypes

构建和解读超罕见病基因的大规模变异效应图谱:PSAT1基因型功能影响的全面预测

Xie, Michael J; Cromie, Gareth A; Owens, Katherine; Timour, Martin S; Tang, Michelle; Kutz, J Nathan; El-Hattab, Ayman W; McLaughlin, Richard N Jr; Dudley, Aimée M

Predicting the functional effect of compound heterozygous genotypes from large scale variant effect maps

利用大规模变异效应图谱预测复合杂合基因型的功能效应

Xie, Michael J; Cromie, Gareth A; Owens, Katherine; Timour, Martin S; Tang, Michelle; Kutz, J Nathan; El-Hattab, Ayman W; McLaughlin, Richard N; Dudley, Aimée M

A yeast-based complementation assay elucidates the functional impact of 200 missense variants in human PSAT1

基于酵母的互补试验阐明了人类PSAT1中200个错义变异的功能影响

Sirr, Amy; Lo, Russell S; Cromie, Gareth A; Scott, Adrian C; Ashmead, Julee; Heyesus, Mirutse; Dudley, Aimée M