日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

IL-9 as a naturally orthogonal cytokine with optimal JAK/STAT signaling for engineered T cell therapy

IL-9 作为一种天然正交细胞因子,具有最佳的 JAK/STAT 信号通路活性,可用于工程化 T 细胞治疗。

Jiang, Hua; Limsuwannarot, Sam; Kulhanek, Kayla R; Pal, Aastha; Rysavy, Lea W; Su, Leon; Labiad, Ossama; Testa, Stefano; Ogana, Heather; Waghray, Deepa; Tao, Pingdong; Jude, Kevin M; Seet, Christopher S; Crooks, Gay M; Moding, Everett J; Garcia, K Christopher; Kalbasi, Anusha

IRIS: Discovery of cancer immunotherapy targets arising from pre-mRNA alternative splicing

IRIS:发现源于前体mRNA选择性剪接的癌症免疫治疗靶点

Pan, Yang; Phillips, John W; Zhang, Beatrice D; Noguchi, Miyako; Kutschera, Eric; McLaughlin, Jami; Nesterenko, Pavlo A; Mao, Zhiyuan; Bangayan, Nathanael J; Wang, Robert; Tran, Wendy; Yang, Harry T; Wang, Yuanyuan; Xu, Yang; Obusan, Matthew B; Cheng, Donghui; Lee, Alex H; Kadash-Edmondson, Kathryn E; Champhekar, Ameya; Puig-Saus, Cristina; Ribas, Antoni; Prins, Robert M; Seet, Christopher S; Crooks, Gay M; Witte, Owen N; Xing, Yi

Purine nucleoside phosphorylase enables dual metabolic checkpoints that prevent T cell immunodeficiency and TLR7-associated autoimmunity

嘌呤核苷磷酸化酶能够实现双重代谢检查点,从而预防T细胞免疫缺陷和TLR7相关的自身免疫性疾病。

Abt, Evan R; Rashid, Khalid; Le, Thuc M; Li, Suwen; Lee, Hailey R; Lok, Vincent; Li, Luyi; Creech, Amanda L; Labora, Amanda N; Mandl, Hanna K; Lam, Alex K; Cho, Arthur; Rezek, Valerie; Wu, Nanping; Abril-Rodriguez, Gabriel; Rosser, Ethan W; Mittelman, Steven D; Hugo, Willy; Mehrling, Thomas; Bantia, Shanta; Ribas, Antoni; Donahue, Timothy R; Crooks, Gay M; Wu, Ting-Ting; Radu, Caius G

High Interferon Signature Leads to Increased STAT1/3/5 Phosphorylation in PBMCs From SLE Patients by Single Cell Mass Cytometry

单细胞质谱流式细胞术分析显示,高干扰素特征导致系统性红斑狼疮患者外周血单核细胞中STAT1/3/5磷酸化水平升高。

Yiu, Gloria; Rasmussen, Tue Kruse; Tsai, Brandon L; Diep, Vivian K; Haddon, David J; Tsoi, Jennifer; Miller, Gopika D; Comin-Anduix, Begoña; Deleuran, Bent; Crooks, Gay M; Utz, Paul J

Autologous Ex Vivo Lentiviral Gene Therapy for Adenosine Deaminase Deficiency

自体体外慢病毒基因疗法治疗腺苷脱氨酶缺乏症

Kohn, Donald B; Booth, Claire; Shaw, Kit L; Xu-Bayford, Jinhua; Garabedian, Elizabeth; Trevisan, Valentina; Carbonaro-Sarracino, Denise A; Soni, Kajal; Terrazas, Dayna; Snell, Katie; Ikeda, Alan; Leon-Rico, Diego; Moore, Theodore B; Buckland, Karen F; Shah, Ami J; Gilmour, Kimberly C; De Oliveira, Satiro; Rivat, Christine; Crooks, Gay M; Izotova, Natalia; Tse, John; Adams, Stuart; Shupien, Sally; Ricketts, Hilory; Davila, Alejandra; Uzowuru, Chilenwa; Icreverzi, Amalia; Barman, Provaboti; Campo Fernandez, Beatriz; Hollis, Roger P; Coronel, Maritess; Yu, Allen; Chun, Krista M; Casas, Christian E; Zhang, Ruixue; Arduini, Serena; Lynn, Frances; Kudari, Mahesh; Spezzi, Andrea; Zahn, Marco; Heimke, Rene; Labik, Ivan; Parrott, Roberta; Buckley, Rebecca H; Reeves, Lilith; Cornetta, Kenneth; Sokolic, Robert; Hershfield, Michael; Schmidt, Manfred; Candotti, Fabio; Malech, Harry L; Thrasher, Adrian J; Gaspar, H Bobby

IND-Enabling Studies for a Clinical Trial to Genetically Program a Persistent Cancer-Targeted Immune System

IND申报研究,旨在开展一项临床试验,通过基因编程构建持久性癌症靶向免疫系统。

Puig-Saus, Cristina; Parisi, Giulia; Garcia-Diaz, Angel; Krystofinski, Paige E; Sandoval, Salemiz; Zhang, Ruixue; Champhekar, Ameya S; McCabe, James; Cheung-Lau, Gardenia C; Truong, Nhat A; Vega-Crespo, Agustin; Komenan, Marie Desiles S; Pang, Jia; Macabali, Mignonette H; Saco, Justin D; Goodwin, Jeffrey L; Bolon, Brad; Seet, Christopher S; Montel-Hagen, Amelie; Crooks, Gay M; Hollis, Roger P; Campo-Fernandez, Beatriz; Bischof, Daniela; Cornetta, Kenneth; Gschweng, Eric H; Adelson, Celia; Nguyen, Alexander; Yang, Lili; Witte, Owen N; Baltimore, David; Comin-Anduix, Begonya; Kohn, Donald B; Wang, Xiaoyan; Cabrera, Paula; Kaplan-Lefko, Paula J; Berent-Maoz, Beata; Ribas, Antoni

Myeloid Disease Mutations of Splicing Factor SRSF2 Cause G2-M Arrest and Skewed Differentiation of Human Hematopoietic Stem and Progenitor Cells

剪接因子SRSF2的髓系疾病突变导致人类造血干细胞和祖细胞G2-M期阻滞和分化异常

Bapat, Aditi; Keita, Nakia; Martelly, William; Kang, Paul; Seet, Christopher; Jacobsen, Jeffery R; Stoilov, Peter; Hu, Chengcheng; Crooks, Gay M; Sharma, Shalini

Generation of mature T cells from human hematopoietic stem and progenitor cells in artificial thymic organoids

利用人工胸腺类器官从人类造血干细胞和祖细胞生成成熟T细胞

Seet, Christopher S; He, Chongbin; Bethune, Michael T; Li, Suwen; Chick, Brent; Gschweng, Eric H; Zhu, Yuhua; Kim, Kenneth; Kohn, Donald B; Baltimore, David; Crooks, Gay M; Montel-Hagen, Amélie

BALR-6 regulates cell growth and cell survival in B-lymphoblastic leukemia

BALR-6 调控 B 淋巴母细胞白血病中的细胞生长和细胞存活

Rodríguez-Malavé, Norma I; Fernando, Thilini R; Patel, Parth C; Contreras, Jorge R; Palanichamy, Jayanth Kumar; Tran, Tiffany M; Anguiano, Jaime; Davoren, Michael J; Alberti, Michael O; Pioli, Kimanh T; Sandoval, Salemiz; Crooks, Gay M; Rao, Dinesh S

Dynamics of HSPC repopulation in nonhuman primates revealed by a decade-long clonal-tracking study

一项长达十年的克隆追踪研究揭示了非人灵长类动物造血干细胞再生的动态过程

Kim, Sanggu; Kim, Namshin; Presson, Angela P; Metzger, Mark E; Bonifacino, Aylin C; Sehl, Mary; Chow, Samson A; Crooks, Gay M; Dunbar, Cynthia E; An, Dong Sung; Donahue, Robert E; Chen, Irvin S Y