日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A phase 1, multicenter, open-label study to evaluate the pharmacokinetics, safety, and tolerability of a single dose of rimegepant in children (aged ≥6 to <12 years) with a history of migraine

一项 1 期、多中心、开放标签研究,旨在评估单剂量瑞美吉泮在有偏头痛病史的儿童(年龄 ≥6 岁至 <12 岁)中的药代动力学、安全性和耐受性。

Lim, Chay Ngee; Mo, Gary; Bhardwaj, Rajinder; Comisar, Craig M; Emerson, Beth L; Matschke, Kyle T; Fisniku, Ogert; Bertz, Richard; Croop, Robert; Liu, Jing

A 52-week open-label extension study to evaluate the safety and efficacy of oral rimegepant for the preventive treatment of migraine

一项为期 52 周的开放标签扩展研究,旨在评估口服瑞美吉泮预防偏头痛的安全性和有效性

Kudrow, David; Croop, Robert S; Thiry, Alexandra; Lipton, Richard B

A Phase 1, Randomized, Placebo-Controlled, Multiple-Dose, Double-Blind Study to Evaluate and Compare the Pharmacokinetics and Safety of Rimegepant in Healthy Adult Japanese and Caucasian Individuals

一项 1 期随机、安慰剂对照、多剂量、双盲研究,旨在评估和比较瑞美吉泮在健康日本成年人和白种人中的药代动力学和安全性。

Bhardwaj, Rajinder; Lim, Chay Ngee; Li, Yinhua; Matschke, Kyle T; Bertz, Richard; Croop, Robert; Liu, Jing

Characterization of rimegepant drug-drug interactions using the cytochrome P450 probe drugs, itraconazole, rifampin, fluconazole, and midazolam

利用细胞色素P450探针药物伊曲康唑、利福平、氟康唑和咪达唑仑对瑞美吉泮的药物相互作用进行表征

Bhardwaj, Rajinder; Morris, Beth; Matschke, Kyle T; Bertz, Richard; Croop, Robert; Liu, Jing

Assessment of pharmacokinetic and pharmacodynamic interactions between zavegepant and sumatriptan: A phase 1, randomized, placebo-controlled study in healthy adults

评估扎维吉泮和舒马曲坦之间的药代动力学和药效学相互作用:一项在健康成人中进行的 I 期随机、安慰剂对照研究

Bhardwaj, Rajinder; Donohue, Mary K; Madonia, Jennifer; Matschke, Kyle; Anderson, Matt S; Morris, Beth; Bertz, Richard; Croop, Robert; Liu, Jing

Efficacy and safety of rimegepant for the preventive treatment of migraine in Japan: A double-blind, randomized controlled trial

瑞美吉泮在日本预防性治疗偏头痛的疗效和安全性:一项双盲随机对照试验

Kitamura, Shigekazu; Matsumori, Yasuhiko; Yamamoto, Toshimasa; Ishikawa, Tomofumi; Hoshino, Yuko; Yoshimatsu, Hiroki; Thiry, Alexandra; Arakawa, Akio; Croop, Robert; Fullerton, Terence; Sakai, Fumihiko; Takeshima, Takao

Safety, tolerability, and pharmacokinetics of single and multiple ascending doses of zavegepant nasal spray in healthy adults from two phase 1 randomized, placebo-controlled trials

两项 1 期随机、安慰剂对照试验评估了健康成年人单次和多次递增剂量扎维吉泮鼻喷雾剂的安全性、耐受性和药代动力学

Bertz, Richard; Donohue, Mary; Madonia, Jennifer; Bhardwaj, Rajinder; Matschke, Kyle T; Anderson, Matt S; Croop, Robert; Liu, Jing

The influence of renal impairment on the pharmacokinetics of rimegepant: Results of a phase 1, open-label, single-dose, parallel-group study

肾功能损害对瑞美吉泮药代动力学的影响:一项 1 期开放标签、单剂量、平行组研究的结果

Bhardwaj, Rajinder; Morris, Beth; Bertz, Richard; Matschke, Kyle; Croop, Robert; Liu, Jing

Efficacy and safety of rimegepant for the acute treatment of migraine in Japan: A dose-ranging, double-blind, randomized controlled trial

瑞美吉泮治疗日本急性偏头痛的疗效和安全性:一项剂量范围、双盲、随机对照试验

Ikeda, Koichi; Matsumori, Yasuhiko; Kudo, Masako; Ishikawa, Tomofumi; Hoshino, Yuko; Yoshimatsu, Hiroki; Thiry, Alexandra; Arakawa, Akio; Croop, Robert; Fullerton, Terence; Sakai, Fumihiko; Takeshima, Takao

A Phase 1/2 Study of Lenvatinib in Combination With Everolimus in Recurrent and Refractory Pediatric and Young Adult Solid Tumors

乐伐替尼联合依维莫司治疗复发性和难治性儿童及青少年实体瘤的1/2期研究

Dela Cruz, Filemon S; Fox, Elizabeth; DuBois, Steven G; Friedman, Gregory K; Croop, James M; Kim, AeRang; Morgenstern, Daniel A; Balis, Frank M; Macy, Margaret E; Pressey, Joseph G; Watt, Tanya; Krystal, Julie I; Vo, Kieuhoa T; Mody, Rajen; Laetsch, Theodore W; Weigel, Brenda J; O'Hara, Karen; He, Cixin S; Aluri, Jagadeesh; Okpara, Chinyere E; Glade Bender, Julia L