日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Novel roles of DNA glycosylases in neurodegenerative diseases and aging

DNA糖基化酶在神经退行性疾病和衰老中的新作用

Tiwari, Vinod; Borbolis, Fivos; Croteau, Deborah L; Palikaras, Konstantinos; Bohr, Vilhelm A

Cockayne syndrome mice reflect human kidney disease and are defective in de novo NAD biosynthesis.

科凯恩综合征小鼠反映了人类肾脏疾病,并且在从头合成 NAD 方面存在缺陷。

Pekhale Komal, Tiwari Vinod, Hussain Mansoor, Bridges Christy C, Croteau Deborah L, Levi Moshe, Rosenberg Avi Z, Santo Briana, Yang Xiaoping, Kulikowicz Tomasz, Wang Xiaoxin X, Lee Jong-Hyuk, Bohr Vilhelm A

Spatial transcriptomics reveals an unexpected impact of tau and tau pathology on the expression of transthyretin

空间转录组学揭示了tau蛋白及其病理对转甲状腺素蛋白表达的意外影响

Croteau, Deborah L; Navarro, Jose Fernandez; Comptdaer, Thomas; Andrusivova, Zaneta; Jurek, Aleksandra; Bonnefoy, Eliette; Buée, Luc; Bohr, Vilhelm A; Lundeberg, Joakim; Galas, Marie-Christine

Telomere attrition alters extracellular vesicles conferring adverse impacts on neuronal viability and inflammatory response.

端粒损耗会改变细胞外囊泡,从而对神经元活力和炎症反应产生不利影响

Gong Yi, Wang Yunong, Delgado-Peraza Francheska, Nogueras-Ortiz Carlos, Noren Hooten Nicole, Croteau Deborah L, Temre Mithlesh, Molnar Abigail E, Bodogai Monica, Zou Ainslee, Abdelmohsen Kotb, Zhu Wei, Zhang Yongqing, Gorospe Myriam, Weng Nan-Ping, Evans Michele K, Kapogiannis Dimitrios, Liu Yie

Mitochondrial accumulation and lysosomal dysfunction result in mitochondrial plaques in Alzheimer's disease

线粒体积聚和溶酶体功能障碍会导致阿尔茨海默病中出现线粒体斑块。

Dan, Xiuli; Croteau, Deborah L; Liu, Wenlong; Chu, Xixia; Robbins, Paul D; Bohr, Vilhelm A

Loss of DNA glycosylases improves health and cognitive function in a C. elegans model of human tauopathy

在秀丽隐杆线虫的人类tau蛋白病模型中,DNA糖基化酶的缺失可改善健康和认知功能。

Tiwari, Vinod; Buvarp, Elisabeth; Borbolis, Fivos; Puligilla, Chandrakala; Croteau, Deborah L; Palikaras, Konstantinos; Bohr, Vilhelm A

Loss of smelling is an early marker of aging and is associated with inflammation and DNA damage in C57BL/6J mice

嗅觉丧失是衰老的早期标志,并且与C57BL/6J小鼠的炎症和DNA损伤有关。

Dan, Xiuli; Yang, Beimeng; McDevitt, Ross A; Gray, Samuel; Chu, Xixia; Claybourne, Quia; Figueroa, David M; Zhang, Yongqing; Croteau, Deborah L; Bohr, Vilhelm A

Nicotinamide adenine dinucleotide supplementation drives gut microbiota variation in Alzheimer's mouse model

烟酰胺腺嘌呤二核苷酸补充剂可驱动阿尔茨海默病小鼠模型肠道菌群的变化

Chu, Xixia; Hou, Yujun; Meng, Qiong; Croteau, Deborah L; Wei, Yong; De, Supriyo; Becker, Kevin G; Bohr, Vilhelm A

Olfactory dysfunction in aging and neurodegenerative diseases

衰老和神经退行性疾病中的嗅觉功能障碍

Dan, Xiuli; Wechter, Noah; Gray, Samuel; Mohanty, Joy G; Croteau, Deborah L; Bohr, Vilhelm A

NAD(+) supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer's disease via cGAS-STING

在阿尔茨海默病转基因小鼠模型中,NAD(+)补充剂可通过cGAS-STING途径减少神经炎症和细胞衰老。

Hou, Yujun; Wei, Yong; Lautrup, Sofie; Yang, Beimeng; Wang, Yue; Cordonnier, Stephanie; Mattson, Mark P; Croteau, Deborah L; Bohr, Vilhelm A