日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Decreased metallothionein-3 expression in the human spinal cord is a common feature of amyotrophic lateral sclerosis and multiple sclerosis.

人类脊髓中金属硫蛋白-3表达降低是肌萎缩侧索硬化症和多发性硬化症的共同特征。

Gunn Adam P, Hilton James B W, Mukherjee Soumya, Liddell Jeffrey R, Mercer Stephen W, McLean Catriona A, Masters Colin L, Crouch Peter J, Roberts Blaine R

A polytherapy approach demonstrates therapeutic efficacy for the treatment of SOD1 associated amyotrophic lateral sclerosis.

多药联合疗法对治疗 SOD1 相关肌萎缩侧索硬化症具有疗效

Lum Jeremy S, Brown Mikayla L, Farrawell Natalie E, Bartlett Rachael, Chisholm Christen G, Gorman Jody, Dosseto Anthony, Dux Florian, McInnes Lachlan E, Ecroyd Heath, McAlary Luke, Crouch Peter J, Donnelly Paul S, Yerbury Justin J

The structure, redox chemistry and motor neuron toxicity of heterodimeric zinc-deficient SOD1-implications for the toxic gain of function observed in ALS

异二聚体锌缺乏型SOD1的结构、氧化还原化学性质及其对运动神经元的毒性——对ALS中观察到的毒性功能获得的意义

Streltsov, Victor A; Ganio, Katherine E; Nuttall, Stewart D; Hernandez, J Andres; Dennys, Cassandra N; Crouch, Peter J; Estevez, Alvaro G; Franco, Maria Clara; Beckman, Joseph S; Roberts, Blaine R

The structure, redox chemistry and motor neuron toxicity of heterodimeric zinc-deficient SOD1-Implications for the toxic gain of function observed in ALS

异二聚体锌缺乏型SOD1的结构、氧化还原化学性质及其对运动神经元的毒性——对ALS中观察到的毒性功能获得性的启示

Streltsov, Victor A; Ganio, Katherine E; Nuttall, Stewart D; Hernandez, J Andres; Dennys, Cassandra N; Crouch, Peter J; Estevez, Alvaro G; Franco, Maria Clara; Beckman, Joseph S; Roberts, Blaine R

Superoxide Dismutase 1 in Health and Disease: How a Frontline Antioxidant Becomes Neurotoxic

超氧化物歧化酶 1 在健康和疾病中的作用:一线抗氧化剂如何变成神经毒性物质

Trist, Benjamin G; Hilton, James B; Hare, Dominic J; Crouch, Peter J; Double, Kay L

An integrated mass spectrometry imaging and digital pathology workflow for objective detection of colorectal tumours by unique atomic signatures

利用独特的原子特征对结直肠肿瘤进行客观检测的集成质谱成像和数字病理工作流程

Paul, Bence; Kysenius, Kai; Hilton, James B; Jones, Michael W M; Hutchinson, Robert W; Buchanan, Daniel D; Rosty, Christophe; Fryer, Fred; Bush, Ashley I; Hergt, Janet M; Woodhead, Jon D; Bishop, David P; Doble, Philip A; Hill, Michelle M; Crouch, Peter J; Hare, Dominic J

SLN124, a GalNac-siRNA targeting transmembrane serine protease 6, in combination with deferiprone therapy reduces ineffective erythropoiesis and hepatic iron-overload in a mouse model of β-thalassaemia

SLN124 是一种靶向跨膜丝氨酸蛋白酶 6 的 GalNac-siRNA,与去铁酮联合治疗可减少 β-地中海贫血小鼠模型中的无效红细胞生成和肝脏铁过载。

Vadolas, Jim; Ng, Garrett Z; Kysenius, Kai; Crouch, Peter J; Dames, Sibylle; Eisermann, Mona; Nualkaew, Tiwaporn; Vilcassim, Shahla; Schaeper, Ute; Grigoriadis, George

Copper-ATSM as a Treatment for ALS: Support from Mutant SOD1 Models and Beyond

铜-ATSM作为ALS的治疗方法:来自突变型SOD1模型及其他研究的支持

Nikseresht, Sara; Hilton, James B W; Kysenius, Kai; Liddell, Jeffrey R; Crouch, Peter J

Cu(II)(atsm) improves the neurological phenotype and survival of SOD1(G93A) mice and selectively increases enzymatically active SOD1 in the spinal cord

Cu(II)(atsm)可改善SOD1(G93A)小鼠的神经表型和存活率,并选择性地增加脊髓中具有酶活性的SOD1。

Hilton, James B; Mercer, Stephen W; Lim, Nastasia K H; Faux, Noel G; Buncic, Gojko; Beckman, Joseph S; Roberts, Blaine R; Donnelly, Paul S; White, Anthony R; Crouch, Peter J

Imaging Metals in Brain Tissue by Laser Ablation - Inductively Coupled Plasma - Mass Spectrometry (LA-ICP-MS)

利用激光烧蚀-电感耦合等离子体质谱法(LA-ICP-MS)对脑组织中的金属进行成像

Hare, Dominic J; Kysenius, Kai; Paul, Bence; Knauer, Beate; Hutchinson, Robert W; O'Connor, Ciaran; Fryer, Fred; Hennessey, Tom P; Bush, Ashley I; Crouch, Peter J; Doble, Philip A