日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Methylene Peptide Backbone Substitution Significantly Affects the Glycopeptide Antibiotic Cross-Linking Cascade

亚甲基肽骨架取代显著影响糖肽类抗生素交联级联反应

Gullick, Jemma; Marschall, Edward; Tucker, Sam; Schittenhelm, Ralf B; Malins, Lara R; Tailhades, Julien; Cryle, Max J

Biosynthesis of Biphenomycin-like Macrocyclic Peptides by Formation and Cross-Linking of Ortho-Tyrosines

通过邻位酪氨酸的形成和交联合成双苯霉素样大环肽

Padhi, Chandrashekhar; Zhu, Lingyang; Chen, Jeff Y; Huang, Chuan; Moreira, Ryan; Challis, Gregory L; Cryle, Max J; van der Donk, Wilfred A

SRP19 and the protein secretion machinery is a targetable vulnerability in cancers with APC loss.

SRP19 和蛋白质分泌机制是 APC 缺失的癌症中可靶向的脆弱点

Xi Xinqi, Liu Ling, Tuano Natasha, Tailhades Julien, Mouradov Dmitri, Steen Jason, Sieber Oliver, Cryle Max, Nguyen-Dumont Tu, Segelov Eva, Rosenbluh Joseph

An integrated multi-omic approach for discovery and dereplication of bioactive microbial natural products

一种用于发现和去重复鉴定生物活性微生物天然产物的综合多组学方法

Negeri, Negero Gemeda; Nguyen, Duong Duc Anh; Michael, Michael; Kenshole, Emma; Walsh, Calum; Judd, Louise M; Sharkey, Liam K R; Zeng, Weiguang; Stinear, Timothy P; Herisse, Marion; Huang, Chuan; Cryle, Max J; Pidot, Sacha J

A randomised controlled clinical and cost effectiveness trial of an online integrated bipolar parenting intervention (IBPI) compared to treatment as usual in improving child emotional and behavioural outcomes: a study protocol

一项随机对照临床及成本效益试验,比较在线综合双相情感障碍养育干预(IBPI)与常规治疗在改善儿童情绪和行为结果方面的效果:研究方案

Jones, Steven H; Byford, Sarah; Coleman, Elizabeth; Creswell, Cathy; Cryle, Lucy; Duffy, Anne; Fortier, Stephanie; Hewitt, Catherine E; Lobban, Fiona; Lodge, Christopher; Morriss, Richard; Palmier-Claus, Jasper; Sinclair, Lesley; Sutton, Christopher J; Watson, Judith; Yaziji, Nahel; Kerry, Eirian

Teicoplanin Nonribosomal Peptide Synthetase Is Unable to Incorporate Alpha-Ketoacid Building Blocks

替考拉宁非核糖体肽合成酶无法掺入α-酮酸结构单元

Ratnayake, Minuri S; Jian, Xinyun; Tailhades, Julien; Challis, Gregory L; Hansen, Mathias H; Lewandowski, Józef R; Cryle, Max J

The Biarylitides: Understanding the Structure and Biosynthesis of a Fascinating Class of Cytochrome P450 Modified RiPP Natural Products

双芳基酯:了解一类引人入胜的细胞色素P450修饰的RiPP天然产物的结构和生物合成

Padva, Leo; Gullick, Jemma; Coe, Laura J; Hansen, Mathias H; De Voss, James J; Crüsemann, Max; Cryle, Max J

Correction: Synthetic ramoplanin analogues are accessible by effective incorporation of arylglycines in solid-phase peptide synthesis

更正:通过在固相肽合成中有效引入芳基甘氨酸,可以合成拉莫普兰宁类似物。

Marschall, Edward; Cass, Rachel W; Prasad, Komal M; Swarbrick, James D; McKay, Alasdair I; Payne, Jennifer A E; Cryle, Max J; Tailhades, Julien

An Engineered Biarylitide Cross-Linking P450 from RiPP Biosynthesis Generates Alternative Cyclic Peptides

来自 RiPP 生物合成的工程化双芳基肽交联 P450 可生成替代环肽

Treisman, Maxine; Coe, Laura; Zhao, Yongwei; Sasi, Vishnu Mini; Gullick, Jemma; Hansen, Mathias H; Ly, Aviva; Leichthammer, Victor; Hess, Caroline; Machell, Daniel L; Schittenhelm, Ralf B; Hooper, Joel; Jackson, Colin J; Tailhades, Julien; De Voss, James J; Cryle, Max J

Altering glycopeptide antibiotic biosynthesis through mutasynthesis allows incorporation of fluorinated phenylglycine residues

通过诱变合成改变糖肽抗生素的生物合成可以加入氟化苯甘氨酸残基

Irina Voitsekhovskaia, Y T Candace Ho, Christoph Klatt, Anna Müller, Daniel L Machell, Yi Jiun Tan, Maxine Triesman, Mara Bingel, Ralf B Schittenhelm, Julien Tailhades, Andreas Kulik, Martin E Maier, Gottfried Otting, Wolfgang Wohlleben, Tanja Schneider, Max Cryle, Evi Stegmann