CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify KDM3B as a Genotype-specific Vulnerability in IDH2- and TET2-mutant Cells.
在原代造血干细胞中进行的 CRISPR 依赖性筛选发现 KDM3B 是 IDH2 和 TET2 突变细胞中的基因型特异性脆弱性
期刊:Cancer Discovery
影响因子:33.3
doi:10.1158/2159-8290.CD-23-1092
Waarts Michael R, Mowla Shoron, Boileau Meaghan, Martinez Benitez Anthony R, Sango Junya, Bagish Maya, Fernández-Maestre Inés, Shan Yufan, Eisman Shira E, Park Young C, Wereski Matthew, Csete Isabelle, O'Connor Kavi, Romero-Vega Angelica C, Miles Linde A, Xiao Wenbin, Wu Xiaodi, Koche Richard P, Armstrong Scott A, Shih Alan H, Papapetrou Eirini P, Butler Jason M, Cai Sheng F, Bowman Robert L, Levine Ross L
