日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

5'-Guanidino Xylofuranosyl Nucleosides as Novel Types of 5'-Functionalized Nucleosides with Biological Potential

5'-胍基木糖呋喃糖核苷作为具有生物活性的新型5'-功能化核苷

Szilagyi, Jennifer; Moreira, Tânia; Nunes, Rafael Santana; Silva, Joana; Alves, Celso; Martins, Alice; Alvariño, Rebeca; Heise, Niels V; Csuk, René; Xavier, Nuno M

Small Structural Changes in Chili-Derived Capsaicin Resulting in Nonivamide Analogs of Significantly Improved Cytotoxicity and Good Tumor/Non-Tumor Cell Selectivity

辣椒素的微小结构变化可产生具有显著提高的细胞毒性和良好肿瘤/非肿瘤细胞选择性的壬酰胺类似物

Heise, Niels V; Csuk, René; Mueller, Thomas

Advancing Anticancer Drug Discovery: Leveraging Metabolomics and Machine Learning for Mode of Action Prediction by Pattern Recognition

推进抗癌药物发现:利用代谢组学和机器学习进行模式识别以预测作用机制

Saoud, Mohamad; Grau, Jan; Rennert, Robert; Mueller, Thomas; Yousefi, Mohammad; Davari, Mehdi D; Hause, Bettina; Csuk, René; Rashan, Luay; Grosse, Ivo; Tissier, Alain; Wessjohann, Ludger A; Balcke, Gerd U

Combination of Betulinic Acid Fragments and Carbonic Anhydrase Inhibitors-A New Drug Targeting Approach

桦木酸片段与碳酸酐酶抑制剂的组合——一种新的药物靶向方法

Matthias Bache, Niels V Heise, Andreas Thiel, Anne Funtan, Franziska Seifert, Marina Petrenko, Antje Güttler, Sarah Brandt, Thomas Mueller, Dirk Vordermark, Iris Thondorf, René Csuk, Reinhard Paschke

Identification of new pharmacophore against SARS-CoV-2 spike protein by multi-fold computational and biochemical techniques

利用多重计算和生物化学技术鉴定针对SARS-CoV-2刺突蛋白的新药效团

Ullah, Atta; Ullah, Saeed; Halim, Sobia Ahsan; Waqas, Muhammad; Ali, Basharat; Ataya, Farid S; El-Sabbagh, Nasser M; Batiha, Gaber El-Saber; Avula, Satya Kumar; Csuk, Rene; Khan, Ajmal; Al-Harrasi, Ahmed

Advancing Anticancer Drug Discovery: Leveraging Metabolomics and Machine Learning for Mode of Action Prediction by Pattern Recognition (Adv. Sci. 47/2024)

推进抗癌药物发现:利用代谢组学和机器学习进行模式识别以预测作用机制(Adv. Sci. 47/2024)

Vu, Thao; Xu, Yuhang; Qiu, Yumou; Powers, Robert; Saoud, Mohamad; Grau, Jan; Rennert, Robert; Mueller, Thomas; Yousefi, Mohammad; Davari, Mehdi D; Hause, Bettina; Csuk, René; Rashan, Luay; Grosse, Ivo; Tissier, Alain; Wessjohann, Ludger A; Balcke, Gerd U

Mitochondria-Targeting 1,5-Diazacyclooctane-Spacered Triterpene Rhodamine Conjugates Exhibit Cytotoxicity at Sub-Nanomolar Concentration against Breast Cancer Cells

靶向线粒体的 1,5-二氮杂环辛烷间隔三萜罗丹明结合物在亚纳摩尔浓度下对乳腺癌细胞表现出细胞毒性

Niels Heise, Selina Becker, Thomas Mueller, Matthias Bache, René Csuk, Antje Güttler

Discovery of New Boswellic Acid Hybrid 1 H-1,2,3-Triazoles for Diabetic Management: In Vitro and In Silico Studies

发现用于糖尿病管理的新型乳香酸杂合物 1H-1,2,3-三唑:体外和计算机模拟研究

Najeeb Ur Rehman, Saeed Ullah, Tanveer Alam, Sobia Ahsan Halim, Tapan Kumar Mohanta, Ajmal Khan, Muhammad U Anwar, René Csuk, Satya Kumar Avula, Ahmed Al-Harrasi

Structure-Activity Relationship of Anti-Mycobacterium abscessus Piperidine-4-carboxamides, a New Class of NBTI DNA Gyrase Inhibitors

抗脓肿分枝杆菌哌啶-4-甲酰胺类化合物的构效关系,一类新型NBTI DNA促旋酶抑制剂

Beuchel, Andreas; Robaa, Dina; Negatu, Dereje A; Madani, Abdeldjalil; Alvarez, Nadine; Zimmerman, Matthew D; Richter, Adrian; Mann, Lea; Hoenke, Sophie; Csuk, René; Dick, Thomas; Imming, Peter

Comparative study of the cytotoxicity, apoptotic, and epigenetic effects of Boswellic acid derivatives on breast cancer

乳香酸衍生物对乳腺癌的细胞毒性、凋亡和表观遗传效应的比较研究

Jamshidi-Adegani, Fatemeh; Ghaemi, Shokoofeh; Al-Hashmi, Sulaiman; Vakilian, Saeid; Al-Kindi, Juhaina; Rehman, Najeeb Ur; Alam, Khurshid; Al-Riyami, Khamis; Csuk, Rene; Arefian, Ehsan; Al-Harrasi, Ahmed