日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Screening of the Pandemic Response Box Library Identified CRM1/XPO1 as an Anti-Mammarenavirus Druggable Target

对疫情应对库的筛选发现,CRM1/XPO1 是一个可作为抗哺乳动物沙粒病毒药物靶点的基因。

Ofodile, Chukwudi A; Cubitt, Beatrice; Onyemelukwe, Ngozi; Okwuanaso, Chetachi B; Witwit, Haydar; de la Torre, Juan C

Prolonged but finite antigen presentation promotes reversible defects of "helpless" memory CD8(+) T cells.

持续但有限的抗原呈递会促进“无助的”记忆 CD8(+) T 细胞的可逆缺陷

van der Heide Verena, Laghlali Gabriel, Davenport Bennett, Cubitt Beatrice, Roudko Vladimir, Choo Daniel, Jhun Kevin, Humblin Etienne, Vaidya Abishek, Angeliadis Krista, Dawson Travis, Furtado Glaucia, Kamphorst Alice O, Schotsaert Michael, Ahmed Rafi, de la Torre Juan Carlos, Homann Dirk

Repurposing Drugs for Synergistic Combination Therapies to Counteract Monkeypox Virus Tecovirimat Resistance

利用药物再利用协同联合疗法对抗猴痘病毒替科维瑞特耐药性

Witwit, Haydar; Cubitt, Beatrice; Khafaji, Roaa; Castro, Esteban M; Goicoechea, Miguel; Lorenzo, Maria M; Blasco, Rafael; Martinez-Sobrido, Luis; de la Torre, Juan C

Pandemic Response Box Screening Identified CRM1/XPO1 as an Anti-Mammarenavirus Druggable Target

疫情应对筛选确定 CRM1/XPO1 为抗哺乳动物沙粒病毒药物靶点

Ofodile, Chukwudi A; Cubitt, Beatrice; Onyemelukwe, Ngozi; Okwuanaso, Chetachi B; Witwit, Haydar; de la Torre, Juan C

A Lassa virus live attenuated vaccine candidate that is safe and efficacious in guinea pigs

一种对豚鼠安全有效的拉沙病毒减毒活疫苗候选物

Carey, Brian D; Yu, Shuiqing; Geiger, Jillian; Ye, Chengjin; Huzella, Louis M; Reeder, Rebecca J; Mehta, Monika; Hirsch, Shawn; Bernbaum, Rebecca; Cubitt, Beatrice; Pahar, Bapi; Anthony, Scott M; Marketon, Anthony; Bernbaum, John G; Tran, Julie P; Crozier, Ian; Martínez-Sobrido, Luis; Worwa, Gabriella; de la Torre, Juan Carlos; Kuhn, Jens H

Molecular Engineering of a Mammarenavirus with Unbreachable Attenuation

利用分子工程技术构建具有不可突破减毒能力的哺乳动物沙粒病毒

Sakabe, Saori; Cubitt, Beatrice; Martinez-Sobrido, Luis; de la Torre, Juan C

Inhibitors of Anti-apoptotic Bcl-2 Family Proteins Exhibit Potent and Broad-Spectrum Anti-mammarenavirus Activity via Cell Cycle Arrest at G0/G1 Phase

抗凋亡Bcl-2家族蛋白抑制剂通过G0/G1期细胞周期阻滞,表现出强效且广谱的抗哺乳动物沙粒病毒活性。

Kim, Yu-Jin; Witwit, Haydar; Cubitt, Beatrice; de la Torre, Juan C

Lassa Virus Vaccine Candidate ML29 Generates Truncated Viral RNAs Which Contribute to Interfering Activity and Attenuation

拉沙病毒候选疫苗ML29产生截短的病毒RNA,从而导致干扰活性和减毒。

Johnson, Dylan M; Cubitt, Beatrice; Pfeffer, Tia L; de la Torre, Juan Carlos; Lukashevich, Igor S

A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity

一种基于细胞、无感染的平台,用于鉴定拉沙病毒核糖核蛋白(vRNP)活性抑制剂

Cubitt, Beatrice; Ortiz-Riano, Emilio; Cheng, Benson Yh; Kim, Yu-Jin; Yeh, Charles D; Chen, Catherine Z; Southall, N O E; Zheng, Wei; Martinez-Sobrido, Luis; de la Torre, Juan C

Novel Dihydroorotate Dehydrogenase Inhibitors with Potent Interferon-Independent Antiviral Activity against Mammarenaviruses In Vitro

新型二氢乳清酸脱氢酶抑制剂在体外对哺乳动物沙粒病毒具有强效的、不依赖干扰素的抗病毒活性

Kim, Yu-Jin; Cubitt, Beatrice; Cai, Yingyun; Kuhn, Jens H; Vitt, Daniel; Kohlhof, Hella; de la Torre, Juan C