日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Epilepsy-Associated SCN2A-L1342P Mutation Drives Network Hyperexcitability and Widespread Transcriptomic Changes in Human Cortical Organoids

癫痫相关的SCN2A-L1342P突变驱动人类皮质类器官网络过度兴奋和广泛的转录组变化

Olivero-Acosta, Maria I; Robinson, Morgan; Que, Zhefu; Zhang, Zaiyang; Harlow, Hope Elizabeth; Shankar, Vinayak; Hong, Seoyong; Wang, Muhan; Otterbacher, Conrad M; Kadono, Hina; Halurkar, Manasi; Kothandaraman, Harish; Lanman, Nadia; Nguyen, Trang; Wettschurack, Kyle; Zirkle, Benjamin; Yunis, Layan; Cui, Ningren; Chen, Xiaoling; Zhang, Jingliang; Wu, Jiaxiang; Skarnes, William C; Yuan, Chongli; Guo, Feng; Yang, Yang

Human iPSC-derived microglia sense and dampen hyperexcitability of cortical neurons carrying the epilepsy-associated SCN2A-L1342P mutation.

人类 iPSC 衍生的小胶质细胞能够感知并抑制携带癫痫相关 SCN2A-L1342P 突变的皮层神经元的过度兴奋

Que Zhefu, Olivero-Acosta Maria I, Robinson Morgan, Chen Ian, Zhang Jingliang, Wettschurack Kyle, Wu Jiaxiang, Xiao Tiange, Otterbacher C Max, Shankar Vinayak, Harlow Hope, Hong Seoyong, Zirkle Benjamin, Wang Muhan, Cui Ningren, Mandal Purba, Chen Xiaoling, Deming Brody, Halurkar Manasi, Zhao Yuanrui, Rochet Jean-Christophe, Xu Ranjie, Brewster Amy L, Wu Long-Jun, Yuan Chongli, Skarnes William C, Yang Yang

The antitussive cloperastine improves breathing abnormalities in a Rett Syndrome mouse model by blocking presynaptic GIRK channels and enhancing GABA release

镇咳药氯哌斯汀通过阻断突触前GIRK通道并增强GABA释放,改善Rett综合征小鼠模型的呼吸异常。

Johnson, Christopher M; Cui, Ningren; Xing, Hao; Wu, Yang; Jiang, Chun

Mecp2 Disruption in Rats Causes Reshaping in Firing Activity and Patterns of Brainstem Respiratory Neurons

大鼠脑干呼吸神经元的 Mecp2 基因破坏导致其放电活动和模式发生重塑

Wu, Yang; Cui, Ningren; Xing, Hao; Zhong, Weiwei; Arrowood, Colin; Johnson, Christopher M; Jiang, Chun

Effects of early-life exposure to THIP on brainstem neuronal excitability in the Mecp2-null mouse model of Rett syndrome before and after drug withdrawal

早期接触THIP对Rett综合征Mecp2基因敲除小鼠模型脑干神经元兴奋性的影响(停药前后)

Zhong, Weiwei; Johnson, Christopher M; Cui, Ningren; Oginsky, Max F; Wu, Yang; Jiang, Chun

Breathing abnormalities in animal models of Rett syndrome a female neurogenetic disorder

雷特综合征(一种女性神经遗传疾病)动物模型中的呼吸异常

Jiang, Chun; Cui, Ningren; Zhong, Weiwei; Johnson, Christopher M; Wu, Yang

Defects in brainstem neurons associated with breathing and motor function in the Mecp2R168X/Y mouse model of Rett syndrome

在Rett综合征Mecp2R168X/Y小鼠模型中,与呼吸和运动功能相关的脑干神经元存在缺陷

Johnson, Christopher M; Zhong, Weiwei; Cui, Ningren; Wu, Yang; Xing, Hao; Zhang, Shuang; Jiang, Chun

Characterization of Rett Syndrome-like phenotypes in Mecp2-knockout rats

Mecp2基因敲除大鼠Rett综合征样表型的特征分析

Wu, Yang; Zhong, Weiwei; Cui, Ningren; Johnson, Christopher M; Xing, Hao; Zhang, Shuang; Jiang, Chun

Effects of early-life exposure to THIP on phenotype development in a mouse model of Rett syndrome

早期接触THIP对Rett综合征小鼠模型表型发育的影响

Zhong, Weiwei; Johnson, Christopher Mychal; Wu, Yang; Cui, Ningren; Xing, Hao; Zhang, Shuang; Jiang, Chun

Optogenetic intervention to the vascular endothelium.

光遗传学干预血管内皮

Zhang Shuang, Cui Ningren, Wu Yang, Zhong Weiwei, Johnson Christopher M, Jiang Chun