YOD1 mediates isoproterenol-induced cardiac remodeling by deubiquitinating PKM2 and reducing PKM2 tetramerization in cardiomyocytes.
YOD1 通过去泛素化 PKM2 并减少心肌细胞中 PKM2 的四聚化来介导异丙肾上腺素诱导的心脏重塑。
期刊:Acta Pharmacologica Sinica
影响因子:8.4
doi:10.1038/s41401-025-01587-7
Zheng Qing-Song, Xiong Yong-Qiang, Xu Jia-Chen, Qian Jin-Fu, Luo Wu, Wang Qin-Yan, Zhao Yan-Ni, Luo Yue, Cui Ya-Qian, Fang Yi, Guo Xiao-Chen, Chen Ding-Dao, Wang Yi, Liang Guang