O-GlcNAcylation with ubiquitination stabilizes METTL3 to promoting HMGB1 degradation to inhibit ferroptosis and enhance gemcitabine resistance in pancreatic cancer.
O-GlcNAc糖基化与泛素化可稳定METTL3,促进HMGB1降解,从而抑制铁死亡并增强胰腺癌对吉西他滨的耐药性
期刊:Molecular Medicine
影响因子:6.4
doi:10.1186/s10020-025-01285-4
Wang Qiuhong, Wei Dong, Li Chunman, Yang Xiawei, Su Kun, Wang Tao, Zou Renchao, Wang Lianmin, Cun Dongyun, Tang Bo, Wu Tao