日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Plain Language Summary of a Phase 2b Randomized Controlled Trial of Ecopipam and Its 12-Month Open-Label Extension in Children and Adolescents With Tourette Syndrome

一项针对患有图雷特综合征的儿童和青少年的Ecopipam 2b期随机对照试验及其12个月开放标签扩展研究的简明语言摘要

Gilbert, Donald L; Kim, David J B; Miller, Meredith M; Atkinson, Sarah D; Karkanias, George B; Munschauer, Frederick E; Wanaski, Stephen P; Cunniff, Timothy M

G-quadruplexes regulate chromatin accessibility and gene expression in Bloom Syndrome

G-四链体在布鲁姆综合征中调节染色质可及性和基因表达

Su, Dingwen; Altmannova, Veronika; Soltys, Volker; Peters, Moritz; Cunniff, Christopher M; Weir, John R; Chan, Yingguang Frank

KLF5 enables dichotomous lineage programs in pancreatic cancer via the AAA+ ATPase coactivators RUVBL1 and RUVBL2

KLF5 通过 AAA+ ATPase 共激活因子 RUVBL1 和 RUVBL2 激活胰腺癌中的二分谱系程序。

Cunniff, Patrick J; Sivetz, Nicole; Skopelitis, Damianos; Klingbeil, Olaf; Toobian, Daniel; Maia-Silva, Diogo; Egeblad, Mikala; Vakoc, Christopher R

Targeting peroxiredoxin 2 prevents hepatocarcinogenesis in metabolic liver disease models

靶向过氧化物酶2可预防代谢性肝病模型中的肝癌发生

Crouchet, Emilie; Schaeffer, Eugénie; Oudot, Marine A; Moehlin, Julien; Gadenne, Cloé; Jühling, Frank; El Saghire, Hussein; Fujiwara, Naoto; Zhu, Shijia; Akter Rasha, Fahmida; Durand, Sarah C; Charlot, Anouk; Ponsolles, Clara; Martin, Romain; Brignon, Nicolas; Del Zompo, Fabio; Meiss-Heydmann, Laura; Parnot, Marie; Hamdane, Nourdine; Heide, Danijela; Hetzer, Jenny; Heikenwälder, Mathias; Felli, Emanuele; Pessaux, Patrick; Pochet, Nathalie; Zoll, Joffrey; Cunniff, Brian; Hoshida, Yujin; Mailly, Laurent; Baumert, Thomas F; Schuster, Catherine

Mechanism-based peroxiredoxin 3 inhibitors exploit a covalent warhead for cancer therapy

基于机制的过氧化物酶3抑制剂利用共价活性基团进行癌症治疗。

Nelson, Kimberly J; Smalley, Terrence L Jr; Messier, Terri; Gumpena, Rajesh; Gandhi, Uma; Milczarek, Stephanie; Habibovic, Aida; Hoffman, Hattie; Gibson, Victoria; Hondal, Robert J; Lowther, W Todd; Cunniff, Brian

A Physics-Informed Deep Learning Deformable Medical Image Registration Method Based on Neural ODEs

一种基于神经常微分方程的物理信息深度学习可变形医学图像配准方法

Amiri-Hezaveh, Amirhossein; Tan, Shelly; Deng, Qing; Umulis, David; Cunniff, Lauren; Weickenmeier, Johannes; Buganza Tepole, Adrian

Increased frequency of clonal hematopoiesis of indeterminate potential in Bloom syndrome probands and carriers

布鲁姆综合征先证者和携带者中克隆性造血功能异常发生率增加

Lin, Isabella; Wei, Angela; Gebo, Tsumugi A; Boutros, Paul C; Flanagan, Maeve; Kucine, Nicole; Cunniff, Christopher; Arboleda, Valerie A; Chang, Vivian Y

PKM splice-switching ASOs induce upregulation of dual-specificity phosphatases and dephosphorylation of ERK1/2 in hepatocellular carcinoma

PKM剪接转换反义寡核苷酸诱导肝细胞癌中双特异性磷酸酶上调和ERK1/2去磷酸化

Voss, Dillon M; Kral, Alexander J; Sim, GeunYoung; Utama, Raditya; Lin, Kuan-Ting; Cizmeciyan, Chris; Schafer, Balazs; Cunniff, Patrick J; Vakoc, Christopher R; Caruthers, Marvin H; Mishra, Lopa; Krainer, Adrian R

H(2)S remodels mitochondrial ultrastructure and destabilizes respiratory supercomplexes.

H(2)S 重塑线粒体超微结构并破坏呼吸超复合物的稳定性

Hanna David A, Chen Brandon, Shah Yatrik M, Khalimonchuk Oleh, Cunniff Brian, Banerjee Ruma

Miro1 expression alters global gene expression, ERK1/2 phosphorylation, oxidation and cell cycle progression.

Miro1 表达改变整体基因表达、ERK1/2 磷酸化、氧化和细胞周期进程

Shannon Nathaniel, Raymond Cory, Palmer Chloe, Homa Silver, Bonini Marcelo, Seward David, Cunniff Brian