日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A modification to heptad repeat 1 of gp41 improves yield and/or quality of soluble pre-fusion HIV-1 envelope glycoprotein trimers

对 gp41 七肽重复序列 1 的修饰可提高可溶性融合前 HIV-1 包膜糖蛋白三聚体的产量和/或质量。

Chaturbhuj, Devidas N; Sliepen, Kwinten; Cupo, Albert; Steinberg, Benjamin; Kazimierczyk, Simon; Munawar, Tarek; Kramer, Kyle; Yasmeen, Anila; Andrade, Thales G; Lee, Wen-Hsin; van der Maas, Lara; Gibson, Grace; Feliciano, Oscar; Del Moral Sanchez, Ivan; Schermer, Edith; Bronson, Rhianna; Benner, Alison; Prabhakaran, Madhu; Mason, Rosemarie; Klasse, P J; Ward, Andrew B; Ozorowski, Gabriel; Sanders, Rogier W; Moore, John P

HIV-1 envelope trimer vaccine induces sex-associated differences in antibody responses: a phase 1 clinical trial

HIV-1包膜三聚体疫苗诱导抗体反应存在性别差异:一项1期临床试验

Reiss, Emma I M M; van der Straten, Karlijn; Graus, Laura T M; Grobben, Marloes; Vlaming, Kilian E; van der Veen, Annelou I P; Liesdek, Marinus H; Ozorowski, Gabriel; Corcoran, Martin; Gao, Hongmei; Greene, Kelli M; Yates, Nicole L; Sawant, Sheetal; Kerster, Gius; Burger, Judith A; Schonherr, Stella; Cheeseman, Hannah M; Evans, Abbey; McFarlane, Leon R; Tran, Andy S; Torres, Jonathan L; Lin, Ryan N; Jo, Gyunghee; Tolazzi, Monica; Mundsperger, Philipp; Katinger, Dietmar; Cupo, Albert; Moore, John P; Hurks, Rob; Vogt, Liffert; Soeters, Maarten R; Kootstra, Neeltje A; Scarlatti, Gabriella; Tomaras, Georgia D; Montefiori, David C; Karlsson Hedestam, Gunilla B; Ward, Andrew B; Klouwens, Michelle; de Jong, Menno D; Prins, Jan M; Claireaux, Mathieu; Geijtenbeek, Teunis B H; Shattock, Robin J; van Gils, Marit J; Sanders, Rogier W; de Bree, Godelieve J

Germline-targeting HIV Envelope SOSIP immunization more frequently elicits broadly-neutralizing antibody precursor responses in infant compared to juvenile rhesus macaques.

与幼年恒河猴相比,针对生殖系 HIV 包膜 SOSIP 的免疫接种更能频繁地在婴儿中引发广谱中和抗体前体反应

Issah Yasmine A, Hu Xintao, Isaac John, Shen Xiaoying, Davis Dominique, Ozorowski Gabriel, Sewall Leigh M, Zhang Shiyu, Kang Euchong, Vuong Kenneth, Dennis Maria, Chen Jui-Lin, Ramos John M, Yasmeen Anila, Eudailey Joshua, Cupo Albert, Weinbaum Carolyn, Gao Hongmei, Stanfield-Oakley Sherry, Ferrari Guido, Klasse P J, Fouda Genevieve, Hudgens Michael, Ward Andrew B, Montefiori David C, Sanders Rogier W, Moore John P, Van Rompay Koen K A, De Paris Kristina, Permar Sallie R, Nelson Ashley N

Exposure of progressive immune dysfunction by SARS-CoV-2 mRNA vaccination in patients with chronic lymphocytic leukemia: A prospective cohort study

SARS-CoV-2 mRNA疫苗接种导致慢性淋巴细胞白血病患者出现进行性免疫功能障碍:一项前瞻性队列研究

Qin, Kai; Honjo, Kazuhito; Sherrill-Mix, Scott; Liu, Weimin; Stoltz, Regina M; Oman, Allisa K; Hall, Lucinda A; Li, Ran; Sterrett, Sarah; Frederick, Ellen R; Lancaster, Jeffrey R; Narkhede, Mayur; Mehta, Amitkumar; Ogunsile, Foluso J; Patel, Rima B; Ketas, Thomas J; Cruz Portillo, Victor M; Cupo, Albert; Larimer, Benjamin M; Bansal, Anju; Goepfert, Paul A; Hahn, Beatrice H; Davis, Randall S

SARS-CoV-2 mRNA vaccination exposes progressive adaptive immune dysfunction in patients with chronic lymphocytic leukemia

SARS-CoV-2 mRNA疫苗接种暴露了慢性淋巴细胞白血病患者的进行性适应性免疫功能障碍

Qin, Kai; Honjo, Kazuhito; Sherrill-Mix, Scott; Liu, Weimin; Stoltz, Regina; Oman, Allisa K; Hall, Lucinda A; Li, Ran; Sterrett, Sarah; Frederick, Ellen R; Lancaster, Jeffrey R; Narkhede, Mayur; Mehta, Amitkumar; Ogunsile, Foluso J; Patel, Rima B; Ketas, Thomas J; Cruz Portillo, Victor M; Cupo, Albert; Larimer, Benjamin M; Bansal, Anju; Goepfert, Paul A; Hahn, Beatrice H; Davis, Randall S

SOS and IP Modifications Predominantly Affect the Yield but Not Other Properties of SOSIP.664 HIV-1 Env Glycoprotein Trimers

SOS 和 IP 修饰主要影响 SOSIP.664 HIV-1 Env 糖蛋白三聚体的产量,但不影响其其他性质。

Ringe, Rajesh P; Colin, Philippe; Torres, Jonathan L; Yasmeen, Anila; Lee, Wen-Hsin; Cupo, Albert; Ward, Andrew B; Klasse, P J; Moore, John P

Optimizing the production and affinity purification of HIV-1 envelope glycoprotein SOSIP trimers from transiently transfected CHO cells

优化瞬时转染CHO细胞中HIV-1包膜糖蛋白SOSIP三聚体的生产和亲和纯化。

Cupo, Albert; Cruz Portillo, Victor M; Gelfand, Paul; Yasmeen, Anila; Klasse, P J; Moore, John P

Integrity of Glycosylation Processing of a Glycan-Depleted Trimeric HIV-1 Immunogen Targeting Key B-Cell Lineages

糖基化加工的完整性:靶向关键B细胞谱系的糖基缺失三聚体HIV-1免疫原

Behrens, Anna-Janina; Kumar, Abhinav; Medina-Ramirez, Max; Cupo, Albert; Marshall, Kevin; Cruz Portillo, Victor M; Harvey, David J; Ozorowski, Gabriel; Zitzmann, Nicole; Wilson, Ian A; Ward, Andrew B; Struwe, Weston B; Moore, John P; Sanders, Rogier W; Crispin, Max

Open and closed structures reveal allostery and pliability in the HIV-1 envelope spike

HIV-1包膜刺突蛋白的开放和封闭结构揭示了其变构性和可塑性。

Ozorowski, Gabriel; Pallesen, Jesper; de Val, Natalia; Lyumkis, Dmitry; Cottrell, Christopher A; Torres, Jonathan L; Copps, Jeffrey; Stanfield, Robyn L; Cupo, Albert; Pugach, Pavel; Moore, John P; Wilson, Ian A; Ward, Andrew B

Reducing V3 Antigenicity and Immunogenicity on Soluble, Native-Like HIV-1 Env SOSIP Trimers

降低可溶性、天然样 HIV-1 Env SOSIP 三聚体的 V3 抗原性和免疫原性

Ringe, Rajesh P; Ozorowski, Gabriel; Rantalainen, Kimmo; Struwe, Weston B; Matthews, Katie; Torres, Jonathan L; Yasmeen, Anila; Cottrell, Christopher A; Ketas, Thomas J; LaBranche, Celia C; Montefiori, David C; Cupo, Albert; Crispin, Max; Wilson, Ian A; Ward, Andrew B; Sanders, Rogier W; Klasse, P J; Moore, John P