日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Development of VNX-101, an adeno-associated virus with less immunogenicity and efficient long-term expression of a CD19 T cell engager

VNX-101 是一种腺相关病毒,其免疫原性较低,且能有效长期表达 CD19 T 细胞衔接器。

Currier, Mark A; Reha, Allen; Hutzen, Brian; Wang, Pin-Yi; Chen, Chun-Yu; Glaspell, Andrea M; Paudel, Siddhi Nath; Venkataramany, Akila S; Das, Debashree; Hanlon, Danielle; Kaspar, Allan; Varma, Samit; Kaspar, Brian; Morales, Pablo; Ralph, Peter; Johnson, Tonny; Weiss, Tania L; Cripe, Timothy P

Trabectedin promotes oncolytic virus antitumor efficacy, viral gene expression, and immune effector function in models of bone sarcoma.

在骨肉瘤模型中,曲贝替定可促进溶瘤病毒的抗肿瘤功效、病毒基因表达和免疫效应功能

Ringwalt Emily M, Currier Mark A, Glaspell Andrea M, Chen Chun-Yu, Cannon Matthew V, Cam Maren, Gross Amy C, Gust Matthew, Wang Pin-Yi, Boon Louis, Biederman Laura E, Schwarz Emily, Rajappa Prajwal, Lee Dean A, Mardis Elaine R, Carson William E, Roberts Ryan D, Cripe Timothy P

Trabectedin Enhances Oncolytic Virotherapy by Reducing Barriers to Virus Spread and Cytotoxic Immunity in Preclinical Pediatric Bone Sarcoma

曲贝替定通过降低病毒传播屏障和细胞毒性免疫,增强溶瘤病毒疗法在临床前儿童骨肉瘤中的疗效

Ringwalt, Emily M; Currier, Mark A; Glaspell, Andrea M; Chen, Chun-Yu; Cannon, Matthew V; Cam, Maren; Gross, Amy C; Gust, Matthew; Wang, Pin-Yi; Boon, Louis; Biederman, Laura E; Schwarz, Emily; Rajappa, Prajwal; Lee, Dean A; Mardis, Elaine R; Carson, William E; Roberts, Ryan D; Cripe, Timothy P

Opportunities and challenges of combining adoptive cellular therapy with oncolytic virotherapy

将过继细胞疗法与溶瘤病毒疗法相结合的机遇与挑战

Mamola, Joseph A; Chen, Chun-Yu; Currier, Mark A; Cassady, Kevin; Lee, Dean A; Cripe, Timothy P

Intratumoral Injection of HSV1716, an Oncolytic Herpes Virus, Is Safe and Shows Evidence of Immune Response and Viral Replication in Young Cancer Patients

瘤内注射溶瘤性疱疹病毒HSV1716是安全的,并且在年轻癌症患者中显示出免疫反应和病毒复制的证据。

Streby, Keri A; Geller, James I; Currier, Mark A; Warren, Patrick S; Racadio, John M; Towbin, Alexander J; Vaughan, Michele R; Triplet, Melinda; Ott-Napier, Kristy; Dishman, Devon J; Backus, Lori R; Stockman, Beth; Brunner, Marianne; Simpson, Kathleen; Spavin, Robert; Conner, Joe; Cripe, Timothy P

VEGF blockade enables oncolytic cancer virotherapy in part by modulating intratumoral myeloid cells.

VEGF阻断可部分通过调节肿瘤内髓系细胞来实现溶瘤病毒疗法

Currier Mark A, Eshun Francis K, Sholl Allyson, Chernoguz Artur, Crawford Kelly, Divanovic Senad, Boon Louis, Goins William F, Frischer Jason S, Collins Margaret H, Leddon Jennifer L, Baird William H, Haseley Amy, Streby Keri A, Wang Pin-Yi, Hendrickson Brett W, Brekken Rolf A, Kaur Balveen, Hildeman David, Cripe Timothy P

Overexpression of the cellular DEK protein promotes epithelial transformation in vitro and in vivo

细胞DEK蛋白的过表达可促进体外和体内上皮细胞转化。

Wise-Draper, Trisha M; Mintz-Cole, Rachael A; Morris, Teresa A; Simpson, David S; Wikenheiser-Brokamp, Kathryn A; Currier, Mark A; Cripe, Timothy P; Grosveld, Gerard C; Wells, Susanne I

Efficacy and safety of the oncolytic herpes simplex virus rRp450 alone and combined with cyclophosphamide

溶瘤性单纯疱疹病毒rRp450单独使用及与环磷酰胺联合使用的疗效和安全性

Currier, Mark A; Gillespie, Rebecca A; Sawtell, Nancy M; Mahller, Yonatan Y; Stroup, Greg; Collins, Margaret H; Kambara, Hirokazu; Chiocca, E Antonio; Cripe, Timothy P