日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Sequence engineering at non-motif modulator residues yields a peptide that effectively targets a single PDZ protein in a disease-relevant cellular context

对非基序调节残基进行序列工程改造，可得到一种肽，该肽能够有效靶向疾病相关细胞环境中的单个PDZ蛋白。

期刊:
影响因子:
doi:10.1101/2025.09.25.678608
Amacher, Jeanine F; Cushing, Patrick R; Vouilleme, Lars; Cullati, Sierra N; Deng, Bin; Gerber, Scott A; Boisguerin, Prisca; Madden, Dean R
细胞生物学
发表日期：2025
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Correction: Cysteine modification reveals an allosteric inhibitory site on the CAL PDZ domain

更正：半胱氨酸修饰揭示了CAL PDZ结构域上的变构抑制位点。

期刊:Bioscience Reports
影响因子:4.7
doi:10.1042/BSR20180231_COR
Zhao, Yu; Cushing, Patrick R; Smithson, David C; Pellegrini, Maria; Pletnev, Alexandre A; Al-Ayyoubi, Sahar; Grassetti, Andrew V; Gerber, Scott A; Guy, R Kiplin; Madden, Dean R
发表日期：2018
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Cysteine modifiers suggest an allosteric inhibitory site on the CAL PDZ domain

半胱氨酸修饰物提示CAL PDZ结构域上存在变构抑制位点。

期刊:Bioscience Reports
影响因子:4.7
doi:10.1042/BSR20180231
Zhao, Yu; Cushing, Patrick R; Smithson, David C; Pellegrini, Maria; Pletnev, Alexandre A; Al-Ayyoubi, Sahar; Grassetti, Andrew V; Gerber, Scott A; Guy, R Kiplin; Madden, Dean R
发表日期：2018
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Small molecule inhibition of the Na(+)/H(+) exchange regulatory factor 1 and parathyroid hormone 1 receptor interaction

小分子抑制剂对钠/氢交换调节因子1和甲状旁腺激素1受体相互作用的影响

期刊:Biochemistry
影响因子:3
doi:10.1021/bi500368k
Fitzpatrick, Jeremy M; Pellegrini, Maria; Cushing, Patrick R; Mierke, Dale F
信号转导
免疫/内分泌
发表日期：2014
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Stereochemical determinants of C-terminal specificity in PDZ peptide-binding domains: a novel contribution of the carboxylate-binding loop

PDZ肽结合域C端特异性的立体化学决定因素：羧酸盐结合环的新作用

期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1074/jbc.M112.401588
Amacher, Jeanine F; Cushing, Patrick R; Bahl, Christopher D; Beck, Tobias; Madden, Dean R
发表日期：2013
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Hybrid organic-inorganic inhibitors of a PDZ interaction that regulates the endocytic fate of CFTR

调控CFTR内吞命运的PDZ相互作用的有机-无机杂化抑制剂。

期刊:Angewandte Chemie-International Edition
影响因子:16.9
doi:10.1002/anie.201202291
Kundu, Rituparna; Cushing, Patrick R; Popp, Brian V; Zhao, Yu; Madden, Dean R; Ball, Zachary T
信号转导
CFTR
发表日期：2012
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Crystallization and preliminary diffraction analysis of the CAL PDZ domain in complex with a selective peptide inhibitor

CAL PDZ结构域与选择性肽抑制剂复合物的结晶和初步衍射分析

期刊:Acta Crystallographica Section F-Structural Biology and Crystallization Communications
影响因子:1.1
doi:10.1107/S1744309111009985
Amacher, Jeanine F; Cushing, Patrick R; Weiner, Joshua A; Madden, Dean R
发表日期：2011
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A stabilizing influence: CAL PDZ inhibition extends the half-life of ΔF508-CFTR

稳定作用：CAL PDZ 抑制剂延长了 ΔF508-CFTR 的半衰期

期刊:Angewandte Chemie-International Edition
影响因子:16.9
doi:10.1002/anie.201005585
Cushing, Patrick R; Vouilleme, Lars; Pellegrini, Maria; Boisguerin, Prisca; Madden, Dean R
CFTR
发表日期：2010
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Engineering peptide inhibitors to overcome PDZ binding promiscuity

工程改造肽抑制剂以克服PDZ结合的混杂性

期刊:Angewandte Chemie-International Edition
影响因子:16.9
doi:10.1002/anie.201005575
Vouilleme, Lars; Cushing, Patrick R; Volkmer, Rudolf; Madden, Dean R; Boisguerin, Prisca
发表日期：2010
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Disease mutations in RUNX1 and RUNX2 create nonfunctional, dominant-negative, or hypomorphic alleles.

RUNX1 和 RUNX2 中的致病突变会产生无功能、显性负性或功能减弱的等位基因

期刊:EMBO Journal
影响因子:8.3
doi:10.1038/sj.emboj.7601568
Matheny Christina J, Speck Maren E, Cushing Patrick R, Zhou Yunpeng, Corpora Takeshi, Regan Michael, Newman Miki, Roudaia Liya, Speck Caroline L, Gu Ting-Lei, Griffey Stephen M, Bushweller John H, Speck Nancy A
RUNX2
RUNX1
发表日期：2007
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