日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Design, Synthesis, and Investigation of the Pharmacokinetics and Anticancer Activities of Indenoisoquinoline Derivatives That Stabilize the G-Quadruplex in the MYC Promoter and Inhibit Topoisomerase I.

设计、合成和研究稳定 MYC 启动子中 G-四链体并抑制拓扑异构酶 I 的茚并异喹啉衍生物的药代动力学和抗癌活性

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.3c02303
Han Yichen, Buric Adam, Chintareddy Venkat, DeMoss Mercedes, Chen Luying, Dickerhoff Jonathan, De Dios Robyn, Chand Pooran, Riggs Randall, Yang Danzhou, Cushman Mark
肿瘤
肿瘤免疫
发表日期：2024
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Indenoisoquinoline Topoisomerase Inhibitors Strongly Bind and Stabilize the MYC Promoter G-Quadruplex and Downregulate MYC

茚并异喹啉类拓扑异构酶抑制剂能强力结合并稳定MYC启动子G-四链体，从而下调MYC表达。

期刊:Journal of the American Chemical Society
影响因子:15.6
doi:10.1021/jacs.9b02679
Wang, Kai-Bo; Elsayed, Mohamed S A; Wu, Guanhui; Deng, Nanjie; Cushman, Mark; Yang, Danzhou
MYC
发表日期：2019
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Topoisomerase IB poisons induce histone H2A phosphorylation as a response to DNA damage in Leishmania infantum

拓扑异构酶 IB 毒素可诱导利什曼原虫发生组蛋白 H2A 磷酸化，以应对 DNA 损伤。

期刊:International Journal for Parasitology-Drugs and Drug Resistance
影响因子:3.4
doi:10.1016/j.ijpddr.2019.09.005
Gutiérrez-Corbo, Camino; Álvarez-Velilla, Raquel; Reguera, Rosa M; García-Estrada, Carlos; Cushman, Mark; Balaña-Fouce, Rafael; Pérez-Pertejo, Yolanda
信号转导
磷酸化
发表日期：2019
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Antiparasitic effect of synthetic aromathecins on Leishmania infantum

合成芳香化合物对婴儿利什曼原虫的抗寄生虫作用

期刊:BMC Veterinary Research
影响因子:2.6
doi:10.1186/s12917-019-2153-9
Reguera, Rosa M; Álvarez-Velilla, Raquel; Domínguez-Asenjo, Bárbara; Gutiérrez-Corbo, Camino; Balaña-Fouce, Rafael; Cushman, Mark; Pérez-Pertejo, Yolanda
微生物学
发表日期：2019
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Activity of Aromathecins against African Trypanosomes

芳香霉素对非洲锥虫的活性

期刊:Antimicrobial Agents and Chemotherapy
影响因子:4.5
doi:10.1128/AAC.00786-18
Nenortas, Nathaniel P; Cinelli, Maris A; Morrell, Andrew E; Cushman, Mark; Shapiro, Theresa A
发表日期：2018
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Novel clinical indenoisoquinoline topoisomerase I inhibitors: a twist around the camptothecins

新型临床吲哚异喹啉拓扑异构酶I抑制剂：喜树碱类药物的全新选择

期刊:Oncotarget
影响因子:
doi:10.18632/oncotarget.26466
Pommier, Yves; Cushman, Mark; Doroshow, James H
发表日期：2018
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Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci

靶向细胞壁合成的苯基噻唑类抗菌剂在体外和体内均表现出对耐万古霉素肠球菌的强效活性。

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.6b01780
Mohammad, Haroon; Younis, Waleed; Chen, Lu; Peters, Christine E; Pogliano, Joe; Pogliano, Kit; Cooper, Bruce; Zhang, Jianan; Mayhoub, Abdelrahman; Oldfield, Eric; Cushman, Mark; Seleem, Mohamed N
细胞生物学
发表日期：2017
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Synthesis and Biological Evaluation of the First Triple Inhibitors of Human Topoisomerase 1, Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), and Tyrosyl-DNA Phosphodiesterase 2 (Tdp2).

人类拓扑异构酶 1、酪氨酰-DNA 磷酸二酯酶 1 (Tdp1) 和酪氨酰-DNA 磷酸二酯酶 2 (Tdp2) 的首个三重抑制剂的合成和生物学评价

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.6b01565
Wang Ping, Elsayed Mohamed S A, Plescia Caroline B, Ravji Azhar, Redon Christophe E, Kiselev Evgeny, Marchand Christophe, Zeleznik Olga, Agama Keli, Pommier Yves, Cushman Mark
其它
Human
发表日期：2017
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Behavioral deficits and cholinergic pathway abnormalities in male Sanfilippo B mice

雄性 Sanfilippo B 小鼠的行为缺陷和胆碱能通路异常

期刊:Behavioural Brain Research
影响因子:2.6
doi:10.1016/j.bbr.2016.06.023
Shih-Hsin Kan, Steven Q Le, Quang D Bui, Braeden Benedict, Jesse Cushman, Mark S Sands, Patricia I Dickson
其它
发表日期：2016
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Anti-biofilm activity and synergism of novel thiazole compounds with glycopeptide antibiotics against multidrug-resistant staphylococci

新型噻唑类化合物与糖肽类抗生素对多重耐药葡萄球菌的抗生物膜活性及协同作用

期刊:Journal of Antibiotics
影响因子:2.7
doi:10.1038/ja.2014.142
Mohammad, Haroon; Mayhoub, Abdelrahman S; Cushman, Mark; Seleem, Mohamed N
微生物学
发表日期：2015
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