日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Type I Hsp40s/DnaJs aggregates exhibit features reminiscent of amyloidogenic structures

型 Hsp40s/DnaJs 聚集体表现出类似于淀粉样蛋白结构的特征

Tiroli-Cepeda, Ana O; Linhares, Leonardo A; Aragão, Annelize Z B; de Jesus, Jemmyson R; Wasilewska-Sampaio, Ana P; De Felice, Fernanda G; Ferreira, Sérgio T; Borges, Júlio C; Cyr, Douglas M; Ramos, Carlos H I

J-domain protein chaperone circuits in proteostasis and disease

J结构域蛋白分子伴侣回路在蛋白质稳态和疾病中的作用

Zhang, Ruobing; Malinverni, Duccio; Cyr, Douglas M; Rios, Paolo De Los; Nillegoda, Nadinath B

DNAJB12 and Hsp70 Mediate Triage of Misfolded Membrane Proteins for Proteasomal versus Lysosomal Degradation

DNAJB12和Hsp70介导错误折叠的膜蛋白的分类,决定其是被蛋白酶体降解还是被溶酶体降解。

Kennedy, Andrew; Cyr, Douglas M

From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations

从CFTR生物学到联合药物治疗:囊性纤维化突变的扩展分类

Veit, Gudio; Avramescu, Radu G; Chiang, Annette N; Houck, Scott A; Cai, Zhiwei; Peters, Kathryn W; Hong, Jeong S; Pollard, Harvey B; Guggino, William B; Balch, William E; Skach, William R; Cutting, Garry R; Frizzell, Raymond A; Sheppard, David N; Cyr, Douglas M; Sorscher, Eric J; Brodsky, Jeffrey L; Lukacs, Gergely L

Quality control autophagy degrades soluble ERAD-resistant conformers of the misfolded membrane protein GnRHR

自噬质量控制机制会降解错误折叠的膜蛋白GnRHR的可溶性ERAD抗性构象体。

Houck, Scott A; Ren, Hong Yu; Madden, Victoria J; Bonner, Jacob N; Conlin, Michael P; Janovick, Jo Ann; Conn, P Michael; Cyr, Douglas M

Polyglutamine-rich suppressors of huntingtin toxicity act upstream of Hsp70 and Sti1 in spatial quality control of amyloid-like proteins

富含多聚谷氨酰胺的亨廷顿蛋白毒性抑制因子在淀粉样蛋白样蛋白的空间质量控制中,位于Hsp70和Sti1的上游。

Wolfe, Katie J; Ren, Hong Yu; Trepte, Philipp; Cyr, Douglas M

VX-809 corrects folding defects in cystic fibrosis transmembrane conductance regulator protein through action on membrane-spanning domain 1

VX-809 通过作用于跨膜结构域 1 来纠正囊性纤维化跨膜传导调节蛋白的折叠缺陷

Ren, Hong Yu; Grove, Diane E; De La Rosa, Oxana; Houck, Scott A; Sopha, Pattarawut; Van Goor, Fredrick; Hoffman, Beth J; Cyr, Douglas M

Mechanisms for quality control of misfolded transmembrane proteins

错误折叠跨膜蛋白的质量控制机制

Houck, Scott A; Cyr, Douglas M

Cellular responses to misfolded proteins and protein aggregates

细胞对错误折叠蛋白和蛋白聚集体的反应

Houck, Scott A; Singh, Sangita; Cyr, Douglas M

Amyloid in neurodegenerative diseases: friend or foe?

神经退行性疾病中的淀粉样蛋白:是敌是友?

Wolfe, Katie J; Cyr, Douglas M