日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Substrate adaptors are flexible tethering modules that enhance substrate methylation by the arginine methyltransferase PRMT5

底物适配器是灵活的连接模块,可增强精氨酸甲基转移酶PRMT5对底物的甲基化作用。

Jin, Cyrus Y; Hunkeler, Moritz; Mulvaney, Kathleen M; Sellers, William R; Fischer, Eric S

Template-assisted covalent modification underlies activity of covalent molecular glues

模板辅助共价修饰是共价分子胶活性的基础

Yen-Der Li #, Michelle W Ma #, Muhammad Murtaza Hassan #, Moritz Hunkeler, Mingxing Teng, Kedar Puvar, Justine C Rutter, Ryan J Lumpkin, Brittany Sandoval, Cyrus Y Jin, Anna M Schmoker, Scott B Ficarro, Hakyung Cheong, Rebecca J Metivier, Michelle Y Wang, Shawn Xu, Woong Sub Byun, Brian J Groendyke,

Exploration of the tunability of BRD4 degradation by DCAF16 trans-labelling covalent glues

利用DCAF16反式标记共价胶探索BRD4降解的可调控性

Hassan, Muhammad Murtaza; Li, Yen-Der; Ma, Michelle W; Teng, Mingxing; Byun, Woong Sub; Puvar, Kedar; Lumpkin, Ryan; Sandoval, Brittany; Rutter, Justine C; Jin, Cyrus Y; Wang, Michelle Y; Xu, Shawn; Schmoker, Anna M; Cheong, Hakyung; Groendyke, Brian J; Qi, Jun; Fischer, Eric S; Ebert, Benjamin L; Gray, Nathanael S

Structures of BIRC6-client complexes provide a mechanism of SMAC-mediated release of caspases

BIRC6-客户端复合物的结构提供了 SMAC 介导的 caspase 释放机制

Moritz Hunkeler, Cyrus Y Jin, Eric S Fischer

HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways

HAPSTR1 将 HUWE1 定位到细胞核中以限制应激信号通路

Julie K Monda, Xuezhen Ge, Moritz Hunkeler, Katherine A Donovan, Michelle W Ma, Cyrus Y Jin, Marilyn Leonard, Eric S Fischer, Eric J Bennett

Exploration of the Tunability of BRD4 Degradation by DCAF16 Trans-labelling Covalent Glues

利用 DCAF16 反式标记共价胶探索 BRD4 降解的可调控性

Hassan, Muhammad Murtaza; Li, Yen-Der; Ma, Michelle W; Teng, Mingxing; Byun, Woong Sub; Puvar, Kedar; Lumpkin, Ryan; Sandoval, Brittany; Rutter, Justine C; Jin, Cyrus Y; Wang, Michelle Y; Xu, Shawn; Schmoker, Anna M; Cheong, Hakyung; Groendyke, Brian J; Qi, Jun; Fischer, Eric S; Ebert, Benjamin L; Gray, Nathanael S

Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders

模板辅助共价修饰 DCAF16 是 BRD4 分子胶降解剂活性的基础

Yen-Der Li, Michelle W Ma, Muhammad Murtaza Hassan, Moritz Hunkeler, Mingxing Teng, Kedar Puvar, Ryan Lumpkin, Brittany Sandoval, Cyrus Y Jin, Scott B Ficarro, Michelle Y Wang, Shawn Xu, Brian J Groendyke, Logan H Sigua, Isidoro Tavares, Charles Zou, Jonathan M Tsai, Paul M C Park, Hojong Yoon, Feli

Impact of hospital readiness on patient safety incidents during the COVID-19 pandemic in Indonesia: health worker perceptions

医院准备情况对印尼新冠疫情期间患者安全事件的影响:医护人员的看法

Dhamanti, Inge; Indriani, Diah; Miftahussurur, Muhammad; Kurniawati, Eva; Engineer, Cyrus Y

Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition

HUWE1 的螺线管结构有助于连接酶活性和底物识别

Moritz Hunkeler, Cyrus Y Jin, Michelle W Ma, Julie K Monda, Daan Overwijn, Eric J Bennett, Eric S Fischer

Identifying core competencies for practicing public health professionals: results from a Delphi exercise in Uttar Pradesh, India

确定公共卫生专业人员的核心能力:印度北方邦德尔菲法调查的结果

Bhandari, Sudip; Wahl, Brian; Bennett, Sara; Engineer, Cyrus Y; Pandey, Pooja; Peters, David H