日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Cardiorenal Outcomes With Tirzepatide Compared With Dulaglutide in Patients With Diabetes and Cardiovascular Disease: A Post Hoc Analysis of the SURPASS-CVOT Randomized Clinical Trial

在糖尿病合并心血管疾病患者中,替拉帕肽与度拉糖肽的心肾结局比较:SURPASS-CVOT随机临床试验的事后分析

Nissen, Steven E; Wolski, Kathy; D'Alessio, David; Weerakkody, Govinda; Kiljanski, Jacek; Wiese, Russell J; Pavo, Imre; Cariou, Bertrand; Nicholls, Stephen J

Ectopic, hepatic GLP-1R agonism enhances the weight loss efficacy of GLP-1 analogues

异位肝脏GLP-1R激动作用可增强GLP-1类似物的减肥效果。

Douros, Jonathan D; Capozzi, Megan; Novikoff, Aaron; Mokrosinski, Jacek; DuBois, Barent; Stock, Joseph; Rohlfs, Rebecca; Anderson, Mikayla; Jedrzejcyk, Dominika J; Poulsen, Svend; Blenke, Erik Oude; Dago, Tomas; Huus, Kasper; Nørby, Peder L; Kobberup, Sune; Rivir, Marita; Sorrell, Joyce; Mowery, Stephanie A; Drucker, Daniel J; D'Alessio, David A; Campbell, Jonathan E; Müller, Timo D; Perez-Tilve, Diego; Finan, Brian; Knerr, Patrick J

β Cell Gαs signaling is critical for physiological and pharmacological enhancement of insulin secretion

β细胞Gαs信号传导对于生理和药理学上增强胰岛素分泌至关重要。

Capozzi, Megan E; Bouslov, David; Sargsyan, Ashot; Chan, Michelle Y; Chen, Alex; Gray, Sarah M; Viloria, Katrina; Bareja, Akshay; Douros, Jonathan D; Lewandowski, Sophie L; Tong, Jason Cl; Hasib, Annie; Cuozzo, Federica; Ross, Elizabeth C; Foster, Matthew W; Weinstein, Lee S; Hussain, Mehboob A; Merrins, Matthew J; Willard, Francis S; Huising, Mark O; Sloop, Kyle W; Hodson, David J; D'Alessio, David A; Campbell, Jonathan E

α cells use both PC1/3 and PC2 to process proglucagon peptides and control insulin secretion

α细胞利用PC1/3和PC2来加工胰高血糖素原肽并控制胰岛素分泌。

Cui, Canqi; Leander, Danielle C; Gray, Sarah M; El, Kimberley; Chen, Alex; Grimsrud, Paul A; Becker, Jessica O; Taylor, Austin; Zhang, Guo-Fang; Sloop, Kyle W; Verchere, C Bruce; Hoofnagle, Andrew N; D'Alessio, David A; Campbell, Jonathan E

Glucose-dependent insulinotropic polypeptide (GIP)

葡萄糖依赖性促胰岛素多肽(GIP)

Müller, Timo D; Adriaenssens, Alice; Ahrén, Bo; Blüher, Matthias; Birkenfeld, Andreas L; Campbell, Jonathan E; Coghlan, Matthew P; D'Alessio, David; Deacon, Carolyn F; DelPrato, Stefano; Douros, Jonathan D; Drucker, Daniel J; Figueredo Burgos, Natalie S; Flatt, Peter R; Finan, Brian; Gimeno, Ruth E; Gribble, Fiona M; Hayes, Matthew R; Hölscher, Christian; Holst, Jens J; Knerr, Patrick J; Knop, Filip K; Kusminski, Christine M; Liskiewicz, Arkadiusz; Mabilleau, Guillaume; Mowery, Stephanie A; Nauck, Michael A; Novikoff, Aaron; Reimann, Frank; Roberts, Anna G; Rosenkilde, Mette M; Samms, Ricardo J; Scherer, Philip E; Seeley, Randy J; Sloop, Kyle W; Wolfrum, Christian; Wootten, Denise; DiMarchi, Richard D; Tschöp, Matthias H

Reduction of prevalence of patients meeting the criteria for metabolic syndrome with tirzepatide: a post hoc analysis from the SURPASS Clinical Trial Program

使用替拉帕肽降低符合代谢综合征标准的患者患病率:SURPASS 临床试验项目的一项事后分析

Nicholls, Stephen J; Tofé, Santiago; le Roux, Carel W; D'Alessio, David A; Wiese, Russell J; Pavo, Imre; Brown, Katelyn; Weerakkody, Govinda J; Zeytinoglu, Meltem; Romera, Irene C

High Doses of Exogenous Glucagon Stimulate Insulin Secretion and Reduce Insulin Clearance in Healthy Humans

高剂量外源性胰高血糖素可刺激健康人体内胰岛素分泌并降低胰岛素清除率。

Gray, Sarah M; Goonatilleke, Elisha; Emrick, Michelle A; Becker, Jessica O; Hoofnagle, Andrew N; Stefanovski, Darko; He, Wentao; Zhang, Guofang; Tong, Jenny; Campbell, Jonathan; D'Alessio, David A

GIPR/GLP-1R dual agonist therapies for diabetes and weight loss-chemistry, physiology, and clinical applications

用于糖尿病和减肥的GIPR/GLP-1R双重激动剂疗法——化学、生理学和临床应用

Campbell, Jonathan E; Müller, Timo D; Finan, Brian; DiMarchi, Richard D; Tschöp, Matthias H; D'Alessio, David A

Assessment of the incretin effect in healthy subjects: concordance between clamp and OGTT methods

健康受试者肠促胰岛素效应的评估:钳夹试验与口服葡萄糖耐量试验的一致性

Aulinger, Benedikt A; D'Alessio, David A

The Impact of Pregnancy on Diabetic Retinopathy: A Single-Site Study of Clinical Risk Factors

妊娠对糖尿病视网膜病变的影响:一项单中心临床危险因素研究

Rathinavelu, Jay; Sarvepalli, Swara M; Bailey, Beth; D'Alessio, David; Hadziahmetovic, Majda