Nicotine-Inspired, De Novo-Designed SARS-CoV-2 Main Protease Inhibitors Reveal Unique Chemistry for Covalently Conjugating Both Cysteine and Histidine Residues in the Catalytic Dyad
受尼古丁启发,全新设计的SARS-CoV-2主蛋白酶抑制剂揭示了催化二元体中半胱氨酸和组氨酸残基共价连接的独特化学机制。
期刊:Journal of the American Chemical Society
影响因子:15.6
doi:10.1021/jacs.6c01119
Atla, Sandeep; Vulupala, Veerabhadra; Alugubelli, Yugendar R; Blankenship, Lauren R; Yang, Kai; Nyalata, Satyanarayana; Khatua, Kaustav; Coleman, Demonta; Rabie, Dorsa; Guo, Xuejiao; Cho, Chia-Chuan D; Kumar, Sathish; Le, Lai Hoang Son; Sankaran, Banumathi; Kalugin, Justin K; Sharma, Shivangi; Neuman, Benjamin W; Xu, Shiqing; Liu, Wenshe Ray