日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

TLR8 agonist selgantolimod regulates Kupffer cell differentiation status and impairs HBV entry into hepatocytes via an IL-6-dependent mechanism

TLR8激动剂selgantolimod通过IL-6依赖性机制调节库普弗细胞分化状态并抑制HBV进入肝细胞。

Roca Suarez, Armando Andres; Plissonnier, Marie-Laure; Grand, Xavier; Michelet, Maud; Giraud, Guillaume; Saez-Palma, Maria; Dubois, Anaëlle; Heintz, Sarah; Diederichs, Audrey; Van Renne, Nicolaas; Vanwolleghem, Thomas; Daffis, Stephane; Li, Li; Kolhatkar, Nikita; Hsu, Yao-Chun; Wallin, Jeffrey J; Lau, Audrey H; Fletcher, Simon P; Rivoire, Michel; Levrero, Massimo; Testoni, Barbara; Zoulim, Fabien

Immunotherapeutic Strategies as Potential Treatment Options for Cutaneous Leishmaniasis

免疫治疗策略作为皮肤利什曼病的潜在治疗选择

Lafleur, Andrea; Daffis, Stephane; Mowbray, Charles; Arana, Byron

Phenotypic CD8 T cell profiling in chronic hepatitis B to predict HBV-specific CD8 T cell susceptibility to functional restoration in vitro

慢性乙型肝炎中CD8 T细胞表型分析预测HBV特异性CD8 T细胞体外功能恢复的敏感性

Rossi, Marzia; Vecchi, Andrea; Tiezzi, Camilla; Barili, Valeria; Fisicaro, Paola; Penna, Amalia; Montali, Ilaria; Daffis, Stephane; Fletcher, Simon P; Gaggar, Anuj; Medley, Jonathan; Graupe, Michael; Lad, Latesh; Loglio, Alessandro; Soffredini, Roberta; Borghi, Marta; Pollicino, Teresa; Musolino, Cristina; Alfieri, Arianna; Brillo, Federica; Laccabue, Diletta; Massari, Marco; Boarini, Chiara; Abbati, Gianluca; Pedrazzi, Giuseppe; Missale, Gabriele; Lampertico, Pietro; Ferrari, Carlo; Boni, Carolina

Toll-Like Receptor 8 Agonist GS-9688 Induces Sustained Efficacy in the Woodchuck Model of Chronic Hepatitis B

Toll样受体8激动剂GS-9688在土拨鼠慢性乙型肝炎模型中诱导持续疗效

Daffis, Stephane; Balsitis, Scott; Chamberlain, Jason; Zheng, Jim; Santos, Rex; Rowe, William; Ramakrishnan, Dhivya; Pattabiraman, Divya; Spurlock, Sandra; Chu, Ruth; Kang, Don; Mish, Michael; Ramirez, Ricardo; Li, Li; Li, Bei; Ma, Sarina; Hung, Magdeleine; Voitenleitner, Christian; Yon, Changsuek; Suresh, Manasa; Menne, Stephan; Cote, Paul; Delaney, William E 4th; Mackman, Richard; Fletcher, Simon P

Therapeutic Potential of TLR8 Agonist GS-9688 (Selgantolimod) in Chronic Hepatitis B: Remodeling of Antiviral and Regulatory Mediators

TLR8 激动剂 GS-9688(Selgantolimod)在慢性乙型肝炎中的治疗潜力:抗病毒和调节介质的重塑

Oliver E Amin, Emily J Colbeck, Stephane Daffis, Shahzada Khan, Dhivya Ramakrishnan, Divya Pattabiraman, Ruth Chu, Holly Micolochick Steuer, Sophie Lehar, Leanne Peiser, Adam Palazzo, Christian Frey, Jessica Davies, Hassan Javanbakht, William M C Rosenberg, Simon P Fletcher, Mala K Maini, Laura J Pa

Anti-HBV response to toll-like receptor 7 agonist GS-9620 is associated with intrahepatic aggregates of T cells and B cells

抗HBV反应与Toll样受体7激动剂GS-9620诱导的肝内T细胞和B细胞聚集有关。

Li, Li; Barry, Vivian; Daffis, Stephane; Niu, Congrong; Huntzicker, Erik; French, Dorothy M; Mikaelian, Igor; Lanford, Robert E; Delaney, William E 4th; Fletcher, Simon P

Direct antiviral properties of TLR ligands against HBV replication in immune-competent hepatocytes

TLR 配体对免疫功能正常的肝细胞中 HBV 复制的直接抗病毒特性

Julie Lucifora, Marc Bonnin, Ludovic Aillot, Floriane Fusil, Sarah Maadadi, Laura Dimier, Maud Michelet, Océane Floriot, Anaïs Ollivier, Michel Rivoire, Malika Ait-Goughoulte, Stéphane Daffis, Simon P Fletcher, Anna Salvetti, François-Loïc Cosset, Fabien Zoulim, David Durantel

The Smc5/6 Complex Restricts HBV when Localized to ND10 without Inducing an Innate Immune Response and Is Counteracted by the HBV X Protein Shortly after Infection.

Smc5/6 复合物在 ND10 处定位时可限制 HBV,而不会诱发先天免疫反应,并且在感染后不久就会被 HBV X 蛋白抵消

Niu Congrong, Livingston Christine M, Li Li, Beran Rudolf K, Daffis Stephane, Ramakrishnan Dhivya, Burdette Dara, Peiser Leanne, Salas Eduardo, Ramos Hilario, Yu Mei, Cheng Guofeng, Strubin Michel, Delaney William E IV, Fletcher Simon P

Sustained efficacy and seroconversion with the Toll-like receptor 7 agonist GS-9620 in the Woodchuck model of chronic hepatitis B

在土拨鼠慢性乙型肝炎模型中,Toll样受体7激动剂GS-9620表现出持续疗效和血清转化作用。

Menne, Stephan; Tumas, Daniel B; Liu, Katherine H; Thampi, Linta; AlDeghaither, Dalal; Baldwin, Betty H; Bellezza, Christine A; Cote, Paul J; Zheng, Jim; Halcomb, Randall; Fosdick, Abigail; Fletcher, Simon P; Daffis, Stephane; Li, Li; Yue, Peng; Wolfgang, Grushenka H I; Tennant, Bud C

West Nile virus noncoding subgenomic RNA contributes to viral evasion of the type I interferon-mediated antiviral response.

西尼罗河病毒非编码亚基因组RNA有助于病毒逃避I型干扰素介导的抗病毒反应

Schuessler Andrea, Funk Anneke, Lazear Helen M, Cooper Daphne A, Torres Shessy, Daffis Stephane, Jha Babal Kant, Kumagai Yutaro, Takeuchi Osamu, Hertzog Paul, Silverman Robert, Akira Shizuo, Barton David J, Diamond Michael S, Khromykh Alexander A