日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

TLR8 agonist selgantolimod regulates Kupffer cell differentiation status and impairs HBV entry into hepatocytes via an IL-6-dependent mechanism

TLR8激动剂selgantolimod通过IL-6依赖性机制调节库普弗细胞分化状态并抑制HBV进入肝细胞。

Roca Suarez, Armando Andres; Plissonnier, Marie-Laure; Grand, Xavier; Michelet, Maud; Giraud, Guillaume; Saez-Palma, Maria; Dubois, Anaëlle; Heintz, Sarah; Diederichs, Audrey; Van Renne, Nicolaas; Vanwolleghem, Thomas; Daffis, Stephane; Li, Li; Kolhatkar, Nikita; Hsu, Yao-Chun; Wallin, Jeffrey J; Lau, Audrey H; Fletcher, Simon P; Rivoire, Michel; Levrero, Massimo; Testoni, Barbara; Zoulim, Fabien

Immunotherapeutic Strategies as Potential Treatment Options for Cutaneous Leishmaniasis

免疫治疗策略作为皮肤利什曼病的潜在治疗选择

Lafleur, Andrea; Daffis, Stephane; Mowbray, Charles; Arana, Byron

Phenotypic CD8 T cell profiling in chronic hepatitis B to predict HBV-specific CD8 T cell susceptibility to functional restoration in vitro

慢性乙型肝炎中CD8 T细胞表型分析预测HBV特异性CD8 T细胞体外功能恢复的敏感性

Rossi, Marzia; Vecchi, Andrea; Tiezzi, Camilla; Barili, Valeria; Fisicaro, Paola; Penna, Amalia; Montali, Ilaria; Daffis, Stephane; Fletcher, Simon P; Gaggar, Anuj; Medley, Jonathan; Graupe, Michael; Lad, Latesh; Loglio, Alessandro; Soffredini, Roberta; Borghi, Marta; Pollicino, Teresa; Musolino, Cristina; Alfieri, Arianna; Brillo, Federica; Laccabue, Diletta; Massari, Marco; Boarini, Chiara; Abbati, Gianluca; Pedrazzi, Giuseppe; Missale, Gabriele; Lampertico, Pietro; Ferrari, Carlo; Boni, Carolina

Toll-Like Receptor 8 Agonist GS-9688 Induces Sustained Efficacy in the Woodchuck Model of Chronic Hepatitis B

Toll样受体8激动剂GS-9688在土拨鼠慢性乙型肝炎模型中诱导持续疗效

Daffis, Stephane; Balsitis, Scott; Chamberlain, Jason; Zheng, Jim; Santos, Rex; Rowe, William; Ramakrishnan, Dhivya; Pattabiraman, Divya; Spurlock, Sandra; Chu, Ruth; Kang, Don; Mish, Michael; Ramirez, Ricardo; Li, Li; Li, Bei; Ma, Sarina; Hung, Magdeleine; Voitenleitner, Christian; Yon, Changsuek; Suresh, Manasa; Menne, Stephan; Cote, Paul; Delaney, William E 4th; Mackman, Richard; Fletcher, Simon P

Anti-HBV response to toll-like receptor 7 agonist GS-9620 is associated with intrahepatic aggregates of T cells and B cells

抗HBV反应与Toll样受体7激动剂GS-9620诱导的肝内T细胞和B细胞聚集有关。

Li, Li; Barry, Vivian; Daffis, Stephane; Niu, Congrong; Huntzicker, Erik; French, Dorothy M; Mikaelian, Igor; Lanford, Robert E; Delaney, William E 4th; Fletcher, Simon P

The Smc5/6 Complex Restricts HBV when Localized to ND10 without Inducing an Innate Immune Response and Is Counteracted by the HBV X Protein Shortly after Infection.

Smc5/6 复合物在 ND10 处定位时可限制 HBV,而不会诱发先天免疫反应,并且在感染后不久就会被 HBV X 蛋白抵消

Niu Congrong, Livingston Christine M, Li Li, Beran Rudolf K, Daffis Stephane, Ramakrishnan Dhivya, Burdette Dara, Peiser Leanne, Salas Eduardo, Ramos Hilario, Yu Mei, Cheng Guofeng, Strubin Michel, Delaney William E IV, Fletcher Simon P

Sustained efficacy and seroconversion with the Toll-like receptor 7 agonist GS-9620 in the Woodchuck model of chronic hepatitis B

在土拨鼠慢性乙型肝炎模型中,Toll样受体7激动剂GS-9620表现出持续疗效和血清转化作用。

Menne, Stephan; Tumas, Daniel B; Liu, Katherine H; Thampi, Linta; AlDeghaither, Dalal; Baldwin, Betty H; Bellezza, Christine A; Cote, Paul J; Zheng, Jim; Halcomb, Randall; Fosdick, Abigail; Fletcher, Simon P; Daffis, Stephane; Li, Li; Yue, Peng; Wolfgang, Grushenka H I; Tennant, Bud C

West Nile virus noncoding subgenomic RNA contributes to viral evasion of the type I interferon-mediated antiviral response.

西尼罗河病毒非编码亚基因组RNA有助于病毒逃避I型干扰素介导的抗病毒反应

Schuessler Andrea, Funk Anneke, Lazear Helen M, Cooper Daphne A, Torres Shessy, Daffis Stephane, Jha Babal Kant, Kumagai Yutaro, Takeuchi Osamu, Hertzog Paul, Silverman Robert, Akira Shizuo, Barton David J, Diamond Michael S, Khromykh Alexander A

Interferon regulatory factor-1 (IRF-1) shapes both innate and CD8(+) T cell immune responses against West Nile virus infection.

干扰素调节因子-1 (IRF-1) 可影响先天性和 CD8(+) T 细胞对西尼罗河病毒感染的免疫反应

Brien James D, Daffis Stephane, Lazear Helen M, Cho Hyelim, Suthar Mehul S, Gale Michael Jr, Diamond Michael S

2'-O methylation of the viral mRNA cap evades host restriction by IFIT family members

病毒mRNA帽的2'-O甲基化可逃避IFIT家族成员对宿主的限制

Daffis, Stephane; Szretter, Kristy J; Schriewer, Jill; Li, Jianqing; Youn, Soonjeon; Errett, John; Lin, Tsai-Yu; Schneller, Stewart; Zust, Roland; Dong, Hongping; Thiel, Volker; Sen, Ganes C; Fensterl, Volker; Klimstra, William B; Pierson, Theodore C; Buller, R Mark; Gale, Michael Jr; Shi, Pei-Yong; Diamond, Michael S