日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Knock-in mice expressing a humanized arachidonic acid 15-lipoxygenase (Alox15) carry a partly dysfunctional erythropoietic system

表达人源化花生四烯酸 15-脂氧合酶 (Alox15) 的敲入小鼠携带部分功能障碍的红细胞生成系统

Florian Reisch, Dagmar Heydeck, Marjann Schäfer, Michael Rothe, Jiaxing Yang, Sabine Stehling, Gerhard P Püschel, Hartmut Kuhn

Transgenic mice overexpressing human ALOX15 under the control of the aP2 promoter are partly protected in the complete Freund's adjuvant-induced paw inflammation model

在 aP2 启动子的控制下,过量表达人类 ALOX15 的转基因小鼠在完全弗氏佐剂诱发的爪炎症模型中受到部分保护

Dagmar Heydeck, Kumar R Kakularam, Dominika Labuz, Halina Machelska, Nadine Rohwer, Karsten Weylandt, Hartmut Kuhn

Bony Fish Arachidonic Acid 15-Lipoxygenases Exhibit Different Catalytic Properties than Their Mammalian Orthologs, Suggesting Functional Enzyme Evolution during Vertebrate Development

硬骨鱼花生四烯酸 15-脂氧合酶表现出与其哺乳动物直系同源物不同的催化特性,表明功能性酶在脊椎动物发育过程中进化

Sophie Roigas, Kumar R Kakularam, Michael Rothe, Dagmar Heydeck, Polamarasetty Aparoy, Hartmut Kuhn

Humanization of the Reaction Specificity of Mouse Alox15b Inversely Modified the Susceptibility of Corresponding Knock-In Mice in Two Different Animal Inflammation Models

小鼠 Alox15b 反应特异性的人源化反向改变了相应基因敲入小鼠在两种不同动物炎症模型中的易感性

Marjann Schäfer, Florian Reisch, Dominika Labuz, Halina Machelska, Sabine Stehling, Gerhard P Püschel, Michael Rothe, Dagmar Heydeck, Hartmut Kuhn

Male guanine-rich RNA sequence binding factor 1 knockout mice (Grsf1-/-) gain less body weight during adolescence and adulthood

雄性富含鸟嘌呤 RNA 序列结合因子 1 基因敲除小鼠(Grsf1-/-)在青春期和成年期体重增加较少

Bernhard Dumoulin, Dagmar Heydeck, Desiree Jähn, Moritz Lassé, Sajad Sofi, Christoph Ufer, Hartmut Kuhn

The Reaction Specificity of Mammalian ALOX15 Orthologs is Changed During Late Primate Evolution and These Alterations Might Offer Evolutionary Advantages for Hominidae

哺乳动物 ALOX15 直系同源物的反应特异性在灵长类动物晚期进化过程中发生了变化,这些改变可能为人科动物提供进化优势

Dagmar Heydeck, Florian Reisch, Marjann Schäfer, Kumar R Kakularam, Sophie A Roigas, Sabine Stehling, Gerhard P Püschel, Hartmut Kuhn

Male Knock-in Mice Expressing an Arachidonic Acid Lipoxygenase 15B (Alox15B) with Humanized Reaction Specificity Are Prematurely Growth Arrested When Aging

表达具有人源化反应特异性的花生四烯酸脂氧合酶 15B (Alox15B) 的雄性基因敲入小鼠在衰老过程中会过早停止生长

Marjann Schäfer, Kumar R Kakularam, Florian Reisch, Michael Rothe, Sabine Stehling, Dagmar Heydeck, Gerhard P Püschel, Hartmut Kuhn

Functional Characterization of Novel Bony Fish Lipoxygenase Isoforms and Their Possible Involvement in Inflammation

新型硬骨鱼脂氧合酶亚型的功能表征及其在炎症中可能的作用

Sophie Roigas, Dagmar Heydeck, Hartmut Kuhn

Knock-In Mice Expressing a 15-Lipoxygenating Alox5 Mutant Respond Differently to Experimental Inflammation Than Reported Alox5-/- Mice

表达 15-脂氧合 Alox5 突变体的基因敲入小鼠对实验性炎症的反应与已报道的 Alox5-/- 小鼠不同

Eugenia Marbach-Breitrück, Nadine Rohwer, Carmen Infante-Duarte, Silvina Romero-Suarez, Dominika Labuz, Halina Machelska, Laura Kutzner, Nils Helge Schebb, Michael Rothe, Pallu Reddanna, Karsten H Weylandt, Lothar H Wieler, Dagmar Heydeck, Hartmut Kuhn

Functional characterization of a novel arachidonic acid 12S-lipoxygenase in the halotolerant bacterium Myxococcus fulvus exhibiting complex social living patterns

具有复杂社会生活模式的耐盐细菌粘球菌中新型花生四烯酸 12S-脂氧合酶的功能表征

Kateryna Goloshchapova, Sabine Stehling, Dagmar Heydeck, Maximilian Blum, Hartmut Kuhn