日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

TYK2 regulates tau levels, phosphorylation and aggregation in a tauopathy mouse model

TYK2 在 tau 蛋白病小鼠模型中调节 tau 蛋白水平、磷酸化和聚集。

Jiyoen Kim ,Bakhos Tadros ,Yan Hong Liang ,Youngdoo Kim ,Cristian Lasagna-Reeves ,Jun Young Sonn ,Dah-Eun Chloe Chung ,Bradley Hyman ,David M Holtzman ,Huda Yahya Zoghbi

The big tau splice isoform resists Alzheimer's-related pathological changes

大tau蛋白剪接异构体能够抵抗阿尔茨海默病相关的病理变化。

Chung, Dah-Eun Chloe; Deng, Xue; Yalamanchili, Hari K; Revelli, Jean-Pierre; Han, Alexander L; Tadros, Bakhos; Richman, Ronald; Dias, Michelle; Naini, Fatemeh Alavi; Boeynaems, Steven; Hyman, Bradley T; Zoghbi, Huda Y

Neuronal ApoE upregulates MHC-I expression to drive selective neurodegeneration in Alzheimer's disease

神经元 ApoE 上调 MHC-I 表达,从而驱动阿尔茨海默病中的选择性神经变性

Kelly A Zalocusky, Ramsey Najm, Alice L Taubes, Yanxia Hao, Seo Yeon Yoon, Nicole Koutsodendris, Maxine R Nelson, Antara Rao, David A Bennett, Jason Bant, Dah-Eun J Amornkul, Qin Xu, Alice An, Olga Cisne-Thomson, Yadong Huang

Cellular and pathological heterogeneity of primary tauopathies

原发性tau蛋白病的细胞和病理异质性

Chung, Dah-Eun Chloe; Roemer, Shanu; Petrucelli, Leonard; Dickson, Dennis W

Enhanced phosphorylation of T153 in soluble tau is a defining biochemical feature of the A152T tau risk variant

可溶性 tau 中 T153 的磷酸化增强是 A152T tau 风险变异的一个决定性生化特征

Yari Carlomagno, Dah-Eun Chloe Chung, Mei Yue, Aishe Kurti, Nicole M Avendano, Monica Castanedes-Casey, Kelly M Hinkle, Karen Jansen-West, Lillian M Daughrity, Jimei Tong, Virginia Phillips, Rosa Rademakers, Michael DeTure, John D Fryer, Dennis W Dickson, Leonard Petrucelli, Casey Cook

Tau exhibits unique seeding properties in globular glial tauopathy

Tau蛋白在球状胶质细胞tau蛋白病中表现出独特的播散特性。

Chung, Dah-Eun Chloe; Carlomagno, Yari; Cook, Casey N; Jansen-West, Karen; Daughrity, Lillian; Lewis-Tuffin, Laura J; Castanedes-Casey, Monica; DeTure, Michael; Dickson, Dennis W; Petrucelli, Leonard

Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector

小分子结构校正剂可改善人类 iPSC 衍生神经元中毒性载脂蛋白 E4 效应的增强

Chengzhong Wang, Ramsey Najm, Qin Xu, Dah-Eun Jeong, David Walker, Maureen E Balestra, Seo Yeon Yoon, Heidi Yuan, Gang Li, Zachary A Miller, Bruce L Miller, Mary J Malloy, Yadong Huang

An acetylation-phosphorylation switch that regulates tau aggregation propensity and function

调节 tau 聚集倾向和功能的乙酰化-磷酸化开关

Yari Carlomagno, Dah-Eun Chloe Chung, Mei Yue, Monica Castanedes-Casey, Benjamin J Madden, Judy Dunmore, Jimei Tong, Michael DeTure, Dennis W Dickson, Leonard Petrucelli, Casey Cook

miR-186 is decreased in aged brain and suppresses BACE1 expression

miR-186 在老年大脑中减少并抑制 BACE1 表达

Jaekwang Kim, Hyejin Yoon, Dah-Eun Chung, Jennifer L Brown, Krystal C Belmonte, Jungsu Kim

Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors

小分子结构矫正剂可以挽救细胞内载脂蛋白E4转运的结构依赖性障碍及其有害影响。

Brodbeck, Jens; McGuire, Jim; Liu, Zhaoping; Meyer-Franke, Anke; Balestra, Maureen E; Jeong, Dah-eun; Pleiss, Mike; McComas, Casey; Hess, Fred; Witter, David; Peterson, Scott; Childers, Matthew; Goulet, Mark; Liverton, Nigel; Hargreaves, Richard; Freedman, Stephen; Weisgraber, Karl H; Mahley, Robert W; Huang, Yadong