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Subthreshold activation of the melanocortin system causes generalized sensitization to anorectic agents in mice

黑皮质素系统的阈下激活会导致小鼠对厌食剂产生普遍的敏感性。

Dahir, Naima S; Gui, Yijun; Wu, Yanan; Sweeney, Patrick R; Rouault, Alix Aj; Williams, Savannah Y; Gimenez, Luis E; Sawyer, Tomi K; Joy, Stephen T; Mapp, Anna K; Cone, Roger D

发表日期：2024

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Structure of the Ion Channel Kir7.1 and Implications for its Function in Normal and Pathophysiologic States

Kir7.1离子通道的结构及其在正常和病理生理状态下的功能意义

期刊:

影响因子:

doi:10.1101/2024.06.07.597981

Peisley, Alys; Hernandez, Ciria C; Dahir, Naima S; Koepping, Laura; Raczkowski, Ashleigh; Su, Min; Ghamari-Langroudi, Masoud; Ji, Xinrui; Gimenez, Luis E; Cone, Roger D

发表日期：2024

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Melanocortin-3 receptor expression in AgRP neurons is required for normal activation of the neurons in response to energy deficiency.

在能量缺乏的情况下，AgRP 神经元中黑皮质素-3 受体的表达是神经元正常激活所必需的

期刊:Cell Reports

影响因子:6.9

doi:10.1016/j.celrep.2023.113188

Gui Yijun, Dahir Naima S, Wu Yanan, Downing Griffin, Sweeney Patrick, Cone Roger D

神经科学

发表日期：2023

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The unique structural characteristics of the Kir 7.1 inward rectifier potassium channel: a novel player in energy homeostasis control

Kir 7.1 内向整流钾通道独特的结构特征：能量稳态调控中的新角色

期刊:American Journal of Physiology-Cell Physiology

影响因子:4.7

doi:10.1152/ajpcell.00335.2022

Hernandez, Ciria C; Gimenez, Luis E; Dahir, Naima S; Peisley, Alys; Cone, Roger D

信号转导

发表日期：2023

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Inhibition of the melanocortin-3 receptor (MC3R) causes generalized sensitization to anorectic agents

黑皮质素-3受体（MC3R）的抑制会导致对厌食剂的普遍敏感性增加。

期刊:

影响因子:

doi:10.1101/2023.12.05.570114

Dahir, Naima S; Gui, Yijun; Wu, Yanan; Sweeney, Patrick R; Williams, Savannah Y; Gimenez, Luis E; Sawyer, Tomi K; Joy, Stephen T; Mapp, Anna K; Cone, Roger D

信号转导

发表日期：2023

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Sex differences in fat taste responsiveness are modulated by estradiol

雌二醇调节脂肪味觉反应的性别差异

期刊:American Journal of Physiology-Endocrinology and Metabolism

影响因子:3.1

doi:10.1152/ajpendo.00331.2020

Dahir, Naima S; Calder, Ashley N; McKinley, Blake J; Liu, Yan; Gilbertson, Timothy A

发表日期：2021

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Estrogen-Dependent Variation in the Contributions of TRPM4 and TRPM5 to Fat Taste

雌激素依赖性TRPM4和TRPM5对脂肪味觉贡献的变化

An improved synthesis of Compound 11, a unique bicyclic melanocortin-3 antagonist

化合物 11 的改进合成，化合物 11 是一种独特的双环黑皮质素-3 拮抗剂

Estrogen Dependent Variation in the Contributions of TRPM4 and TRPM5 to Fat Taste

雌激素依赖性TRPM4和TRPM5对脂肪味觉贡献的变化

Subthreshold activation of the melanocortin system causes generalized sensitization to anorectic agents in mice

黑皮质素系统的阈下激活会导致小鼠对厌食剂产生普遍的敏感性。

Structure of the Ion Channel Kir7.1 and Implications for its Function in Normal and Pathophysiologic States

Kir7.1离子通道的结构及其在正常和病理生理状态下的功能意义

Melanocortin-3 receptor expression in AgRP neurons is required for normal activation of the neurons in response to energy deficiency.

在能量缺乏的情况下，AgRP 神经元中黑皮质素-3 受体的表达是神经元正常激活所必需的

The unique structural characteristics of the Kir 7.1 inward rectifier potassium channel: a novel player in energy homeostasis control

Kir 7.1 内向整流钾通道独特的结构特征：能量稳态调控中的新角色

Inhibition of the melanocortin-3 receptor (MC3R) causes generalized sensitization to anorectic agents

黑皮质素-3受体（MC3R）的抑制会导致对厌食剂的普遍敏感性增加。

Sex differences in fat taste responsiveness are modulated by estradiol

雌二醇调节脂肪味觉反应的性别差异