日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Positive allosteric modulator of SERCA pump NDC-1171 attenuates cardiac functional decline in mouse model of Duchenne muscular dystrophy

SERCA泵的正向变构调节剂NDC-1171可减轻杜氏肌营养不良症小鼠模型的心脏功能衰退

Narra, Niharika; Richards, Alyssa M; Earl, Conner C; Cox, Abigail D; Dahl, Russell; Koss, Wendy A; Goergen, Craig J

A Positive Allosteric Modulator of the SERCA Pump Rescues Hippocampal Neuronal Circuits Dysfunction and Cognitive Defects in a Mouse Model of Alzheimer's Disease.

SERCA泵的正向变构调节剂可挽救阿尔茨海默病小鼠模型的海马神经回路功能障碍和认知缺陷

Gerasimov Evgenii, Rakovskaya Anastasiya, Pchitskaya Ekaterina, Vlasova Olga, Dahl Russell, Bezprozvanny Ilya

Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor

发现 5-((5-氯-2-甲氧基苯基)磺酰胺基)烟酰胺 (SBI-425),一种强效且口服生物利用度高的组织非特异性碱性磷酸酶 (TNAP) 抑制剂

Pinkerton, Anthony B; Sergienko, Eduard; Bravo, Yalda; Dahl, Russell; Ma, Chen-Ting; Sun, Qing; Jackson, Michael R; Cosford, Nicholas D P; Millán, José Luis

Identification of a selective inhibitor of murine intestinal alkaline phosphatase (ML260) by concurrent ultra-high throughput screening against human and mouse isozymes

通过同时对人和小鼠同工酶进行超高通量筛选,鉴定出一种小鼠肠道碱性磷酸酶选择性抑制剂(ML260)。

Ardecky, Robert J; Bobkova, Ekaterina V; Kiffer-Moreira, Tina; Brown, Brock; Ganji, Santhi; Zou, Jiwen; Pass, Ian; Narisawa, Sonoko; Iano, Flávia Godoy; Rosenstein, Craig; Cheltsov, Anton; Rascon, Justin; Hedrick, Michael; Gasior, Carlton; Forster, Anita; Shi, Shenghua; Dahl, Russell; Vasile, Stefan; Su, Ying; Sergienko, Eduard; Chung, Thomas D Y; Kaunitz, Jonathan; Hoylaerts, Marc F; Pinkerton, Anthony B; Millán, José Luis

Design, synthesis and evaluation of benzoisothiazolones as selective inhibitors of PHOSPHO1

设计、合成和评价苯并异噻唑酮类化合物作为PHOSPHO1选择性抑制剂

Bravo, Yalda; Teriete, Peter; Dhanya, Raveendra-Panickar; Dahl, Russell; Lee, Pooi San; Kiffer-Moreira, Tina; Ganji, Santhi Reddy; Sergienko, Eduard; Smith, Layton H; Farquharson, Colin; Millán, José Luis; Cosford, Nicholas D P

Endoplasmic reticulum protein BI-1 regulates Ca²⁺-mediated bioenergetics to promote autophagy

内质网蛋白BI-1通过调节Ca²⁺介导的生物能量学来促进自噬

Sano, Renata; Hou, Ying-Chen Claire; Hedvat, Michael; Correa, Ricardo G; Shu, Chih-Wen; Krajewska, Maryla; Diaz, Paul W; Tamble, Craig M; Quarato, Giovanni; Gottlieb, Roberta A; Yamaguchi, Masaya; Nizet, Victor; Dahl, Russell; Thomas, David D; Tait, Stephen W; Green, Douglas R; Fisher, Paul B; Matsuzawa, Shu-Ichi; Reed, John C

A gatekeeper residue for NEDD8-activating enzyme inhibition by MLN4924.

MLN4924 抑制 NEDD8 激活酶的门控残基

Toth Julia I, Yang Li, Dahl Russell, Petroski Matthew D

Phosphomannose isomerase inhibitors improve N-glycosylation in selected phosphomannomutase-deficient fibroblasts

磷酸甘露糖异构酶抑制剂可改善特定磷酸甘露糖变位酶缺陷型成纤维细胞的N-糖基化作用

Sharma, Vandana; Ichikawa, Mie; He, Ping; Scott, David A; Bravo, Yalda; Dahl, Russell; Ng, Bobby G; Cosford, Nicholas D P; Freeze, Hudson H

Design, synthesis, and structure-activity relationship studies of thiophene-3-carboxamide derivatives as dual inhibitors of the c-Jun N-terminal kinase.

噻吩-3-甲酰胺衍生物作为c-Jun N端激酶双重抑制剂的设计、合成及构效关系研究

De Surya K, Barile Elisa, Chen Vida, Stebbins John L, Cellitti Jason F, Machleidt Thomas, Carlson Coby B, Yang Li, Dahl Russell, Pellecchia Maurizio

Design and NMR studies of cyclic peptides targeting the N-terminal domain of the protein tyrosine phosphatase YopH

针对蛋白酪氨酸磷酸酶 YopH 的 N 端结构域的环状肽的设计和核磁共振研究

Leone, Marilisa; Barile, Elisa; Dahl, Russell; Pellecchia, Maurizio