Heterogeneity-induced NGF-NGFR communication inefficiency promotes mitotic spindle disorganization in exhausted T cells through PREX1 suppression to impair the anti-tumor immunotherapy with PD-1 mAb in hepatocellular carcinoma
异质性诱导的NGF-NGFR通讯效率低下通过抑制PREX1促进耗竭T细胞有丝分裂纺锤体紊乱，从而削弱PD-1单克隆抗体在肝细胞癌中的抗肿瘤免疫治疗效果。
期刊:Cancer Medicine
影响因子:3.1
doi:10.1002/cam4.6736
Wang, Xin; Yang, Tongwang; Shi, Shangheng; Xu, Chuanshen; Wang, Feng; Dai, Deshu; Guan, Ge; Zhang, Yong; Wang, Shuxian; Wang, Jianhong; Zhang, Bingliang; Liu, Peng; Bai, Xiaoshuai; Jin, Yan; Li, Xinqiang; Zhu, Cunle; Chen, Dexi; Xu, Qingguo; Guo, Yuan
单克隆抗体
肿瘤
T细胞
肿瘤免疫
NGFR
PD-1
T细胞
细胞生物学
NGF
免疫/内分泌
