MFG-E8 alleviates intervertebral disc degeneration by suppressing pyroptosis and extracellular matrix degradation in nucleus pulposus cells via Nrf2/TXNIP/NLRP3 axis
MFG-E8通过Nrf2/TXNIP/NLRP3轴抑制髓核细胞的细胞焦亡和细胞外基质降解,从而缓解椎间盘退变。
期刊:Cell Death Discovery
影响因子:7
doi:10.1038/s41420-022-01002-8
Ma, Haiwei; Xie, Chenglong; Chen, Zhengtai; He, Gaolu; Dai, Zihan; Cai, Hanchen; Zhang, Haojie; Lu, Hongwei; Wu, Hongqiang; Hu, Xinli; Zhou, Kailiang; Zheng, Gang; Xu, Huazi; Xu, Cong
表观遗传
TXNIP
LRP3
焦亡
NLRP3
细胞生物学