日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Multivalency Enables Signal Processing at Single Protein Level

多价性使得单蛋白水平的信号处理成为可能

Wu, Xiaoyu; Jia, Yuanqi; Zhang, Tong; Xiong, Zhehao; Ye, Zihang; Yu, Ge; Lei, Yingjie; Mao, Zhuo; Qu, Vicky; Dang, Bobo; Xu, Ziyao; Chen, Zibo

Identification of SARS-CoV-2 PLpro and 3CLpro human proteome substrates using substrate phage display coupled with protein network analysis.

利用底物噬菌体展示结合蛋白质网络分析鉴定SARS-CoV-2 PLpro和3CLpro人类蛋白质组底物

Zhao Kai, Li Yini, Guo Mengzhun, Ma Lijia, Dang Bobo

Novel Engineered SARS-CoV-2 HR1 Trimer Exhibits Improved Potency and Broad-Spectrum Activity against SARS-CoV-2 and Its Variants

新型工程化SARS-CoV-2 HR1三聚体对SARS-CoV-2及其变种表现出更高的效力和广谱活性

Bi, Wenwen; Chen, Guilin; Dang, Bobo

Engineered trimeric ACE2 binds viral spike protein and locks it in "Three-up" conformation to potently inhibit SARS-CoV-2 infection

经基因工程改造的三聚体ACE2可结合病毒刺突蛋白并将其锁定在“三聚体”构象,从而有效抑制SARS-CoV-2感染。

Guo, Liang; Bi, Wenwen; Wang, Xinling; Xu, Wei; Yan, Renhong; Zhang, Yuanyuan; Zhao, Kai; Li, Yaning; Zhang, Mingfeng; Cai, Xia; Jiang, Shibo; Xie, Youhua; Zhou, Qiang; Lu, Lu; Dang, Bobo

A disease-associated mutation in fibrillin-1 differentially regulates integrin-mediated cell adhesion

纤维蛋白-1中的一种疾病相关突变会差异性地调节整合素介导的细胞黏附。

Del Cid, Joselyn S; Reed, Nilgun Isik; Molnar, Kathleen; Liu, Sean; Dang, Bobo; Jensen, Sacha A; DeGrado, William; Handford, Penny A; Sheppard, Dean; Sundaram, Aparna B

Inversion of the Side-Chain Stereochemistry of Indvidual Thr or Ile Residues in a Protein Molecule: Impact on the Folding, Stability, and Structure of the ShK Toxin

蛋白质分子中单个苏氨酸或异亮氨酸残基侧链立体化学构型的反转:对ShK毒素的折叠、稳定性和结构的影响

Dang, Bobo; Shen, Rong; Kubota, Tomoya; Mandal, Kalyaneswar; Bezanilla, Francisco; Roux, Benoit; Kent, Stephen B H

De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures

从头设计具有独特三级结构的共价约束介观尺寸蛋白支架。

Dang, Bobo; Wu, Haifan; Mulligan, Vikram Khipple; Mravic, Marco; Wu, Yibing; Lemmin, Thomas; Ford, Alexander; Silva, Daniel-Adriano; Baker, David; DeGrado, William F

Elucidation of the Covalent and Tertiary Structures of Biologically Active Ts3 Toxin

阐明具有生物活性的Ts3毒素的共价结构和三级结构

Dang, Bobo; Kubota, Tomoya; Mandal, Kalyaneswar; Correa, Ana M; Bezanilla, Francisco; Kent, Stephen B H

Total chemical synthesis of biologically active fluorescent dye-labeled Ts1 toxin

生物活性荧光染料标记的Ts1毒素的全化学合成

Dang, Bobo; Kubota, Tomoya; Correa, Ana M; Bezanilla, Francisco; Kent, Stephen B H