Stromal cells engineered to express T cell factors induce robust CLL cell proliferation in vitro and in PDX co-transplantations allowing the identification of RAF inhibitors as anti-proliferative drugs
经过基因改造以表达 T 细胞因子的基质细胞可在体外和 PDX 联合移植中诱导强劲的 CLL 细胞增殖，从而可将 RAF 抑制剂鉴定为抗增殖药物
期刊:Leukemia
影响因子:12.8
doi:10.1038/s41375-024-02284-w
Eva Hoferkova, Vaclav Seda, Sona Kadakova, Jan Verner, Tomas Loja, Kvetoslava Matulova, Hana Skuhrova Francova, Eva Ondrouskova, Daniel Filip, Nicolas Blavet, Miroslav Boudny, Gabriela Mladonicka Pavlasova, Josef Vecera, Laura Ondrisova, Petra Pavelkova, Krystof Hlavac, Lenka Kostalova, Androniki Mi
