日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Human tNeurons reveal aging-linked proteostasis deficits driving Alzheimer's phenotypes

人类 tNeurons 揭示与衰老相关的蛋白质稳态缺陷,导致阿尔茨海默病表型

Ching-Chieh Chou, Ryan Vest, Miguel A Prado, Joshua Wilson-Grady, Joao A Paulo, Yohei Shibuya, Patricia Moran-Losada, Ting-Ting Lee, Jian Luo, Steven P Gygi, Jeffery W Kelly, Daniel Finley, Marius Wernig, Tony Wyss-Coray, Judith Frydman

Rational design of proteasome inhibitors based on the structure of the endogenous inhibitor PI31/Fub1

根据内源性抑制剂 PI31/Fub1 的结构合理设计蛋白酶体抑制剂

Benjamin Velez, Aida Razi, Robert D Hubbard, Richard Walsh, Shaun Rawson, Geng Tian, Daniel Finley, John Hanna

USP14-regulated allostery of the human proteasome by time-resolved cryo-EM

通过时间分辨低温电子显微镜观察 USP14 调控的人类蛋白酶体变构

Shuwen Zhang #, Shitao Zou #, Deyao Yin, Lihong Zhao, Daniel Finley, Zhaolong Wu, Youdong Mao

Liver RBFOX2 regulates cholesterol homeostasis via Scarb1 alternative splicing in mice

肝脏 RBFOX2 通过小鼠 Scarb1 可变剪接调节胆固醇稳态

Helen A B Paterson #, Sijia Yu #, Natalia Artigas, Miguel A Prado, Nejc Haberman, Yi-Fang Wang, Andrew M Jobbins, Elena Pahita, Joao Mokochinski, Zoe Hall, Maryse Guerin, Joao A Paulo, Soon Seng Ng, Francesc Villarroya, Sheikh Tamir Rashid, Wilfried Le Goff, Boris Lenhard, Inês Cebola, Daniel Finley

Using Bayesian inference to estimate plausible muscle forces in musculoskeletal models

利用贝叶斯推断估计肌肉骨骼模型中合理的肌肉力量

Johnson, Russell T; Lakeland, Daniel; Finley, James M

Membrane skeleton modulates erythroid proteome remodeling and organelle clearance

膜骨架调节红细胞蛋白质组重塑和细胞器清除

Yijie Liu, Yang Mei, Xu Han, Farida V Korobova, Miguel A Prado, Jing Yang, Zhangli Peng, Joao A Paulo, Steven P Gygi, Daniel Finley, Peng Ji

Global proteomics of Ubqln2-based murine models of ALS

基于 Ubqln2 的 ALS 小鼠模型的整体蛋白质组学

Alexandra M Whiteley, Miguel A Prado, Stefanie A H de Poot, Joao A Paulo, Marissa Ashton, Sara Dominguez, Martin Weber, Hai Ngu, John Szpyt, Mark P Jedrychowski, Amy Easton, Steven P Gygi, Thimo Kurz, Mervyn J Monteiro, Eric J Brown, Daniel Finley

ALS/FTD mutations in UBQLN2 are linked to mitochondrial dysfunction through loss-of-function in mitochondrial protein import

UBQLN2 中的 ALS/FTD 突变与线粒体功能障碍有关,因为线粒体蛋白质导入功能丧失

Brian C Lin, Trong H Phung, Nicole R Higgins, Jessie E Greenslade, Miguel A Prado, Daniel Finley, Mariusz Karbowski, Brian M Polster, Mervyn J Monteiro

Chromatin accessibility promotes hematopoietic and leukemia stem cell activity

染色质可及性促进造血干细胞和白血病干细胞的活性

Lucia Cabal-Hierro ,Peter van Galen ,Miguel A Prado ,Kelly J Higby ,Katsuhiro Togami ,Cody T Mowery ,Joao A Paulo ,Yingtian Xie ,Paloma Cejas ,Takashi Furusawa ,Michael Bustin ,Henry W Long ,David B Sykes ,Steven P Gygi ,Daniel Finley ,Bradley E Bernstein ,Andrew A Lane

The proteasome 19S cap and its ubiquitin receptors provide a versatile recognition platform for substrates

蛋白酶体 19S 帽及其泛素受体为底物提供了多功能识别平台

Kirby Martinez-Fonts, Caroline Davis, Takuya Tomita, Suzanne Elsasser, Andrew R Nager, Yuan Shi, Daniel Finley, Andreas Matouschek