日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Co-transcriptional modifications of 2'-hydroxyls on synthetic mRNA enhance ribonuclease resistance and lipid nanoparticle thermostability

合成mRNA上2'-羟基的共转录修饰可增强核糖核酸酶抗性和脂质纳米颗粒的热稳定性。

Kohki Yamada ,Yun-Chieh Sung ,Tsung-Ying Lee ,Daniel J Siegwart

Bone-marrow-homing lipid nanoparticles for genome editing in diseased and malignant haematopoietic stem cells

用于病变和恶性造血干细胞基因组编辑的骨髓靶向脂质纳米颗粒

Xizhen Lian ,Sumanta Chatterjee ,Yehui Sun ,Sean A Dilliard ,Stephen Moore ,Yufen Xiao ,Xiaoyan Bian ,Kohki Yamada ,Yun-Chieh Sung ,Rachel M Levine ,Kalin Mayberry ,Samuel John ,Xiaoye Liu ,Caroline Smith ,Lindsay T Johnson ,Xu Wang ,Cheng Cheng Zhang ,David R Liu ,Gregory A Newby ,Mitchell J Weiss ,Jonathan S Yen ,Daniel J Siegwart

Expanding RNAi to Kidneys, Lungs, and Spleen via Selective ORgan Targeting (SORT) siRNA Lipid Nanoparticles

通过选择性器官靶向(SORT)siRNA脂质纳米颗粒将RNAi扩展到肾脏、肺和脾脏

Amogh Vaidya ,Stephen Moore ,Sumanta Chatterjee ,Erick Guerrero ,Minjeong Kim ,Lukas Farbiak ,Sean A Dilliard ,Daniel J Siegwart

Lung SORT LNPs enable precise homology-directed repair mediated CRISPR/Cas genome correction in cystic fibrosis models

肺部 SORT LNP 可在囊性纤维化模型中实现精确的同源定向修复介导的 CRISPR/Cas 基因组校正

Tuo Wei # ,Yehui Sun # ,Qiang Cheng # ,Sumanta Chatterjee ,Zachary Traylor ,Lindsay T Johnson ,Melissa L Coquelin ,Jialu Wang ,Michael J Torres ,Xizhen Lian ,Xu Wang ,Yufen Xiao ,Craig A Hodges ,Daniel J Siegwart

Lung SORT LNPs enable precise homology-directed repair mediated CRISPR/Cas genome correction in cystic fibrosis models

肺部 SORT LNP 可在囊性纤维化模型中实现精确的同源定向修复介导的 CRISPR/Cas 基因组校正

Tuo Wei # ,Yehui Sun # ,Qiang Cheng # ,Sumanta Chatterjee ,Zachary Traylor,Lindsay T Johnson ,Melissa L Coquelin,Jialu Wang,Michael J Torres,Xizhen Lian ,Xu Wang ,Yufen Xiao ,Craig A Hodges,Daniel J Siegwart

Preparation of selective organ-targeting (SORT) lipid nanoparticles (LNPs) using multiple technical methods for tissue-specific mRNA delivery

使用多种技术方法制备选择性器官靶向 (SORT) 脂质纳米粒子 (LNP) 以实现组织特异性 mRNA 递送

Xu Wang, Shuai Liu, Yehui Sun, Xueliang Yu, Sang M Lee, Qiang Cheng, Tuo Wei, Junyu Gong, Joshua Robinson, Di Zhang, Xizhen Lian, Pratima Basak, Daniel J Siegwart

In vivo screening identifies SPP2, a secreted factor that negatively regulates liver regeneration

体内筛选鉴定出 SPP2,一种负向调节肝再生的分泌因子

Yu-Hsuan Lin, Qiyu Zeng, Yuemeng Jia, Zixi Wang, Lin Li, Meng-Hsiung Hsieh, Qiang Cheng, Chase A Pagani, Nicholas Livingston, Jeon Lee, Yu Zhang, Tripti Sharma, Daniel J Siegwart, Dean Yimlamai, Benjamin Levi, Hao Zhu

The interplay of quaternary ammonium lipid structure and protein corona on lung-specific mRNA delivery by selective organ targeting (SORT) nanoparticles

季铵脂质结构与蛋白质冠层之间的相互作用对选择性器官靶向 (SORT) 纳米粒子肺特异性 mRNA 递送的影响

Sean A Dilliard, Yehui Sun, Madeline O Brown, Yun-Chieh Sung, Sumanta Chatterjee, Lukas Farbiak, Amogh Vaidya, Xizhen Lian, Xu Wang, Andrew Lemoff, Daniel J Siegwart

In situ production and secretion of proteins endow therapeutic benefit against psoriasiform dermatitis and melanoma

蛋白质的原位产生和分泌赋予对银屑病样皮炎和黑色素瘤的治疗益处

Qiang Cheng #, Lukas Farbiak #, Amogh Vaidya, Erick Guerrero, Eunice E Lee, Elysha K Rose, Xu Wang, Joshua Robinson, Sang M Lee, Tuo Wei, William E Miller, Ester Alvarez Benedicto, Xizhen Lian, Richard C Wang, Daniel J Siegwart

In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration

体内 CRISPR 筛选发现 BAZ2 染色质重塑因子是哺乳动物肝脏再生过程中可作为药物靶点的调控因子。

Yuemeng Jia ,Lin Li ,Yu-Hsuan Lin ,Purva Gopal ,Shunli Shen ,Kejin Zhou ,Xueliang Yu ,Tripti Sharma ,Yu Zhang ,Daniel J Siegwart ,Joseph M Ready ,Hao Zhu