日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer

发现对皮肤癌具有治疗作用的强效选择性 MRCK 抑制剂

Mathieu Unbekandt, Simone Belshaw, Justin Bower, Maeve Clarke, Jacqueline Cordes, Diane Crighton, Daniel R Croft, Martin J Drysdale, Mathew J Garnett, Kathryn Gill, Christopher Gray, David A Greenhalgh, James A M Hall, Jennifer Konczal, Sergio Lilla, Duncan McArthur, Patricia McConnell, Laura McDona

LIM kinase inhibitors disrupt mitotic microtubule organization and impair tumor cell proliferation

LIM 激酶抑制剂破坏有丝分裂微管组织并损害肿瘤细胞增殖

Katerina Mardilovich, Mark Baugh, Diane Crighton, Dominika Kowalczyk, Mads Gabrielsen, June Munro, Daniel R Croft, Filipe Lourenco, Daniel James, Gabriella Kalna, Lynn McGarry, Oliver Rath, Emma Shanks, Mathew J Garnett, Ultan McDermott, Joanna Brookfield, Mark Charles, Tim Hammonds, Michael F Olson

Loss of autophagy causes a synthetic lethal deficiency in DNA repair

自噬丧失导致 DNA 修复发生合成致死缺陷

Emma Y Liu, Naihan Xu, Jim O'Prey, Laurence Y Lao, Sanket Joshi, Jaclyn S Long, Margaret O'Prey, Daniel R Croft, Florian Beaumatin, Alice D Baudot, Michaela Mrschtik, Mathias Rosenfeldt, Yaou Zhang, David A Gillespie, Kevin M Ryan

A novel small-molecule MRCK inhibitor blocks cancer cell invasion

新型小分子MRCK抑制剂可阻断癌细胞侵袭

Mathieu Unbekandt, Daniel R Croft, Diane Crighton, Mokdad Mezna, Duncan McArthur, Patricia McConnell, Alexander W Schüttelkopf, Simone Belshaw, Andrew Pannifer, Mairi Sime, Justin Bower, Martin Drysdale, Michael F Olson

p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival

p53 介导的转录调控和激活肌动蛋白细胞骨架调节 RhoC 至 LIMK2 信号通路促进细胞存活

Daniel R Croft, Diane Crighton, Michael S Samuel, Filipe C Lourenco, June Munro, Jenifer Wood, Karim Bensaad, Karen H Vousden, Owen J Sansom, Kevin M Ryan, Michael F Olson

The cyclin-dependent kinase PITSLRE/CDK11 is required for successful autophagy

细胞周期依赖性激酶 PITSLRE/CDK11 是成功自噬的必要条件

Simon Wilkinson, Daniel R Croft, Jim O'Prey, Arenda Meedendorp, Margaret O'Prey, Christine Dufès, Kevin M Ryan

LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells

LIM 激酶是肿瘤和肿瘤相关基质细胞产生侵袭路径所必需的

Rebecca W Scott, Steven Hooper, Diane Crighton, Ang Li, Ireen König, June Munro, Elisabeth Trivier, Grant Wickman, Pierre Morin, Daniel R Croft, John Dawson, Laura Machesky, Kurt I Anderson, Erik A Sahai, Michael F Olson

The Rho GTPase effector ROCK regulates cyclin A, cyclin D1, and p27Kip1 levels by distinct mechanisms

Rho GTPase 效应物 ROCK 通过不同的机制调节细胞周期蛋白 A、细胞周期蛋白 D1 和 p27Kip1 水平

Daniel R Croft, Michael F Olson